Hydrological changes in Australia and the South Pacific. This project plans to use stalagmites from the South–West Pacific to generate continuous rainfall records for the last 2000 years. Stalagmites contain uncorrupted data that are not available in other archives, and provide unparalleled accurate chronologies. The spatial and temporal variations of the data may highlight the interplay of climate drivers, such as El Niño Southern Oscillation, and how they change the distribution of rainfall in ....Hydrological changes in Australia and the South Pacific. This project plans to use stalagmites from the South–West Pacific to generate continuous rainfall records for the last 2000 years. Stalagmites contain uncorrupted data that are not available in other archives, and provide unparalleled accurate chronologies. The spatial and temporal variations of the data may highlight the interplay of climate drivers, such as El Niño Southern Oscillation, and how they change the distribution of rainfall in the Pacific. This knowledge would increase our scientific understanding and enable better predictions of the recurrence of droughts and wet events in Australia.Read moreRead less
In 2013 there were ~200 million clinical cases of malaria, causing ~600,000 deaths. All antimalarial drugs are now associated with malaria parasite resistance. Thus, new therapies are urgently needed, including new drugs to prevent this disease. We have made the exciting discovery that an existing antimalarial drug can kill malaria parasites in a unique, previously unknown, manner. Here, we will investigate how this occurs and develop new drug candidates for malaria prevention.
Reconstructing changes in atmospheric circulation over the mid-latitudes of the Southern Hemisphere during the past 3000 years. The climate of the mid-latitudes of the southern hemisphere is of global significance and yet past changes have proved difficult to reconstruct due to the dearth of records. Working across the Southern Ocean region using tree rings, lake sediments and ice cores, the project will produce the first comprehensive reconstruction spanning the last 3000 years.
Development of a heatwave definition using the health risk-based metrics. Climate change is increasingly recognised as this century's biggest global health threat, but the health consequences of climate change remain to be quantified. A typical example is health risks from heatwaves which kill more people than any other natural hazard in Australia, but few comprehensive datasets are available on what affects heatwaves can have on population health and well-being, and how such evidence can be tra ....Development of a heatwave definition using the health risk-based metrics. Climate change is increasingly recognised as this century's biggest global health threat, but the health consequences of climate change remain to be quantified. A typical example is health risks from heatwaves which kill more people than any other natural hazard in Australia, but few comprehensive datasets are available on what affects heatwaves can have on population health and well-being, and how such evidence can be translated into policy. This project aims to understand the health risks associated with heatwaves, to develop health risk-based metrics to define a heatwave across different areas, and to evaluate its implications for the development of social and health policies within an Australian context.Read moreRead less
Stress-induced Genomic Instability As A Driver Of Adaptive Responses In Human Cancer Cells
Funder
National Health and Medical Research Council
Funding Amount
$690,426.00
Summary
Growing experimental evidence suggests human cancer cells use evolutionary conserved programs to regulate their mutation rates in response to pharmacological agents, accelerating adaptation and the emergence of resistance. The purpose of our study is to identify the common molecular pathways and genetic mechanisms driving the regulation of mutation rates. Targeting of these pathways using a new generation of “anti-evolution” drugs is an attractive possibility for novel therapeutic approaches.
Unravelling The Mechanism Of MHC Class-I Associated Drug Hypersensitivities
Funder
National Health and Medical Research Council
Funding Amount
$566,308.00
Summary
Some drugs cause adverse reactions that are life threatening. We think these reactions are mediated by killer T cells as they are genetically controlled by immune response genes that normally guide immunity to microbes. We will study immune reactions to the drug abacavir, used to treat HIV (AIDS); allopurinol used to prevent gout and carbamazepine, used to treat epilepsy. The study may also help devise better treatments for patients who experience severe forms of these reactions.
Discovery Early Career Researcher Award - Grant ID: DE130100668
Funder
Australian Research Council
Funding Amount
$351,805.00
Summary
The further back we look, the further forward we can see: 1,000 years of past climate to help predict future climate change in Australia. Reconstructing 1,000 years of Australia's past climate will greatly extend our understanding of natural climate variability currently estimated from weather observations. For the first time, Australian climate variations over the last millennium will be used to assess the accuracy of climate model simulations for our region.
Hydrologic modelling for a changing world. Realistic modelling of streamflow under climate change requires development of new hydrologic modelling techniques that are robust under changing conditions. This project will develop and test those new techniques and apply them to the latest climate change projections to assess the likely climate change impact on Australia’s water resources.
Reconstructing millennial-scale streamflow variability to assess near-future risks to water-generated renewable energy. Hydroelectric power is a key component of Australia's national renewable energy policy. The project will combine Hydro Tasmania's water supply and distribution network with historical reconstructions of streamflow variability to conduct stress tests of future water supplies and hydroelectric generating capacity for the Australian power grid.
Unlocking the environmental archives of the Kimberley’s past. This project aims to reconstruct the environmental history of Australia’s Kimberley region spanning the past 60,000 years. Through a multidisciplinary approach, the project will provide new understanding of the causes of environmental change and impacts on this region since the arrival of Australia’s earliest inhabitants. This will inform the development of conservation policy to ensure preservation of the region's globally significan ....Unlocking the environmental archives of the Kimberley’s past. This project aims to reconstruct the environmental history of Australia’s Kimberley region spanning the past 60,000 years. Through a multidisciplinary approach, the project will provide new understanding of the causes of environmental change and impacts on this region since the arrival of Australia’s earliest inhabitants. This will inform the development of conservation policy to ensure preservation of the region's globally significant rock art against environmental change and economic development.
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