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Role Of TNF-á In Growth, Lineage Commitment And Differentiation Of Liver Progenitor Cells
Funder
National Health and Medical Research Council
Funding Amount
$228,589.00
Summary
The infection rate of HBV is 20% in Chinese and 10% in Australian in particularly aboriginal. The end-point of this disease is development liver failure and need functional replacement of the liver. Cell therapy represents an alternative of liver transplantation owing to shortage of organ. The information derived from this study is essential for developing strategies to promote growth and differentiation of liver progenitor cell both in vivo and in vitro for therapies to treat liver diseases.
B Cell Activation Generates Antibodies To Promote Vascular And Renal Inflammation, Remodelling And Dysfunction In Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$327,193.00
Summary
Hypertension is a major contributor to chronic cardiovascular and renal diseases, with recent literature suggesting the pathogenesis is similar to that of autoimmune diseases. This fellowship will enhance the current understanding of the pathogenesis of hypertension and the associated inflammation of the kidneys and vasculature. It will also assess the therapeutic potential of drugs that dampen the immune response in several animal models of hypertension.
Blood clotting in the wrong place at the wrong time is responsible for up to 50% of the morbidity and mortality of the population through diseases such as heart attack, stroke, venous thrombosis. It also contributes to cancer progression and cancer related death. Blood clotting is initiated when a protein on the cell surface known as tissue factor becomes active. We will determine how activation of tissue factor participates in the blood clotting process. This will help in disease prevention.