Assessing Infrastructure And Contextual Factors In Relation To Cardiometabolic Outcomes In Remote Indigenous Communities: Evidence For Policy Change
Funder
National Health and Medical Research Council
Funding Amount
$1,113,005.00
Summary
Cardiometabolic diseases account for the major burden of morbidity and mortality for Indigenous populations. This study with 75 remote Indigenous communities will be the first to evaluate features of their social, built and physical environments in relation to cardiometabolic risks and diseases. Policy-relevant results will identify features of environments to be targeted to reduce chronic diseases for Indigenous peoples in remote communities.
Identification Of Genes For X-linked Mental Retardation.
Funder
National Health and Medical Research Council
Funding Amount
$675,228.00
Summary
We propose to identify novel heritable causes of intellectual disability using 22 large and well-characterised families from Australia. In these families we have refined the location of the genetic defect to the chromosome X and excluded the contribution of all so far known genes. We will achieve this using the technology of massive parallel sequencing. At the completion of the project we will have identified novel causes of intellectual disability and devised tests to identify them.
Testing The Behavioural And Psychosocial Mechanisms Underlying Geographic Variation In Metabolic Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$415,457.00
Summary
This study seeks to assess the mechanisms that explain the link between residential area features and the metabolic syndrome (obesity and high blood pressure, lipids and glucose), related to cardiometabolic diseases. There is more metabolic syndrome in disadvantaged areas but the reasons for this have not been empirically established. We will evaluate behavioural and psychosocialmechanisms that might independently and jointly explain the association between place and metabolic syndrome.
The effect of aerial spraying of two pesticides on semi-arid grasslands. The project will investigate how two pesticides, fipronil and metarrhizium, used to control locusts, affect semi-arid ecosystems by examining impacts on invertebrates, their predators, lizards and soil processes. The effects will be followed through time in a large scale experiment to determine recovery and compare each pesticide.
Keystone microbes and planktonic guilds in Australia's oceans. This project aims to unveil the ocean’s hidden sentinels, “keystone microbes” that underpin precious ecosystem services, and which can be used to monitor and model changes in ocean function. Marine microbes account for 90 per cent of oceanic biomass and every litre of seawater contains ~20,000 different species, but it is not known which species control ocean health and productivity. This project intends to provide definitive evidenc ....Keystone microbes and planktonic guilds in Australia's oceans. This project aims to unveil the ocean’s hidden sentinels, “keystone microbes” that underpin precious ecosystem services, and which can be used to monitor and model changes in ocean function. Marine microbes account for 90 per cent of oceanic biomass and every litre of seawater contains ~20,000 different species, but it is not known which species control ocean health and productivity. This project intends to provide definitive evidence of these keystones’ cellular level biogeochemical and metabolic capacity. Ultimately, this knowledge is expected to predict the resilience of ocean ecosystems and their response to change. The capacity to predict their dynamics will help provide investment clarity and increase healthy outcomes from activities involving human-ocean interactions such as recreation, food production and tourism.Read moreRead less
The Role Of Respiratory And Upper Airway Neural Control In Sleep Disordered Breathing
Funder
National Health and Medical Research Council
Funding Amount
$346,018.00
Summary
Obstructive Sleep Apnea (OSA) is a disorder associated with snoring. It affects 4% of adult men and causes excessive daytime sleepiness leading to increased accidents, high blood pressure and premature cardiovascular disease eg. heart attacks and strokes. Patients with OSA obstruct the floppy portion of the upper airway (UA) during sleep and consequently experience frequent episodes of oxygen deprivation as well as sleep fragmentation. OSA is at least 2-3 times more common in men than women. Whi ....Obstructive Sleep Apnea (OSA) is a disorder associated with snoring. It affects 4% of adult men and causes excessive daytime sleepiness leading to increased accidents, high blood pressure and premature cardiovascular disease eg. heart attacks and strokes. Patients with OSA obstruct the floppy portion of the upper airway (UA) during sleep and consequently experience frequent episodes of oxygen deprivation as well as sleep fragmentation. OSA is at least 2-3 times more common in men than women. While OSA patients seem, on average, to have smaller upper airways than normal subjects, the cause of OSA cannot be attributed to this factor alone. For example, a small UA cannot explain the male tendency for OSA. Abnormalities in breathing control or the control of upper airway muscles that normally hold the airway open might also be important in OSA. Men have previously been shown to have a greater increase in UA resistance during sleep than women, consistent with the idea that a gender difference in UA muscle control partly explains why more men than women have OSA. We aim to investigate how changes in breathing and UA dilator muscle control might lead to unstable patterns of breathing and to OSA. We propose that protective UA muscle reflexes are reduced during sleep more in men than women, and are reduced by low blood oxygen levels and alcohol (a known aggravator of sleep apnea). We further propose that low blood oxygen levels not only result from OSA but may also aggravate OSA by preferentially reducing the activity of UA dilating muscles, by making breathing patterns overall less stable and by depressing the ability of subjects to arouse from sleep to an airway blockage. We believe that this tendency to decrease UA activity may be exaggerated in OSA patients. We also propose that men are more vulnerable to the deleterious effects of low oxygen than women. We will also examine if men and snorers have exaggerated breathing responses on arousal from sleep.Read moreRead less
Past trends and future risk of climate extremes in southern Australia. Prolonged droughts and periods of heightened flood and fire risk present a major challenge for Australia’s society and economy. This proposal aims to better resolve the causes and risks of decadal climate extremes through a suite of high quality records of temperature, rainfall/evaporation and humidity in southern Australia over 2000 years. Novel geochemical analyses will be developed and applied to lake sediments – method de ....Past trends and future risk of climate extremes in southern Australia. Prolonged droughts and periods of heightened flood and fire risk present a major challenge for Australia’s society and economy. This proposal aims to better resolve the causes and risks of decadal climate extremes through a suite of high quality records of temperature, rainfall/evaporation and humidity in southern Australia over 2000 years. Novel geochemical analyses will be developed and applied to lake sediments – method development which is likely to benefit climate, minerals and biosecurity research. New knowledge of mechanisms underlying climate variability is expected to benefit fundamental research, while future-facing models will allow land managers and policy makers to better anticipate extraordinary climate events.Read moreRead less
Unravelling how aquatic coastal networks regulate nitrogen removal . The aim of this project is to determine the nitrogen removal pathways of the coastal zone using a number of innovative field and modelling approaches. Little is known about how the complex coastal landscape controls trade-offs that maximise nitrogen removal but minimise nitrous oxide (a potent greenhouse gas) emissions. The outcomes of this study will significantly advance our understanding of the coastal zone in regional and g ....Unravelling how aquatic coastal networks regulate nitrogen removal . The aim of this project is to determine the nitrogen removal pathways of the coastal zone using a number of innovative field and modelling approaches. Little is known about how the complex coastal landscape controls trade-offs that maximise nitrogen removal but minimise nitrous oxide (a potent greenhouse gas) emissions. The outcomes of this study will significantly advance our understanding of the coastal zone in regional and global nitrogen budgets. This will provide significant benefits such as a new science-based quantitative framework to facilitate best practice management to reduce terrestrial nitrogen loads and associated downstream impacts such as eutrophication, and reduce nitrous oxide emissions and associated global warming.
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Discovery Early Career Researcher Award - Grant ID: DE180101518
Funder
Australian Research Council
Funding Amount
$364,200.00
Summary
Aquifers as climate logs: untangling replenishment mechanisms. This project aims to develop methods that use environmental tracers to provide detailed information about groundwater ages and relate the age structure of groundwater systems to past climatic conditions. The impacts of climate change on groundwater resources is an important question in hydrogeological studies. The age of groundwater within an aquifer represents a detailed log of past recharge events. The project will generate methods ....Aquifers as climate logs: untangling replenishment mechanisms. This project aims to develop methods that use environmental tracers to provide detailed information about groundwater ages and relate the age structure of groundwater systems to past climatic conditions. The impacts of climate change on groundwater resources is an important question in hydrogeological studies. The age of groundwater within an aquifer represents a detailed log of past recharge events. The project will generate methods for assessing the past history of groundwater resources, and provide insight into the viability of groundwater in the future. This will improve understanding of how groundwater resources will behave under a changing climate.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100035
Funder
Australian Research Council
Funding Amount
$1,205,137.00
Summary
Founding an Australian Critical Zone Observatory Network. This proposal founds a new network of Australian Critical Zone Observatories. The network will fill essential knowledge gaps about interactions of under- and above-ground environmental processes and their responses to disturbance and change. These interactions determine the sustainability of food, clean water, mineral resources and Australian ecosystems, and cannot be studied with existing environmental infrastructure. The 5 foundation ....Founding an Australian Critical Zone Observatory Network. This proposal founds a new network of Australian Critical Zone Observatories. The network will fill essential knowledge gaps about interactions of under- and above-ground environmental processes and their responses to disturbance and change. These interactions determine the sustainability of food, clean water, mineral resources and Australian ecosystems, and cannot be studied with existing environmental infrastructure. The 5 foundational sites will host integrated monitoring equipment to observe stocks and fluxes of carbon, water, energy and mass across the “Critical Zone” – the vertical span from plant canopies to fresh bedrock. Joining a burgeoning international movement, the network will catalyse Critical Zone science in Australia.Read moreRead less