Young Adult Myopia: Genetic And Environmental Associations
Funder
National Health and Medical Research Council
Funding Amount
$809,271.00
Summary
Myopia affects 80% of school leavers in the cities of East Asia, 45% of Asian Australian school leavers and is probably on the rise in European Australian adolescents. Increased levels of education and lack of time outdoors are known to increase the risk of myopia. We will examine 2,000 young adults to find the genes that interact with these risk factors. In addition to confirming when these risk factors are most important, identifying molecular pathways opens the avenue of new treatments.
Exploring The Potential For Built Environment Intervention To Improve Adult And Child Physical Activity And Health
Funder
National Health and Medical Research Council
Funding Amount
$309,428.00
Summary
Health-promoting behaviours - such as physical activity - that are maintained from childhood to adulthood have a positive effect on health status. My research will examine aspects of the built environment associated with child behaviour, health and development and use these findings to formulate recommendations to key stakeholders for the design of user-friendly, active-living environments for children and interventions targeting adults.
The health effects of electronic cigarette use are virtually unknown. They have only recently been introduced into widespread use, and as such their effects on human health will not be known for many years. We will use our expertise in exposure models and health outcome measurement to provide timely hard-data on their potential to impact health – data that are urgently required to guide policy makers in this area.
Managing evolutionary-ecological process in restoring Banksia woodland resilient to global environmental changes. By manipulating genetic diversity, local selection and gene flow in restored plant communities, this project will establish suitable regimes to manage evolutionary processes in large-scale restoration, thereby improving success and resilience to future changes. It will significantly advance our understanding of evolutionary processes operating in restoration efforts, and lead to impr ....Managing evolutionary-ecological process in restoring Banksia woodland resilient to global environmental changes. By manipulating genetic diversity, local selection and gene flow in restored plant communities, this project will establish suitable regimes to manage evolutionary processes in large-scale restoration, thereby improving success and resilience to future changes. It will significantly advance our understanding of evolutionary processes operating in restoration efforts, and lead to improved restoration success, better long-term ecological functioning in restored ecosystems, better investment of resources, and maintenance of Australia’s biodiversity in the face of rapid environmental change. These findings should be of relevance to broader restoration initiatives managed by the government, community, and industry nationally and internationally.Read moreRead less
Impact of increased sediment and nutrient discharges on the long-term sustainability of the Great Barrier Reef. The Great Barrier Reef, one of Australia's greatest natural assets, is under increasing threat from extreme climatic events caused by global warming and from land-based pollution. This research will identify the main sources of sediment and nutrient pollution caused by river runoff and by how much this has increased above 'natural levels'. We will discover how the very sensitive offsho ....Impact of increased sediment and nutrient discharges on the long-term sustainability of the Great Barrier Reef. The Great Barrier Reef, one of Australia's greatest natural assets, is under increasing threat from extreme climatic events caused by global warming and from land-based pollution. This research will identify the main sources of sediment and nutrient pollution caused by river runoff and by how much this has increased above 'natural levels'. We will discover how the very sensitive offshore coral reefs have responded to increased pollution and whether this is the cause of the very devastating crown-of-thorn-starfish infestations. Understanding the long-term effects of land-based pollution on the ecology of coral reefs in the GBR will thus provide a scientific basis to help ensure that it has a sustainable future.Read moreRead less
Robotic investigation of water optical properties in the Southern Ocean. The project aims to improve our understanding of light–matter interactions in the waters of the Southern Ocean (SO), in particular the role of phytoplankton and associated material of biological origin. Phytoplankton are the energy source for the food web and a critical component of carbon cycling in the SO. However, their dynamics in the SO cannot be quantified using satellite observations because bio-optical data processi ....Robotic investigation of water optical properties in the Southern Ocean. The project aims to improve our understanding of light–matter interactions in the waters of the Southern Ocean (SO), in particular the role of phytoplankton and associated material of biological origin. Phytoplankton are the energy source for the food web and a critical component of carbon cycling in the SO. However, their dynamics in the SO cannot be quantified using satellite observations because bio-optical data processing algorithms perform poorly due to a lack of field data. This project seeks to remedy this by improving understanding of SO bio-optics, and by providing novel algorithms of known uncertainty, based on in situ data.Read moreRead less
Reconstructing changes in atmospheric circulation over the mid-latitudes of the Southern Hemisphere during the past 3000 years. The climate of the mid-latitudes of the southern hemisphere is of global significance and yet past changes have proved difficult to reconstruct due to the dearth of records. Working across the Southern Ocean region using tree rings, lake sediments and ice cores, the project will produce the first comprehensive reconstruction spanning the last 3000 years.
ARC Centre of Excellence for Integrated Coral Reef Studies. The overarching aim of the ARC Centre of Excellence for Integrated Coral Reef Studies is to provide the scientific knowledge necessary for sustaining ecosystem goods and services of the worlds coral reefs, which support the livelihoods and food security of millions of people in the tropics. The Centre will enhance Australia's global leadership in coral reef science through three ambitious research programs addressing the future of coral ....ARC Centre of Excellence for Integrated Coral Reef Studies. The overarching aim of the ARC Centre of Excellence for Integrated Coral Reef Studies is to provide the scientific knowledge necessary for sustaining ecosystem goods and services of the worlds coral reefs, which support the livelihoods and food security of millions of people in the tropics. The Centre will enhance Australia's global leadership in coral reef science through three ambitious research programs addressing the future of coral reefs and their ability to adapt to change. A key outcome of the research will be providing tangible benefits to all Australians by building bridges between the natural and social sciences, strengthening capacity, and informing and supporting transformative changes in coral reef governance and management.Read moreRead less
Assessing the ecosystem-wide risks of threatened species translocation. Assessing the ecosystem-wide risks of threatened species translocation. This project aims to develop the first quantitative risk assessment framework to improve decisions about moving threatened species to new places. Moving threatened plants and animals to new environments, or reintroducing them where they previously persisted, is a growing focus of conservation. Moving species can have unanticipated effects on other specie ....Assessing the ecosystem-wide risks of threatened species translocation. Assessing the ecosystem-wide risks of threatened species translocation. This project aims to develop the first quantitative risk assessment framework to improve decisions about moving threatened species to new places. Moving threatened plants and animals to new environments, or reintroducing them where they previously persisted, is a growing focus of conservation. Moving species can have unanticipated effects on other species in the ecosystem. Although the International Union for Conservation of Nature deems ecosystem-wide risk assessments essential for conservation translocations, no framework exists to assess these risks and inform these decisions. New tools for assessing the risks of conservation translocations are expected to improve global and local conservation outcomes.Read moreRead less
Characterisation Of Eurl, A Novel Gene Implicated In The Etiology Of Abnormal Brain Development And Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$597,541.00
Summary
Intellectual disability affects around one per cent of Australians, and can arise from genetic abnormalities during fetal life, such as through abnormal regulation of gene expression. We have identified a novel gene, known as eurl, which controls brain assembly as well as the ability of neurons to form functional connections within the brain. We will investigate how this novel gene controls brain development, and characterise eurl as a potential therapeutic target for learning and memory.