In Search Of Airways Collapse - A Multimodal Device For The Diagnosis Of Obstructive Sleep Apnoea
Funder
National Health and Medical Research Council
Funding Amount
$479,786.00
Summary
Using a combination of off-the-shelf and emerging technologies we will develop a multimodal diagnostic device that will identify and characterize the points of airway collapse that occur in patients with obstructive sleep apnoea. Using this multimodal approach will allow sleep clinicians to recommend the best form of therapeutic intervention for each individual patient rather than the current strong reliance on positive pressure facemasks.
Endoscopic Removal Of Lesions In The Gastrointestinal Tract
Funder
National Health and Medical Research Council
Funding Amount
$71,855.00
Summary
Barrett's oesophagus and flat colonic polyps are premalignant lesions with potential for progression to oesophageal and colorectal cancer, respectively. These cancers make up a signifiant portion of the burden of cancer disease in Australia. This research aims to improve outcomes of patients with Barrett's oesophagus and flat polyps by establishing the most appropriate treatment approach to Barrett's oesophagus, identifying risk factors that cause disease progression and by novel ways of enhanci ....Barrett's oesophagus and flat colonic polyps are premalignant lesions with potential for progression to oesophageal and colorectal cancer, respectively. These cancers make up a signifiant portion of the burden of cancer disease in Australia. This research aims to improve outcomes of patients with Barrett's oesophagus and flat polyps by establishing the most appropriate treatment approach to Barrett's oesophagus, identifying risk factors that cause disease progression and by novel ways of enhancing the technique of removal of polyps.Read moreRead less
REMEDYING THE NEGLECT OF THE MOST COMMON COMPLICATION OF INFLAMMATORY BOWEL DISEASE: INTESTINAL STRICTURES.
Funder
National Health and Medical Research Council
Funding Amount
$123,368.00
Summary
Inflammatory bowel disease is a significant cause of debility in the Australian community. Some patients develop narrowing of the bowel which can cause intestinal blockages and require surgery. My research in this area will identify predictors of severe disease, allowing doctors to individualise treatment plans for each patient. I will also work to determine the best model of medical treatment and investigate new techniques which have the potential to avoid surgery.
Stricture Definition And Treatment (STRIDENT) Studies: New Diagnostic And Treatment Modalities For Inflammatory Bowel Disease Strictures
Funder
National Health and Medical Research Council
Funding Amount
$124,676.00
Summary
Inflammatory bowel disease (IBD), which includes Crohn disease and Ulcerative colitis, is becoming increasingly common in Australia. IBD strictures, which are a narrowing of bowel wall as a result of inflammation, can cause obstruction or blockage of food and liquid contents in the bowel. This results in significant patient morbidity and disease burden. Our research will aim to characterise strictures in IBD and investigate novel medical treatments to significantly improve outcomes in IBD.
Proteomics And Confocal Endomicroscopy In The Evaluation Of Inflammatory Bowel Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$436,096.00
Summary
Inflammatory bowel diseases (IBD) result in devastating consequences and affect more young Australians than epilepsy or road traffic accidents. Damaged bowel results in loss of the normal gut barrier and flora can enter the tissue and even the blood. This concept of the "leaky gut" has been previously difficult to demonstrate. This can now be seen and measured using two new technologies called proteomics and confocal endomicroscopy. These tests offer new avenues of research for the 61,000 Austra ....Inflammatory bowel diseases (IBD) result in devastating consequences and affect more young Australians than epilepsy or road traffic accidents. Damaged bowel results in loss of the normal gut barrier and flora can enter the tissue and even the blood. This concept of the "leaky gut" has been previously difficult to demonstrate. This can now be seen and measured using two new technologies called proteomics and confocal endomicroscopy. These tests offer new avenues of research for the 61,000 Australian sufferers of IBD.Read moreRead less
Utility Of Direct Endocardial Visualisation To Characterise Scar Morphology And Ablation Lesion Formation
Funder
National Health and Medical Research Council
Funding Amount
$421,285.00
Summary
Endocardial visualisation is a new technique in which a catheter is used to look at the internal surface of the heart without the need for surgery. We will use the visualisation catheter to find a better way of placing small burns within the heart to stop atrial fibrillation (one of the most common heart diseases). We will also use the visualisation catheter to find a better way of locating the scarred areas of the heart responsible for ventricular tachycardia (another common heart disease).
Efficacy Of Ablative Therapies For Barrett's Oesophagus
Funder
National Health and Medical Research Council
Funding Amount
$570,148.00
Summary
Some people with severe reflux develop Barrett's oesophagus, which puts them at high risk of developing cancer. Patients with Barrett's can be treated with various endoscopic ablation techniques, but it is not yet know if these treatments prevent the development of cancer. The aims of this work are to use molecular methods to ascertain whether the tissue that regenerates after ablation is normal, and to compare different ablation techniques.