Structural Characterisation Of The Co-inhibitory Complex Formed By The Tumour Suppressor PTEN And The Metastatic Factor PREX2
Funder
National Health and Medical Research Council
Funding Amount
$563,602.00
Summary
Metastasis is a major cause of cancer mortality. Characterisation of key proteins that regulate metastasis is therefore a priority. PTEN and PREX2 are enzymes that play key roles in metastasis in melanoma, and other cancers. We will determine the structural basis of PTEN:PREX2 co-inhibition, and determine how cancer-associated PREX2 mutations dysregulate this inhibitory complex. This study will provide the necessary knowledge for future drug development programs targeting PTEN:PREX2 in cancer.
Structural And Functional Characterisation Of The Oncogene P-Rex1
Funder
National Health and Medical Research Council
Funding Amount
$623,447.00
Summary
The spread of cancer to other parts of the body (metastasis) is a major cause of mortality. The characterisation of proteins that regulate metastasis is therefore a priority. P-Rex1 plays a crucial role in promoting metastasis in breast and other cancers. We will determine the structural basis of P-Rex1 activity, and investigate how its dysregulation promotes aberrant cell growth. This study will provide the knowledge to build future drug development programs targeting P-Rex1 in cancer.
Targeting NDM-producing ‘superbugs’: Optimising Novel Combinations With ‘old’ Polymyxins Using Pharmacological, Molecular Imaging And Systems Biology Approaches
Funder
National Health and Medical Research Council
Funding Amount
$582,732.00
Summary
Rapid global spread of so-called NDM-producing bacterial ‘superbugs’ is presenting a major medical challenge. Without new antibiotics under development, polymyxin is becoming the only effective antibiotic. Unfortunately we recently revealed that treatment with polymyxin alone can rapidly lead to resistance in NDM-producing ‘superbugs’. This project will employ new tools to optimise rational polymyxin combinations, thereby providing urgently needed information to clinicians for treating these ver ....Rapid global spread of so-called NDM-producing bacterial ‘superbugs’ is presenting a major medical challenge. Without new antibiotics under development, polymyxin is becoming the only effective antibiotic. Unfortunately we recently revealed that treatment with polymyxin alone can rapidly lead to resistance in NDM-producing ‘superbugs’. This project will employ new tools to optimise rational polymyxin combinations, thereby providing urgently needed information to clinicians for treating these very problematic infections.Read moreRead less
A Structural Understanding Of Class B G Protein-coupled Receptor Function
Funder
National Health and Medical Research Council
Funding Amount
$1,289,570.00
Summary
G protein-coupled receptors (GPCRs) are the largest family of cell surface proteins that enable communication from external signals to the inside of cells of the body. Class B GPCRs are a therapeutically important subclass of these receptors and they play crucial roles in bone and energy homeostasis, cardiovascular control and immune response. This grant will uncover fundamental knowledge on how these receptors work, and will enhance future development of therapeutics.
Structural Events In Insulin And IGF Signalling - A Nanodisc Approach To A Problem In Cancer, Diabetes And Alzheimer's Disease
Funder
National Health and Medical Research Council
Funding Amount
$752,403.00
Summary
Insulin and its insulin-like growth factors play a major role in three major disease states facing ageing Australians—diabetes, cancer and Alzheimer's disease. We aim to understand how these proteins send messages into cells via their so-called receptors. We will isolate the receptor molecules from cells and then image them in an advanced electron microscope to produce three-dimensional images. Our findings will have implications for the design of therapeutics targeting the above three diseases.
Combining mathematical programming and constraint programming to solve large-scale integrated scheduling problems. This project will target major savings in the airline industry, with resulting benefits for others such as tourism. The efficient use of airline fuel, which will be directly addressed in the project, is very important for the environment. The algorithms developed can improve cost and quality of service for Australian transportation, manufacturing and other industries.
The solut ....Combining mathematical programming and constraint programming to solve large-scale integrated scheduling problems. This project will target major savings in the airline industry, with resulting benefits for others such as tourism. The efficient use of airline fuel, which will be directly addressed in the project, is very important for the environment. The algorithms developed can improve cost and quality of service for Australian transportation, manufacturing and other industries.
The solutions developed within the project will be sold by the industrial partner, CTI, into major companies worldwide, and the technology will be used to develop further products.
Finally the project will extend Australia's lead in constraint programming and expertise in optimisation. This creates a major opportunity for the Australian software industry.
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From Tactical Planning to Operational Control - Bridging the Chasm. All organisations plan, and all organisations suffer from the disruptions that occur when plans are put into practice. Few organisations manage to balance operational control with planning to as to maintain both efficiency and flexibility to deal with the unexpected. This project addresses this requirement for the transportation and logistics industries.
The results discovered within the project will enable the industrial ....From Tactical Planning to Operational Control - Bridging the Chasm. All organisations plan, and all organisations suffer from the disruptions that occur when plans are put into practice. Few organisations manage to balance operational control with planning to as to maintain both efficiency and flexibility to deal with the unexpected. This project addresses this requirement for the transportation and logistics industries.
The results discovered within the project will enable the industrial partner, CTI, to develop solutions for major companies worldwide. The technology will be used to build further optimisation products.
Moreover the project will extend Australia's lead in constraint programming and expertise in optimisation. This creates a major opportunity for Australia's software industry.
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Optimising the design and implementation of public transport priority initiatives. This project strengthens national approaches to a pervasive Australian problem, growing traffic congestion deteriorating liveability, environmental health & economic performance of the cities where most Australians live. Public transport can address these issues but most is provided by buses which are caught up in traffic congestion. This project improves approaches for traffic priority design to improve the eff ....Optimising the design and implementation of public transport priority initiatives. This project strengthens national approaches to a pervasive Australian problem, growing traffic congestion deteriorating liveability, environmental health & economic performance of the cities where most Australians live. Public transport can address these issues but most is provided by buses which are caught up in traffic congestion. This project improves approaches for traffic priority design to improve the effectiveness and efficiency of on-road public transport. It optimises the design of individual and groups of priority treatments and will generate diagnostic tools to better target priority treatments. Findings will better focus Australia's approach to increasingly challenging transport futures.Read moreRead less
The future of shipping: achieving autonomous navigation. This project aims to develop autonomous decision systems and onshore control stations to support the design and operation of unmanned cargo ships. Blending observations, numerical models, virtual reality and machine learning, the project will develop algorithms for unsupervised navigation and embed these in an advanced ship simulator platform capable of responding to environmental conditions and optimising sea freight transport capabilitie ....The future of shipping: achieving autonomous navigation. This project aims to develop autonomous decision systems and onshore control stations to support the design and operation of unmanned cargo ships. Blending observations, numerical models, virtual reality and machine learning, the project will develop algorithms for unsupervised navigation and embed these in an advanced ship simulator platform capable of responding to environmental conditions and optimising sea freight transport capabilities. The expected outcomes will enable the integration of automated controls in ships, including remote-control capabilities. This will support Australia’s transition towards an autonomous shipping industry, delivering greater reliability, efficiency, productivity and safety.Read moreRead less
The development of active third-generation heavy vehicle aerodynamic drag reducing devices to reduce future transport emissions. The potential for emission reductions through aerodynamic improvements is particularly apparent in long haul heavy vehicle transport. By developing active devices to be fitted to the heavy vehicle trailer of the future this work offers drag reduction potential from current levels of up to 40 per cent. If widely implemented these devices could play a major part in the t ....The development of active third-generation heavy vehicle aerodynamic drag reducing devices to reduce future transport emissions. The potential for emission reductions through aerodynamic improvements is particularly apparent in long haul heavy vehicle transport. By developing active devices to be fitted to the heavy vehicle trailer of the future this work offers drag reduction potential from current levels of up to 40 per cent. If widely implemented these devices could play a major part in the transport sector meeting medium term emissions targets. If successful not only will the project develop unique components, it will support heavy vehicle research and development that is so important to maintaining a strong manufacturing presence in Australia, especially in regional centres, such as Ballarat where Maxitrans has major headquarters. Read moreRead less