Engineering and testing of three mode opto-acoustic parametric amplifiers. This project will engineer a new type of sensor called an opto-acoustic parametric amplifier. It is so sensitive to measure individual quantum units of vibration. The devices use laser light to measure the motion of tiny mirrors. Practical devices could be used to create quantum memory for quantum computers and sensors of exquisite sensitivity.
A new tool for comprehensive label-free micro-imaging of cancer in situ. This project aims to engineer a new micro-imaging tool for comprehensive characterisation of the tumour microenvironment in situ, including micro-morphology, microvasculature, extracellular matrix, local stiffness and the functional variables of pH, oxygen content and temperature. The project will provide accessible, label-free longitudinal monitoring of tumours in animal models of disease; thereby, reducing animal use, imp ....A new tool for comprehensive label-free micro-imaging of cancer in situ. This project aims to engineer a new micro-imaging tool for comprehensive characterisation of the tumour microenvironment in situ, including micro-morphology, microvasculature, extracellular matrix, local stiffness and the functional variables of pH, oxygen content and temperature. The project will provide accessible, label-free longitudinal monitoring of tumours in animal models of disease; thereby, reducing animal use, improving experimental power, and providing better micro-scale characterisation to underpin discovery and application in cancer biology. With potential for translation to humans and commercialisation, such a tool will ultimately contribute to improved diagnosis and treatment of cancer.Read moreRead less
Nanoscope-in-a-needle: nanoscale imaging and sensing deep inside tissue. This project seeks to make possible nanoscale and microscale imaging deep inside living human tissue. By miniaturising advanced optical imaging, sensing and spectroscopy systems into a hypodermic needle – a nanoscope-in-a-needle – it would be possible to study the structure and function of living biological systems in their native, three-dimensional environment up to centimetres deep in soft tissue but with unprecedented n ....Nanoscope-in-a-needle: nanoscale imaging and sensing deep inside tissue. This project seeks to make possible nanoscale and microscale imaging deep inside living human tissue. By miniaturising advanced optical imaging, sensing and spectroscopy systems into a hypodermic needle – a nanoscope-in-a-needle – it would be possible to study the structure and function of living biological systems in their native, three-dimensional environment up to centimetres deep in soft tissue but with unprecedented nano- and micro-scale resolution. A suite of new nanoscopes would underpin biological discovery and help advance human health and wellbeing.Read moreRead less