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Interleukin 11 And Leukaemia Inhibitory Factor: Important Regulators Of Embryo Implantation And Placentation
Funder
National Health and Medical Research Council
Funding Amount
$346,117.00
Summary
Infertility, spontaneous abortion and pre-eclampsia are major clinical problems. Interleukin (IL)-11 and leukemia inhibitory factor (LIF) are critical for embryo implantation in mice but their roles in women are unknown. I will define their roles in the establishment of pregnancy and provide new critical information on their potential as targets for diagnostic and therapeutic tools for infertility and major diseases associated with pregnancy.
Optimising Female Fertility: Controlling Ovulation And Promoting Embryo Developmental Potential
Funder
National Health and Medical Research Council
Funding Amount
$459,270.00
Summary
A good quality egg at the right time is required to make a healthy embryo, influencing its lifetime health trajectory. My research aims to determine how the female ovary produces a good quality egg and releases it at the right time. This is essential for improving reproductive health in women and will identify how maternal health influences egg quality and the earliest stages of embryo growth, providing the healthiest start to life.
Novel Pathomechanisms And Therapeutic Targets In Neurodegenerative Diseases
Funder
National Health and Medical Research Council
Funding Amount
$340,038.00
Summary
This fellowship will provide new insight into the molecular processes underlying onset and progression of common brain conditions, including Alzheimer’s disease, frontotemporal dementia and motor neuron disease. Furthermore, new therapeutic targets for these diseases will be developed and tested in model systems, to facilitate future translation into clinical application, and to overcome the lack of treatments.