Studies On The Expression Of Muscarinic Receptors: Implications For The Pathology Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$498,791.00
Summary
Schizophrenia is a severe psychiatric disorder that affects approximately 1% of the population. This project will help define changes in the molecules in the brain of subjects with schizophrenia which are likely to be involved in two symptoms of the disorder, the psychoses and cognitive deficits. Understanding the cause of the cognitive deficits of schizophrenia is a high priority because they are the most disabilitating symptom of the disorder and do not respond to current drug treatments.
Assessing Infrastructure And Contextual Factors In Relation To Cardiometabolic Outcomes In Remote Indigenous Communities: Evidence For Policy Change
Funder
National Health and Medical Research Council
Funding Amount
$1,113,005.00
Summary
Cardiometabolic diseases account for the major burden of morbidity and mortality for Indigenous populations. This study with 75 remote Indigenous communities will be the first to evaluate features of their social, built and physical environments in relation to cardiometabolic risks and diseases. Policy-relevant results will identify features of environments to be targeted to reduce chronic diseases for Indigenous peoples in remote communities.
Epigenetic Programming Of Immune Development In Utero: Role Of The Maternal Environment In The Allergy Epidemic
Funder
National Health and Medical Research Council
Funding Amount
$764,463.00
Summary
This study will provide new insights into the development of allergic disease. Specifically, we will explore the hypothesis that allergic disease and other disorders or immune dysregulation occur as a result of gene-environmental interactions in early life, and that these events begin in pregnancy when the developing fetus is still developing and most susceptible to these effects.
Discovery Indigenous Researchers Development - Grant ID: DI100100130
Funder
Australian Research Council
Funding Amount
$180,834.00
Summary
Developing predictive tools for rapid assessment of multiple impacts, including climate change, on the marine ecosystem of Torres Strait (Australia). This project will underpin Australia's long-term commitment to maintain environmental biodiversity and sustainability in the face of synergistic effects from multiple threats. We will describe the consequences of threats and stressors on marine processes, harvested resources, and ecosystem functioning by identifying vulnerable species and habitats. ....Developing predictive tools for rapid assessment of multiple impacts, including climate change, on the marine ecosystem of Torres Strait (Australia). This project will underpin Australia's long-term commitment to maintain environmental biodiversity and sustainability in the face of synergistic effects from multiple threats. We will describe the consequences of threats and stressors on marine processes, harvested resources, and ecosystem functioning by identifying vulnerable species and habitats. We will provide management advice on balancing cultural and ecosystem integrity, economic efficiency, and ecosystem resilience under scenarios of climate and environmental change. This information is of immediate use by Australian government agencies. The project will put Australian scientists at the forefront of research focused on the adaptation of marine ecosystems to synergistic effects.Read moreRead less
Health And Fertility Of Young Men Conceived Using Intra-cytoplasmic Sperm Injection
Funder
National Health and Medical Research Council
Funding Amount
$362,570.00
Summary
The injection of a single sperm into the egg (ICSI) has been the main IVF treatment for men with poor sperm quality since 1993 but is now often used for other types of infertility. Concern has been raised about the health of the children. We will approach >800 parents and their adult sons conceived using ICSI and will assess his general health and development, and fertility. This work will improve patient counselling and practice guidelines, and direct research into the safety of ICSI.
When Sinks Become Sources;
Understanding Persistent Organic Pollutant Behaviour in Dynamic Polar Environments. Polar regions are environmental ‘sinks’ for man-made, Persistent Organic Pollutants (POPs). The unique biogeochemical processes governing POP behaviour in the Polar landscape are not understood, yet are necessary to predict their impact in polar ecosystems. The Antarctic seasonal-ice zone provides an archetype for multi-compartment, temporal observations of POP partitioning in respons ....When Sinks Become Sources;
Understanding Persistent Organic Pollutant Behaviour in Dynamic Polar Environments. Polar regions are environmental ‘sinks’ for man-made, Persistent Organic Pollutants (POPs). The unique biogeochemical processes governing POP behaviour in the Polar landscape are not understood, yet are necessary to predict their impact in polar ecosystems. The Antarctic seasonal-ice zone provides an archetype for multi-compartment, temporal observations of POP partitioning in response to the major drivers of ice cover and primary productivity. In addition, the major Antarctic POP reservoirs of seawater and ice will be characterised. Empirical data will be used to parameterise a regional fugacity model. Model application to varying climate scenarios will extend our understanding of POP behaviour and threat in polar regions.Read moreRead less
Fauna, fuel and fire: effects of animals on bushfire risk. This project aims to determine the extent that animals influence fire regimes through effects on fuel load and characteristics. Minimising the risk of large, severe bushfires, while conserving native species is one of the greatest challenges facing managers of fire-prone ecosystems globally. Using a powerful combination of landscape-scale field observations, experimental manipulations of animal densities, and modelling, the project expec ....Fauna, fuel and fire: effects of animals on bushfire risk. This project aims to determine the extent that animals influence fire regimes through effects on fuel load and characteristics. Minimising the risk of large, severe bushfires, while conserving native species is one of the greatest challenges facing managers of fire-prone ecosystems globally. Using a powerful combination of landscape-scale field observations, experimental manipulations of animal densities, and modelling, the project expects to quantify interactions between animals, bushfire fuel and fire regimes in south eastern Australian forests, woodlands and scrublands. This evidence should benefit the design of integrated, efficient, and complementary strategies for fire and fauna management in Australia’s extensive fire-prone ecosystems.Read moreRead less
Mega spatial-scale, multi time-scale, ensemble assessment of climate change driven coastal change in South Eastern Australia. Climate change driven variations in mean sea level, storm surges, and waves will change the world's coastline. This project will, for the first time, develop innovative modelling methods to quantify the integrated impact of these climate drivers on coastal erosion along Australia's most developed and populated coastline: Sydney to Brisbane.
Impact of increased sediment and nutrient discharges on the long-term sustainability of the Great Barrier Reef. The Great Barrier Reef, one of Australia's greatest natural assets, is under increasing threat from extreme climatic events caused by global warming and from land-based pollution. This research will identify the main sources of sediment and nutrient pollution caused by river runoff and by how much this has increased above 'natural levels'. We will discover how the very sensitive offsho ....Impact of increased sediment and nutrient discharges on the long-term sustainability of the Great Barrier Reef. The Great Barrier Reef, one of Australia's greatest natural assets, is under increasing threat from extreme climatic events caused by global warming and from land-based pollution. This research will identify the main sources of sediment and nutrient pollution caused by river runoff and by how much this has increased above 'natural levels'. We will discover how the very sensitive offshore coral reefs have responded to increased pollution and whether this is the cause of the very devastating crown-of-thorn-starfish infestations. Understanding the long-term effects of land-based pollution on the ecology of coral reefs in the GBR will thus provide a scientific basis to help ensure that it has a sustainable future.Read moreRead less
Keystone microbes and planktonic guilds in Australia's oceans. This project aims to unveil the ocean’s hidden sentinels, “keystone microbes” that underpin precious ecosystem services, and which can be used to monitor and model changes in ocean function. Marine microbes account for 90 per cent of oceanic biomass and every litre of seawater contains ~20,000 different species, but it is not known which species control ocean health and productivity. This project intends to provide definitive evidenc ....Keystone microbes and planktonic guilds in Australia's oceans. This project aims to unveil the ocean’s hidden sentinels, “keystone microbes” that underpin precious ecosystem services, and which can be used to monitor and model changes in ocean function. Marine microbes account for 90 per cent of oceanic biomass and every litre of seawater contains ~20,000 different species, but it is not known which species control ocean health and productivity. This project intends to provide definitive evidence of these keystones’ cellular level biogeochemical and metabolic capacity. Ultimately, this knowledge is expected to predict the resilience of ocean ecosystems and their response to change. The capacity to predict their dynamics will help provide investment clarity and increase healthy outcomes from activities involving human-ocean interactions such as recreation, food production and tourism.Read moreRead less