Inhibition Of IFN-?/? By Human Metapneumovirus And The Induction Of Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$605,251.00
Summary
The newly isolated human metapneumovirus (hMPV) causes significant respiratory illness in infants, young children and the elderly. The virus can persist long-term and may predispose individuals to chronic lung disease. This proposal aims to determine the mechanisms by which hMPV infection causes respiratory disease, with a view to improving treatments and preventing disease.
Centre Of Research Excellence In Infectious Diseases Modelling To Inform Public Health Policy
Funder
National Health and Medical Research Council
Funding Amount
$2,600,064.00
Summary
Infectious diseases pose a global challenge, with substantial human and economic costs. Mathematical models provide valuable frameworks to assess likely benefits of interventions to control infection spread and burden. Leveraging existing NHMRC support, we will expand modeling capability to inform infectious disease control policy in Australia and our region. Focus areas include vaccine preventable disease, respiratory viruses and emerging pathogens, supported by innovative methods development.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Fluid-structural interactions in high-speed flows. This project aims to perform experiments to measure fluid-structure interaction in hypersonic flows. The work will improve the accuracy of simulation tools that are urgently required to aid industry in the design of more structurally efficient and robust high-speed vehicles. These tools will in turn be used to reveal the underlying physics of the fluid-structure interactions and establish the relative significance of the driving parameters. Accu ....Fluid-structural interactions in high-speed flows. This project aims to perform experiments to measure fluid-structure interaction in hypersonic flows. The work will improve the accuracy of simulation tools that are urgently required to aid industry in the design of more structurally efficient and robust high-speed vehicles. These tools will in turn be used to reveal the underlying physics of the fluid-structure interactions and establish the relative significance of the driving parameters. Accurate prediction of the behaviour and lifetime of structural components subject to these fluid-structural interactions, in which the deformation of the structure induced by the local flow field, can in turn influence this flow field. This coupling can result in damage or even catastrophic structural failure and thus robust design tools must be developed to avoid this.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100133
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
National Facility for Physical Blast Simulation (NFPBS). Recent terrorist attacks employing large quantities of high explosives have prompted the international demand for experimental investigation of civil infrastructure response to shock wave loadings. The National Facility for Physical Blast Simulation (NFPBS) is one of only a few in the world that are suitable for conducting experimental research via a physically generated blast approach.
A new energy absorption system for brain injury mitigation. This research aims to propose and investigate a next generation high-energy absorbing helmet pad that will protect the Australian Defence Force soldiers against both ballistic and blast threats. New fundamental knowledge in the area of high-energy absorbing metamaterials will be obtained by using numerical modelling and experimental studies. The expected outcomes of the project include the development of a new wearable energy absorbing ....A new energy absorption system for brain injury mitigation. This research aims to propose and investigate a next generation high-energy absorbing helmet pad that will protect the Australian Defence Force soldiers against both ballistic and blast threats. New fundamental knowledge in the area of high-energy absorbing metamaterials will be obtained by using numerical modelling and experimental studies. The expected outcomes of the project include the development of a new wearable energy absorbing pad which can be used as the next generation combat helmet liners and accessories. The novel high-performance energy absorption system will have a wide range of direct applications in future personal armour, as well as sports gears and elderly healthcare products.Read moreRead less
Human-Unmanned Aerial Vehicle interactions: Making drones talk and listen. This project aims to develop audio technology to enable unmanned aerial vehicles or drones to hear, use speech and sound to communicate with humans, acoustically sense their surroundings and make them less noisy. This project expects to generate new knowledge in acoustic signal processing and its application in drones using innovative approaches, such as use of miniature microphone and loudspeaker arrays, and active noise ....Human-Unmanned Aerial Vehicle interactions: Making drones talk and listen. This project aims to develop audio technology to enable unmanned aerial vehicles or drones to hear, use speech and sound to communicate with humans, acoustically sense their surroundings and make them less noisy. This project expects to generate new knowledge in acoustic signal processing and its application in drones using innovative approaches, such as use of miniature microphone and loudspeaker arrays, and active noise control. Expected outcomes include development of new theories, Intellectual Property, with potential commercial value, and training of next generation researchers. This should provide significant benefits with applications in life saving, search and rescue operations, transportation of goods, and creation of 3D media.Read moreRead less
Intriguing aerodynamics of bees, hoverflies and beyond. Nature observers have long been fascinated by the elegance, agility and endurance of flying insects, but still human-engineered vehicles fail to match their performance. This project aims to reveal the key physical aspects that allow two different insects to fly so well and thus unlock greater performance for flapping flight vehicles beyond insects.
Nonlinear topological photonics . The rapidly growing demands of information processing have launched a race for compact optical devices transmitting signals without losses. Topological phases of light provides unique opportunities to create new photonic systems with functionalities and efficiencies well beyond current capabilities. This project aims to develop new ways to generate and guide light at the nanoscale by merging fundamental concepts of nonlinear photonics and topological physics. Th ....Nonlinear topological photonics . The rapidly growing demands of information processing have launched a race for compact optical devices transmitting signals without losses. Topological phases of light provides unique opportunities to create new photonic systems with functionalities and efficiencies well beyond current capabilities. This project aims to develop new ways to generate and guide light at the nanoscale by merging fundamental concepts of nonlinear photonics and topological physics. The outcomes of this project will result in experimental demonstration of the world-first, highly efficient, compact, and lossless nonlinear photonic devices for advanced optical technologies.Read moreRead less
Electron Transpiration Cooling of Hypersonic Vehicles. Future aircraft for flight at hypersonic speeds require sharp leading edges for the best aerodynamic performance. Sharp leading edges incur high heat loads and cannot be adequately cooled with current technologies. The project aim is to investigate novel surface materials that emit electrons when heated. This emission of electrons from the surface can significantly contribute to the cooling of the sharp leading edges. This project is expecte ....Electron Transpiration Cooling of Hypersonic Vehicles. Future aircraft for flight at hypersonic speeds require sharp leading edges for the best aerodynamic performance. Sharp leading edges incur high heat loads and cannot be adequately cooled with current technologies. The project aim is to investigate novel surface materials that emit electrons when heated. This emission of electrons from the surface can significantly contribute to the cooling of the sharp leading edges. This project is expected to deliver new experimental data on novel surface materials exposed to a hypersonic flow environment and computer models that can simulate their cooling effect. This investigation will contribute towards enabling technologies for sustained hypersonic flight by overcoming critical head load limitations.Read moreRead less