A Prospective Study To Examine The Effectiveness And Safety Of Antivirals Against Pandemic Influenza
Funder
National Health and Medical Research Council
Funding Amount
$142,394.00
Summary
Pandemic influenza could cause significant mortality in populations of Australia and the south-east Asian region. Currently, avian influenza A (H5N1) is a concern to public health agencies because of its extreme pathogenicity. At present this strain is not transmitted readily between humans. A number of drugs are available to treat influenza infection in humans and research has shown these to be effective in preventing significant mortality in the setting of seasonal influenza epidemics (specifi ....Pandemic influenza could cause significant mortality in populations of Australia and the south-east Asian region. Currently, avian influenza A (H5N1) is a concern to public health agencies because of its extreme pathogenicity. At present this strain is not transmitted readily between humans. A number of drugs are available to treat influenza infection in humans and research has shown these to be effective in preventing significant mortality in the setting of seasonal influenza epidemics (specifically the influenza neuraminidase inhibitors _NIs). As a consequence public health agencies around the world have been stockpiling these drugs and developing sophisticated plans for their use if an influenza pandemic was announced. However, there are no data indicating that the neuraminidase inhibitors (NIs) are safe and effective when used to manage pandemic influenza. Neither are there any data to support the use of these drugs on a population basis. Genetic resistance to NIS has been described but it is not clear if this has any relevance to public health. Our research will clarify this issue. This project will develop a number of clinical trials that could be implemented rapidly should pandemic influenza ever be announced by health authorities in Australia-Singapore or Hong Kong. Patients with suspected influenza infection will be asked to provide informed consent prior to commencing NI therapy. Clinical information will then be collected for a period of approximately one month along with some blood samples and swabs from the throat and nasal passages. Data will be analysed as quickly as possible to help inform the continued use of NI therapy as a cornerstone of the public health agency response to pandemic influenza. In addition, the study team will prepare clinical trials to be conducted in essential workers who are likely to receive long-term NI preventive treatment as well as the immediate contacts of people with presumed influenza infection who are likely to receive short-term prophylaxis with NIs.Read moreRead less
Efficacy Of Treatment For Resistant Command Hallucinations.
Funder
National Health and Medical Research Council
Funding Amount
$343,875.00
Summary
Auditory hallucinations (AHs), often described as voices, are a common symptom of schizophrenia and psychoses. Command hallucinations (CHs) are a type of AH in which the voice heard by the patient commands him or her to perform a particular action. The nature of the directive may vary from inconsequential actions to commands to harm the patient or others. There is widespread public concern about the danger individuals with schizophrenia or related disorders pose to themselves and to the communit ....Auditory hallucinations (AHs), often described as voices, are a common symptom of schizophrenia and psychoses. Command hallucinations (CHs) are a type of AH in which the voice heard by the patient commands him or her to perform a particular action. The nature of the directive may vary from inconsequential actions to commands to harm the patient or others. There is widespread public concern about the danger individuals with schizophrenia or related disorders pose to themselves and to the community. There is firm evidence pointing to the important role that CHs play in propelling psychotic individuals into serious and damaging actions. We have found, however, that most individuals who comply with dangerous CHs do so, not because they are angry, violent, antisocial or wish to cause harm, but because they feel powerless to resist. Though CHs are one of the most disturbing symptoms of psychosis, standard treatment has proved to be of limited benefit. This study will evaluate the effectiveness of Treatment of Resistant Command Hallucinations (TORCH), an innovative treatment for CHs. TORCH is an extension of an existing treatment for psychosis that we previously developed. TORCH aims to reduce the distress, worry and harmful or self-defeating behaviour associated with CHs by arming the patient with effective strategies that will enhance resistance and reduce compliance. The project has clear implications for improved clinical and therapeutic management of CHs with major public health, clinical and forensic repercussions. The consequences of being formally assessed as being at risk of acting violently result in the potential for substantial restrictions on the freedom of the individual. The availability of TORCH may prompt a less restrictive management of individuals at risk of dangerous behaviour and promote a more optimistic attitude amongst clinicians. Relatives and carers also stand to benefit through reduction in perplexing and fear-inducing behaviours.Read moreRead less
Guiding Intervention Choices To Reduce Health Costs, Health Inequalities, And Improve The Health Of Australians
Funder
National Health and Medical Research Council
Funding Amount
$3,200,000.00
Summary
As health care costs rise, governments increasingly will need objective evidence on the benefits and costs of health intervention options, whilst taking into account the need for greater health equity, transparency of decision making and stakeholder acceptability. This project will provide the health intelligence to guide such health priority setting in Australia, with a focus on prevention of non-communicable diseases, the implications for Indigenous Australians and the most efficient ways of i ....As health care costs rise, governments increasingly will need objective evidence on the benefits and costs of health intervention options, whilst taking into account the need for greater health equity, transparency of decision making and stakeholder acceptability. This project will provide the health intelligence to guide such health priority setting in Australia, with a focus on prevention of non-communicable diseases, the implications for Indigenous Australians and the most efficient ways of implementing priority interventions in primary care.Read moreRead less
Burden Of Disease&cost Effectiveness Of Intervention Options:informing Policy Choices & Health System Reform In Thailand
Funder
National Health and Medical Research Council
Funding Amount
$787,978.00
Summary
This research project aims to improve the scientific basis for health services provision in Thailand by filling important gaps in knowledge about the causes of disease and the possibility of effectively intervening to reduce them. Since the accuracy of the routine death registration system in Thailand is unknown, it cannot be confidently used to guide policy. The team will evaluate how accurately causes of death are being recorded, both in urban and rural areas. It will also calculate how much d ....This research project aims to improve the scientific basis for health services provision in Thailand by filling important gaps in knowledge about the causes of disease and the possibility of effectively intervening to reduce them. Since the accuracy of the routine death registration system in Thailand is unknown, it cannot be confidently used to guide policy. The team will evaluate how accurately causes of death are being recorded, both in urban and rural areas. It will also calculate how much disease and injury in Thailand is being caused by major risk factors, such as tobacco and unsafe sex. Using this information the team will evaluate the effectiveness of the major interventions to reduces diseases and injuries from risk factors that are affordable and applicable in the Thai context.Read moreRead less
Preventive messages and guidelines to reduce sitting — especially prolonged periods of sitting — have emerged. However, what prolonged sitting should be replaced with, and the feasibility of making real world changes to this behaviour, is unknown. This program of research will provide high quality evidence on the benefits of reducing prolonged sitting time, and the effectiveness and acceptability of achieving sitting reductions in real-world contexts.
Harnessing The Power Of Elite Sport Sponsorship To Promote Healthy Eating By Young Adults
Funder
National Health and Medical Research Council
Funding Amount
$304,220.00
Summary
Concerns have been raised about the role of unhealthy food sponsorship of elite sport in promoting unhealthy diets to vast numbers of the public, including young adults who are avid spectators of sport. This innovative project consists of two studies which systematically investigate the utility of alternative, health-oriented sport sponsorship models and counter-advertising strategies in promoting healthier diets among young adults.
Quantifying The Effectiveness Of Pertussis Vaccine In Older Adults
Funder
National Health and Medical Research Council
Funding Amount
$448,703.00
Summary
Pertussis is the most poorly controlled vaccine preventable disease in Australia. Childhood pertussis is a well-known public health problem but adult pertussis is also common and has a significant burden on the health system, especially in adults over 65 years. Pertussis vaccines for adults are currently not funded by our national immunisation program. This project will provide vital data to inform whether pertussis vaccination is cost-effective in older Australian adults.
Early Life And Contemporary Influences On Body Composition, Mental Health, And Chronic Disease Risk Markers In The Aboriginal Birth Cohort
Funder
National Health and Medical Research Council
Funding Amount
$3,117,044.00
Summary
The Aboriginal Birth Cohort study has been following the health of Aboriginal babies in the Northern Territory for the last 30 years. The participants were healthy till adolescence, but overweight and risk factors of diseases such as diabetes, kidney and heart disease are emerging. This follow-up will show when and whether these risk factors develop into disease, which factors are protective and which identify early those most at risk of developing diseases that cause the gap in life expectancy.
Pharmaceutical Opioid Prescription For Chronic Pain In Australia: Trajectories Of Prescribing, Risk Of Adverse Events, And Predictors Of Harm
Funder
National Health and Medical Research Council
Funding Amount
$1,086,274.00
Summary
There is concern about rising levels of opioid analgesic prescribing in Australia. This study is important because it will provide evidence about long term outcomes for patients using opioid therapy for chronic non-malignant pain. It will examine prescribing patterns and link them to other health outcomes such as overdose. We will also study patients beginning opioid therapy for chronic pain and follow them up over 2 years to examine outcomes such as pain relief and medication side effects.
A Solution Based Approach Developing Child Health Research With A Focus On Preventive Interventions For Common Childhood
Funder
National Health and Medical Research Council
Funding Amount
$2,599,538.00
Summary
There is an increasing recognition that research into child health should focus not only on disease but also on common childhood disorders such as obesity, depression and poor literacy. In addition, such research should include solution-based activity. That is, child health research should have an active program of testing new interventions to prevent the onset of disorders, or to allow optimal early management. The Murdoch Childrens Research Institute, the largest Australian child health resear ....There is an increasing recognition that research into child health should focus not only on disease but also on common childhood disorders such as obesity, depression and poor literacy. In addition, such research should include solution-based activity. That is, child health research should have an active program of testing new interventions to prevent the onset of disorders, or to allow optimal early management. The Murdoch Childrens Research Institute, the largest Australian child health research institute, is in a very good position to develop Australia's capacity further with regard to a coordinated research program into preventative interventions in child health. This is because of: - the Institute's location at the Royal Children's Hospital, Melbourne, the largest paediatric health service provider in Australia - the many individual relevant research projects that are already occurring in MCRI - the strong existing teams of researchers with skills in many different fields of child health such as psychology, speech pathology, clinical-medical care, epidemiology and biostatistics, and laboratory science including genetics. This capacity building program will coordinate population health work to develop the knowledge and skills of eight population health researchers. This development will occur within the context of an internationally competitive research program with structured continuing education and training to promote public health leadership. The capacity building program will develop skills not only in study design, conduct and analysis, but also in collaboration and the translation of research findings into better health services, government policy and parental knowledge to prevent problems and improve the health and well being of children and their families. To care for children in the best way, parents, families, schools, health care providers, and government need the best evidence base possible on the prevention of common child disorders.Read moreRead less