Clinical Features, Neurophysiology And Histopathology Of Peripheral Neuropathy In Children With Mitochondrial Disease
Funder
National Health and Medical Research Council
Funding Amount
$56,200.00
Summary
Peripheral neuropathies are frequently associated with mitochondrial diseases in children and cause progressive weakness and gait abnormalities and could result in loss of ambulation. This study aims to characterise the clinical spectrum and range of electrophysiological and histopathological abnormalities in the peripheral nerves of children with mitochondrial neuropathies to provide a resource that enables early diagnosis and implementation of rehabilitative measures.
Can Persistent Bladder Pain Be Treated By Targeting TRPA1 Expressing Nociceptors?
Funder
National Health and Medical Research Council
Funding Amount
$687,730.00
Summary
Persistent visceral pain is extremely difficult to treat and manage. To solve this problem we need to understand how pain nerves in internal organs differ from those in skin and muscle. We have discovered a pain-detecting molecule TRPA1 in bladder sensory nerves. We aim to show how bladder inflammation changes the function of these bladder pain detectors and test a new way of selectively anesthetising them. We also will use a new technique to study how the bladder lining detects pain.