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THE ROLE OF TUMOUR-EGRESSING T CELLS IN ANTI-TUMOUR IMMUNE RESPONSES
Funder
National Health and Medical Research Council
Funding Amount
$603,333.00
Summary
Immune cells can play both beneficial and detrimental roles in cancer. We have devised a novel method to ‘tag’ immune cells inside tumours and follow their fate. Using this method we discovered that immune cells called T cells can leave primary tumours and migrate to lymph nodes. The aim of this project is to investigate the role of these tumour-egressing cells in tumour immunity and to determine whether their migration and function can be manipulated to improve anti-tumour therapies.
Refugee Youth,Social Inclusion And Health: Social Networks, Education And Employment
Funder
National Health and Medical Research Council
Funding Amount
$108,234.00
Summary
The objectives of this research are to contribute to a deeper understanding of the issues of social inclusion for newly-arrived adolescent refugees in Australia by exploring the nature and extent of the social networks they experience. It will also assess the impact on social connectedness and socioeconomic disadvantage of an innovative program aimed at enhancing educational and employment opportunities for young people with refugee backgrounds.
Infection, Immunity And Immigration Models For Prevention And Control Of Infectious Diseases In Refugees
Funder
National Health and Medical Research Council
Funding Amount
$290,615.00
Summary
Australia accepts refugees on humanitarian grounds, with a high proportion of these currently from Africa and the Middle East and many have serious infections such as TB or malaria. The outcomes of refugee children with serious infections, and the relationship of these outcomes to a range of cultural, socio-demographic and clinical factors have not been widely studied in refugees. This research will enable development of a model for optimal care of refugee children with serious illness.
The Generation, Fate And Functional Potential Of Recent Thymic Emigrants
Funder
National Health and Medical Research Council
Funding Amount
$318,856.00
Summary
A particular kind of white blood cell, called a T lymphocyte, is responsible for controlling our immune responses to foreign invaders. These cells develop in the thymus, where they learn to distinguish between foreign invaders and self tissue, before emigrating to other organs. The regulation of this process is important to maintain a pool of T lymphocytes in the body. It is important that T lymphocytes do not respond against self tissue, as this can lead to a Oself destructO disease called auto ....A particular kind of white blood cell, called a T lymphocyte, is responsible for controlling our immune responses to foreign invaders. These cells develop in the thymus, where they learn to distinguish between foreign invaders and self tissue, before emigrating to other organs. The regulation of this process is important to maintain a pool of T lymphocytes in the body. It is important that T lymphocytes do not respond against self tissue, as this can lead to a Oself destructO disease called autoimmunity. Since these developing T lymphocytes will not see all kinds of self tissue while in the thymus, we propose that their education to prevent self-tissue reactivity may continue for some time after they leave the thymus.Read moreRead less
Peopling educational policy: realising the new Australian English and mathematics curricula. Implementation of Australian curricula in English and mathematics provides an opportunity for school systems to re-examine practice. This project will identify resources and teacher learning opportunities needed to facilitate implementation of these curricula and use findings to develop interventions identified as likely to optimise implementation.
The Lexicon Project: Analysing pedagogical naming systems from different cultures to reconceptualise classroom practice and advance educational theory. Classrooms remain the principal site of institutionalised learning. Their cultural specificity poses challenges for international comparative research. New approaches are needed. Internationally, our educational theories, research and descriptions of practice are framed in English, which names some aspects of the classroom, but ignores key aspect ....The Lexicon Project: Analysing pedagogical naming systems from different cultures to reconceptualise classroom practice and advance educational theory. Classrooms remain the principal site of institutionalised learning. Their cultural specificity poses challenges for international comparative research. New approaches are needed. Internationally, our educational theories, research and descriptions of practice are framed in English, which names some aspects of the classroom, but ignores key aspects named in other languages. This limits our capacity to access, connect and adapt the wisdom of other cultures. The Lexicon Project will initiate cross-cultural dialogue to identify pedagogical terms from selected Asian and European educational communities and use these as analytical tools to categorise, interrogate and enrich our classroom practice, classroom research, and educational theorising.Read moreRead less
Powerful knowledge: mapping out standards of teachers' knowledge for teaching mathematics and English to achieve the goals of the curriculum. Setting standards is an important step to raising teacher quality. This project will establish benchmarks for teachers' knowledge at all levels of schooling in two key areas of the curriculum: English and mathematics.
Sustainable Mathematical Foundations: STEM-enriched Modelling . This longitudinal project aims to generate new knowledge on how sustainable, innovative mathematics learning can be fostered through STEM-enriched mathematical modelling across the early grades. Featuring interdisciplinary processes, including engineering and science, novel modelling sequences will prompt children to adapt their existing ways of mathematical thinking to develop conceptual innovations in solving future-oriented pr ....Sustainable Mathematical Foundations: STEM-enriched Modelling . This longitudinal project aims to generate new knowledge on how sustainable, innovative mathematics learning can be fostered through STEM-enriched mathematical modelling across the early grades. Featuring interdisciplinary processes, including engineering and science, novel modelling sequences will prompt children to adapt their existing ways of mathematical thinking to develop conceptual innovations in solving future-oriented problems. New theoretical and empirical frameworks are expected to transform our outmoded problem experiences to ones that challenge all children to reach their mathematical potential. Professional learning, informed by international collaboration, is expected to transcend existing teacher development modes.Read moreRead less
Using mathematics to solve real world problems. This project aims to identify, apply and refine teaching approaches that help secondary students learn mathematical modelling, using mathematics to solve real world problems. The study will investigate the mathematical, cognitive, social and environmental factors that "enable" Year 10/11 students to develop mathematical representations of a real world problem. This project expects to generate theoretical and practical insights into how these enable ....Using mathematics to solve real world problems. This project aims to identify, apply and refine teaching approaches that help secondary students learn mathematical modelling, using mathematics to solve real world problems. The study will investigate the mathematical, cognitive, social and environmental factors that "enable" Year 10/11 students to develop mathematical representations of a real world problem. This project expects to generate theoretical and practical insights into how these enablers promote successful modelling, tasks that support students' development as modellers, and effective teaching approaches that promote student capability and interest in mathematics.Read moreRead less