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Media Formulations To Enhance Embryo Formation In Assisted Reproduction
Funder
National Health and Medical Research Council
Funding Amount
$660,133.00
Summary
The increasing age of parenthood has led to an explosion in the demand for assisted reproductive technologies such as in vitro fertilisation (IVF). This procedure has a poor success rate and is limited by the ability of fertilised eggs to mature into early embryos in the lab prior to being transferred into women. We will develop new compounds that improve embryo growth in the clinic, which will improve IVF success rates.
The Functional Roles Of ADAMs In The Regulation Of Embryo Implantation.
Funder
National Health and Medical Research Council
Funding Amount
$211,527.00
Summary
The initiation of pregnancy in humans and rodents hinges upon the ability of the embryo to attach to the wall of the uterus and invade into the uterine tissue. This process of embryo implantation is tightly regulated and depends on the secretion of enzymes and regulators of these enzymes. A newly identified family of enzymes which might be important in this process is the ADAMs family. These enzymes have the potential to facilitate both cell attachment and cell invasion and also to activate othe ....The initiation of pregnancy in humans and rodents hinges upon the ability of the embryo to attach to the wall of the uterus and invade into the uterine tissue. This process of embryo implantation is tightly regulated and depends on the secretion of enzymes and regulators of these enzymes. A newly identified family of enzymes which might be important in this process is the ADAMs family. These enzymes have the potential to facilitate both cell attachment and cell invasion and also to activate other enzymes and growth factors. Recent studies in our laboratory have shown the ADAMs to be expressed both at the most invasive time of implantation and when invasion is being down-regulated. This project will examine the role of the ADAMs in embryo implantation facilitating attachment and invasion into the uterus by acting enzymatically on the uterine tissue and by activating other enzymes. It will also determine the role of ADAMs in down-regulating invasion potentially by activating a growth factor, TNF-alpha. Knowledge of this process and particularly its regulation is important for the treatment of pregnancy associated diseases that arise from improper implantation. These include infertility, placenta accreta, choriocarcinoma, miscarriage and pre-eclampsia. Furthermore, an understanding of the regulation of implantation will contribute to the treatment of other conditions associated with cell invasion such as cancer metastasis.Read moreRead less
A nation of 'Good Sports'? Cultural citizenship and sport in contemporary Australia. Australia is widely regarded as both characterised and united by sport, but the established sport-nation nexus is undergoing significant change. This project addresses current uses and meanings of sport, media and spectatorship in advancing knowledge and policy relating to sport's dynamic relationship to national identity and cultural citizenship.
Communicating with people who have limited English proficiency. This sociolinguistic project aims to investigate how fluent English speakers interact with people who have limited proficiency. In contemporary Australia such mundane interactions may determine employment, education or health outcomes. While research into language barriers has mostly focused on the experiences of migrants from non-English-speaking backgrounds, this project will investigate how English speakers deal with increasing l ....Communicating with people who have limited English proficiency. This sociolinguistic project aims to investigate how fluent English speakers interact with people who have limited proficiency. In contemporary Australia such mundane interactions may determine employment, education or health outcomes. While research into language barriers has mostly focused on the experiences of migrants from non-English-speaking backgrounds, this project will investigate how English speakers deal with increasing linguistic diversity. Expected outcomes include an understanding of the role of majority members in facilitating the integration of newcomers. This will provide significant socioeconomic benefits for institutions and individuals as they navigate everyday intercultural communication.Read moreRead less
Voice, indexicality and the mediation of diversity on Australian television. Multicultural Australia is a country of many voices, although concern has been expressed about the under-representation of those voices in the media. This project investigates how the voices of minority groups are represented on mainstream Australian television, when they do appear. It examines a substantial body of TV data, from four types of programming: news, sports, advertising and drama. It focuses on minority ethn ....Voice, indexicality and the mediation of diversity on Australian television. Multicultural Australia is a country of many voices, although concern has been expressed about the under-representation of those voices in the media. This project investigates how the voices of minority groups are represented on mainstream Australian television, when they do appear. It examines a substantial body of TV data, from four types of programming: news, sports, advertising and drama. It focuses on minority ethnic voices and on voices linked to different social classes. Close analysis of media processes will be supplemented by consulting professionals and TV viewers. The findings will provide a new perspective on the media’s role in promoting or curtailing cultural literacy and linguistic diversity.Read moreRead less
Germaine Greer, celebrity and popular feminism. This project aims to evaluate Germaine Greer’s contribution to popular understandings of feminism. It will use newly available archival material to examine Greer's global influence as a celebrity feminist. The project will assess Greer’s writing and its effect on her audiences, her interventions into various forms of media, and how her public persona has been constructed including her own role in this process. It will consider why she remains such ....Germaine Greer, celebrity and popular feminism. This project aims to evaluate Germaine Greer’s contribution to popular understandings of feminism. It will use newly available archival material to examine Greer's global influence as a celebrity feminist. The project will assess Greer’s writing and its effect on her audiences, her interventions into various forms of media, and how her public persona has been constructed including her own role in this process. It will consider why she remains such a highly visible and contested feminist figure. This project expects to understand how feminist ideas circulate in the public domain.Read moreRead less
The couple: commitment and durability in the era of marriage equality. This project aims to examine the notion of the couple in the era of marriage equality. It is generally thought that couple longevity is an incontestable good socially, psychologically, and economically. The advent of same-sex marriage in Australia provides the occasion to reconsider why it is that general cultural benefits are thought to devolve from coupled intimacy alone. Rather than dismiss the value of marriage, either st ....The couple: commitment and durability in the era of marriage equality. This project aims to examine the notion of the couple in the era of marriage equality. It is generally thought that couple longevity is an incontestable good socially, psychologically, and economically. The advent of same-sex marriage in Australia provides the occasion to reconsider why it is that general cultural benefits are thought to devolve from coupled intimacy alone. Rather than dismiss the value of marriage, either straight or gay, this project looks at an archive of contemporary representations in which the couple form presents as a public good, not a private good. This anthropological study tests the supposed connection between intimate companionship and collective thriving.Read moreRead less
Reconceiving the queer public sphere: an interdisciplinary analysis of same-sex couple domesticity. Using literary, biographical and photographic sources, this project will produce a ground-breaking history of same-sex domestic environments across the twentieth century. Critically analysing queer home life, this project will transform current understandings of the relation between homosexuality, private life and the public sphere.
Governing Prostitution in the People's Republic of China. This project will generate knowledge for 'Understanding Our Region and the World', part of the National Research Priority-Safeguarding Australia. It will do so by producing the first detailed study of the governmental regulation of prostitution in present-day China. Its impact will be increased knowledge of different, local responses to the governance of prostitution businesses and practices. It will position Australian research at the in ....Governing Prostitution in the People's Republic of China. This project will generate knowledge for 'Understanding Our Region and the World', part of the National Research Priority-Safeguarding Australia. It will do so by producing the first detailed study of the governmental regulation of prostitution in present-day China. Its impact will be increased knowledge of different, local responses to the governance of prostitution businesses and practices. It will position Australian research at the international forefront of this field, thereby enabling Australian researchers to lead and contribute to international policy debate on prostitution, public health issues and related government regulation.Read moreRead less
Locating LGBTIQ+ youth in the archive: Telling new stories for belonging. This project aims to produce the first study of LGBTIQ+ youth in Australia’s past and investigate what these histories mean to LGBTIQ+ youth today. We will generate new knowledge of Australian LGBTIQ+ history and links between historical knowledge and wellbeing in relation to LGBTIQ+ youth. Working with LGBTIQ+ youth we will also develop new archival storytelling techniques, theorising archives as ‘laboratories of belongin ....Locating LGBTIQ+ youth in the archive: Telling new stories for belonging. This project aims to produce the first study of LGBTIQ+ youth in Australia’s past and investigate what these histories mean to LGBTIQ+ youth today. We will generate new knowledge of Australian LGBTIQ+ history and links between historical knowledge and wellbeing in relation to LGBTIQ+ youth. Working with LGBTIQ+ youth we will also develop new archival storytelling techniques, theorising archives as ‘laboratories of belonging’. In doing so, the project forges links between cultural studies of storytelling, LGBTIQ+ youth studies and Australian history. Benefits include innovations in reparative historical methodologies, new resources for the GLAM, youth and education sectors and improvements in LGBTIQ+ youth wellbeing.Read moreRead less