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Endocrine signalling from bone cells in the regulation of glucose and energy homeostasis. Osteoporosis, obesity and diabetes are increasingly common, all of which are in urgent need of more effective therapies. This project examines powerful neuropeptide signalling pathways that integrate bone homeostasis with whole body energy and glucose balance. Initial studies have defined the efferent hypothalamic pathways of this system and this project will build upon these findings to examine the feedbac ....Endocrine signalling from bone cells in the regulation of glucose and energy homeostasis. Osteoporosis, obesity and diabetes are increasingly common, all of which are in urgent need of more effective therapies. This project examines powerful neuropeptide signalling pathways that integrate bone homeostasis with whole body energy and glucose balance. Initial studies have defined the efferent hypothalamic pathways of this system and this project will build upon these findings to examine the feedback signals produced by bone cells to regulate adipose and pancreatic function. Exploring this entirely new paradigm of skeletal biology, will reveal novel circulating factors capable of regulating adipose and glucose economies, as well as bone mass, thereby offering potential therapies for these debilitating conditions.Read moreRead less
Defining the pathways of developmental brain injury, for a healthy start to life. Injury to the developing brain, whether sustained during pregnancy or at birth, is the underlying cause of many cognitive and motor disabilities, including cerebral palsy. This project will identify the cellular pathways that cause developmental brain injury, arising from the three principal complications of pregnancy or birth; intrauterine growth restriction (IUGR), preterm birth with/without intrauterine infectio ....Defining the pathways of developmental brain injury, for a healthy start to life. Injury to the developing brain, whether sustained during pregnancy or at birth, is the underlying cause of many cognitive and motor disabilities, including cerebral palsy. This project will identify the cellular pathways that cause developmental brain injury, arising from the three principal complications of pregnancy or birth; intrauterine growth restriction (IUGR), preterm birth with/without intrauterine infection and birth asphyxia. This project will utilise this knowledge of the causal pathways leading to brain injury to implement targeted therapies to reduce injury or repair the brain. It will progress fundamental biomedical discoveries into clinical practice to decrease the incidence and severity of newborn brain injury and cerebral palsy.Read moreRead less
A new approach to reversing and preventing immune-mediated diseases. Chronic inflammatory diseases affect up to 20 per cent of Australians. These diseases reduce wellbeing and life potential and shorten lifespan. This project addresses the urgent need for effective therapies and focuses on developing strategies for disease cure and prevention.
From risk factor analysis to translation: multiple sclerosis and vitamin D deficiency. This research on multiple sclerosis will focus on its causes and lifestyle factors that affect it and will trial vitamin D supplementation as a treatment. Studies on vitamin D deficiency in healthy populations aim to develop new public health recommendations on sun exposure and vitamin D that balance risk of skin cancer against vitamin D deficiency.
Alphaherpesvirus vaccination, recombination and latency; a study in the natural host. Attenuated alphaherpesvirus vaccines are used widely in production and companion animals to help control disease. These vaccines help to prevent clinical signs of disease following challenge with virulent viruses. There is also the potential to use these vaccines to help prevent latent herpesvirus infections, and to limit the opportunities for herpesvirus recombination to occur. This would enhance the ability t ....Alphaherpesvirus vaccination, recombination and latency; a study in the natural host. Attenuated alphaherpesvirus vaccines are used widely in production and companion animals to help control disease. These vaccines help to prevent clinical signs of disease following challenge with virulent viruses. There is also the potential to use these vaccines to help prevent latent herpesvirus infections, and to limit the opportunities for herpesvirus recombination to occur. This would enhance the ability to control disease in animal populations. This project aims to systematically study how vaccines may be used to limit latency and recombination events by studying avian infectious laryngotracheitis virus in the natural host leading to new insights into how vaccines may be used more efficaciously.Read moreRead less
Stress-sensing and cytoprotection in ageing and disease. This project aims to unravel the mechanisms responsible for age- and disease-related responses to heart attacks and the efficacy of therapeutic approaches, while deepening our understanding of a novel, potent protective modality effective in aged hearts. This program will provide valuable basic knowledge, leading to more efficacious therapies.
Determining how calcium regulates mitochondrial function in models of cardiomyopathy. Heart failure is the leading cause of death in Australia. This project will determine the mechanisms by which the failing heart is associated with disorganisation of the cell and poor energy supply so that interventions aimed at reducing the development of heart failure can be developed.
What shapes our brain? This project aims to improve our fundamental understanding of the biological mechanisms that drive folding of the cerebral cortex, which occurs during development of the brain. Cortical folding is unique to humans and higher mammals, and is thought to underpin the emergence of intelligence and contribute to higher-order brain functions. This project will enhance knowledge of how the cerebral cortex folds and develop novel tools for analysing brain development. The project ....What shapes our brain? This project aims to improve our fundamental understanding of the biological mechanisms that drive folding of the cerebral cortex, which occurs during development of the brain. Cortical folding is unique to humans and higher mammals, and is thought to underpin the emergence of intelligence and contribute to higher-order brain functions. This project will enhance knowledge of how the cerebral cortex folds and develop novel tools for analysing brain development. The project will provide significant benefits including the generation of fundamental knowledge with implications for future understanding of cortical folding abnormalities in babies born preterm, following fetal growth retardation in utero, or when exposed to maternal alcohol. In the longer term, the project will contribute to improvements to human neurodevelopment and brain health.Read moreRead less
Development of new interventions and treatment for schistosomiasis morbidity control. Australia has played a lead role in Parasitology research. It is vital to remain at the forefront in combating the human and livestock diseases that parasites cause. Vaccine assessment and the large scale analysis of patient tissues are vital to the biotechnology, agriculture and pharmaceutical industries with outcomes leading to innovative strategies for control. Politically there is value as it is altruistic ....Development of new interventions and treatment for schistosomiasis morbidity control. Australia has played a lead role in Parasitology research. It is vital to remain at the forefront in combating the human and livestock diseases that parasites cause. Vaccine assessment and the large scale analysis of patient tissues are vital to the biotechnology, agriculture and pharmaceutical industries with outcomes leading to innovative strategies for control. Politically there is value as it is altruistic to develop new tools, technologies and treatments for the Asia/Pacific region. Economically, Australia will have first pass at developing the intellectual property arising. As well, the therapies would be developed locally to the benefit of Australia's human therapeutics industry and bio-reagent manufacturers.Read moreRead less
Improving the quality of life of children born very premature. This research program is in line with the national research priority to promote good health and well being, and more specifically to provide a healthy start to life for high-risk infants. This research program is attempting to improve the quality of life of infants born very preterm by improving our understanding of the nature of the problems faced by these high-risk children. This knowledge will inform future preventative care and ....Improving the quality of life of children born very premature. This research program is in line with the national research priority to promote good health and well being, and more specifically to provide a healthy start to life for high-risk infants. This research program is attempting to improve the quality of life of infants born very preterm by improving our understanding of the nature of the problems faced by these high-risk children. This knowledge will inform future preventative care and early intervention strategies. More directly, this research program incorporates a series of randomised controlled trials which are all attempting to improve the health and well being of these vulnerable infants.Read moreRead less