Cardiac Dysfunction In Diabetes: A Novel Therapeutic Approach
Funder
National Health and Medical Research Council
Summary
Diabetes is a global epidemic with high mortality associated with heart failure. I propose a new hypothesis: diabetic heart failure reflects a progressive decline in heart pump efficiency due to an accumulation of large glycogen stores in heart muscle cells. This research aims to characterise the underlying causes of heart failure in diabetes and identify intervention potential to rescue function and prevent the progression into failure.
Type 2 diabetes is the most common endocrine disease in the world and up to 60% of diabetic patients have heart disease. Heart disease is the most expensive heath condition and biggest cause of death in Australia. Diabetic patients often accumulate fat (triglyceride) within their heart cells, leading to diabetic heart disease. The present study sought to determine if diabetic patients with increased fat within their heart cells have more scarring which eventually results heart muscle dysfunction ....Type 2 diabetes is the most common endocrine disease in the world and up to 60% of diabetic patients have heart disease. Heart disease is the most expensive heath condition and biggest cause of death in Australia. Diabetic patients often accumulate fat (triglyceride) within their heart cells, leading to diabetic heart disease. The present study sought to determine if diabetic patients with increased fat within their heart cells have more scarring which eventually results heart muscle dysfunction.Read moreRead less