Development Of BRET Detection Systems: Tools For Functional Proteomics And Drug Discovery
Funder
National Health and Medical Research Council
Funding Amount
$376,320.00
Summary
The internal structure of articular cartilage is critical to its biomechanical function. Cartilage is one of the most intricate and difficult tissues to examine in-vivo. Maintenance of its functional characteristics depends heavily of the internal microstructure of the tissue, while conventional arthroscopy can only give a view of the surface and provides no information on the internal structure. Biopsy examination can also destroy the integrity of the tissue, making it impossible to concurrentl ....The internal structure of articular cartilage is critical to its biomechanical function. Cartilage is one of the most intricate and difficult tissues to examine in-vivo. Maintenance of its functional characteristics depends heavily of the internal microstructure of the tissue, while conventional arthroscopy can only give a view of the surface and provides no information on the internal structure. Biopsy examination can also destroy the integrity of the tissue, making it impossible to concurrently examine the structure and function of the tissue. The structure-function relationship is thus critical to the study and the advancement of clinical treatment techniques for cartilage disorders. Osteoarthritis is characterized by severe disruption to the cartilage matrix. The emergence of autologous chondrocyte implant (ACI) therapy as a method for repairing cartilage defects has further increased interest in clinical techniques for the examination of cartilage structure and function. The development of confocal microscopy facilitates internal examination of loaded tissue for the first time, enabling direct examination of the association between structure and function of the tissue. A prototype confocal arthroscope has been developed to facilitate clinical examination of cartilage structure. This, in turn, allows the functional characteristics of the tissue to be deduced. Cartilage exhibits little intrinsic repair making biopsies undesirable. Thus, with respect to cartilage in particular, the developed technologies promise to enable examination to a level of detail which was previously impossible. The current prototype arthroscope has demonstrated the feasibility of a genuine clinical instrument. This grant application seeks funds to conduct initial clinical trials in order to gain sufficient practical feedback to enable design and construction of a clinically ready system.Read moreRead less
On the mechanism of boiling instability in microchannels. This project will enable designers to create highly efficient miniaturised devices based on the boiling of fluids such as water or organics. These devices include micro-power generation systems, coolers for computer chips and solar collectors, and micro-chemical process systems. Such devices provide environmental, safety and economic benefits.
High Energy Density - High Delivery Rate Thermal Energy Storage. This project aims to address the intermittency of renewable energy sources using novel thermal storage media. Advanced heat transfer modelling and in situ neutron diffraction and imaging are intended to be used to optimise the microstructure of newly developed miscibility gap thermal storage systems. The new media store energy as the latent heat of fusion of one phase in a stable, high thermal conductivity inverted microstructure. ....High Energy Density - High Delivery Rate Thermal Energy Storage. This project aims to address the intermittency of renewable energy sources using novel thermal storage media. Advanced heat transfer modelling and in situ neutron diffraction and imaging are intended to be used to optimise the microstructure of newly developed miscibility gap thermal storage systems. The new media store energy as the latent heat of fusion of one phase in a stable, high thermal conductivity inverted microstructure. The high energy density of the latent heat (0.5-4.5 Mega Joules/Litre) requires storage volumes as little as five per cent of those relying upon heat capacity and the metal matrix has a hundred-fold greater thermal conductivity than current systems. It is proposed that a range of such materials will be engineered for concentrated solar thermal and space heating applications.Read moreRead less
Dehumidification and cooling driven by solar/waste heat using liquid desiccants. The provision of comfort cooling is responsible for a considerable and increasing portion of the world energy demand and electricity peak demand. To substitute electrically driven vapour compression machines with their high electrical energy consumption and especially high peak loads, the use of solar energy or waste heat for a cooling and dehumidification system driven by liquid desiccants is a promising opportunit ....Dehumidification and cooling driven by solar/waste heat using liquid desiccants. The provision of comfort cooling is responsible for a considerable and increasing portion of the world energy demand and electricity peak demand. To substitute electrically driven vapour compression machines with their high electrical energy consumption and especially high peak loads, the use of solar energy or waste heat for a cooling and dehumidification system driven by liquid desiccants is a promising opportunity. The project utilises the complementary strengths in the research groups to develop practical and economically feasible cooling/dehumidification systems for different types of buildings with different moisture removal and cooling requirements at different locations (Australia, Southern Europe).Read moreRead less
Design of high performance heat sink composites. Heat sink composites are advanced materials that have the very substantial but widely untapped potential to reduce Society's energy consumption by means of utilizing waste energy or through energy-efficient temperature control. This Project uses computational analysis and parallel experimentation to design optimum heat-sink composites for highly energy-efficient temperature control of chemical batteries or electronic components as well as the mean ....Design of high performance heat sink composites. Heat sink composites are advanced materials that have the very substantial but widely untapped potential to reduce Society's energy consumption by means of utilizing waste energy or through energy-efficient temperature control. This Project uses computational analysis and parallel experimentation to design optimum heat-sink composites for highly energy-efficient temperature control of chemical batteries or electronic components as well as the means for the efficient heating/cooling of buildings. The outcomes of the project will lay the scientific foundation for the industrial scale development of advanced heat sinks that will lower energy costs and decrease climate changing emissions. This represents a new market for Australian industry.Read moreRead less
Thermal transport in multi-phase flows for concentrating solar applications. This project seeks to advance the field of heat transfer in high-temperature systems involving liquid metals, with emphasis on energy storage and solar power technologies. The concept couples a tubular sodium boiler with a sodium chloride phase-change storage system for continuous energy supply. Sodium chloride is low cost and has a melting temperature suitable for a wide range of industrial processes. The project plans ....Thermal transport in multi-phase flows for concentrating solar applications. This project seeks to advance the field of heat transfer in high-temperature systems involving liquid metals, with emphasis on energy storage and solar power technologies. The concept couples a tubular sodium boiler with a sodium chloride phase-change storage system for continuous energy supply. Sodium chloride is low cost and has a melting temperature suitable for a wide range of industrial processes. The project plans to address the challenge of sodium stability in highly irradiated tubes by investigating mass, momentum, energy and radiative transport in liquid metals. It is intended that this will inform the design and testing of novel sodium boilers to provide stable and isothermal process heat for continuous or on-demand production of power, chemical fuels and commodities.Read moreRead less
A Fundamental Study on Redox Behaviour of Oxygen Carriers in Chemical Looping Combustion. Our goal here is to acquire fundamental knowledge about the redox behaviour of metal oxide oxygen carriers which, arguably, underpins the feasibility of the Chemical Looping Combustion (CLC) concept. Although the proposed work is fundamental and will contribute to the advancement of knowledge, the results will have immediate practical applications in power generation industry at both national and internatio ....A Fundamental Study on Redox Behaviour of Oxygen Carriers in Chemical Looping Combustion. Our goal here is to acquire fundamental knowledge about the redox behaviour of metal oxide oxygen carriers which, arguably, underpins the feasibility of the Chemical Looping Combustion (CLC) concept. Although the proposed work is fundamental and will contribute to the advancement of knowledge, the results will have immediate practical applications in power generation industry at both national and international levels. This should significantly contribute to the Australian Government's efforts in producing world class solutions for abatement of greenhouse emissions (Research Priority 1: An Environmentally Sustainable Australia, Priority Goal 1.4 - Reducing and capturing emissions in transport and energy generation).Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100131
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Multifunctional micro/nano-engineered solar thermal receivers. This project is designed to develop a new class of thermal receivers that overcome key challenges in today's concentrating solar thermal systems. The development of accurate micro/nanofabrication and characterisation techniques in recent years has made it possible to achieve thermofluid devices that are engineered from the bottom up to achieve high performance at relatively low cost. This project aims to develop a new class of solar ....Multifunctional micro/nano-engineered solar thermal receivers. This project is designed to develop a new class of thermal receivers that overcome key challenges in today's concentrating solar thermal systems. The development of accurate micro/nanofabrication and characterisation techniques in recent years has made it possible to achieve thermofluid devices that are engineered from the bottom up to achieve high performance at relatively low cost. This project aims to develop a new class of solar thermal receivers which use micro/nanotechnology to directly absorb concentrated solar energy with very little pumping power and minimal radiative heat loss. By tailoring the geometry and materials inside the receiver, the project expects to achieve a unique level of integrated optical, heat transfer and fluid flow control.Read moreRead less