Surveillance And Treatment Of Prisoners With Hepatitis C (SToP-C)
Funder
National Health and Medical Research Council
Funding Amount
$1,560,494.00
Summary
SToP-C will investigate whether a significant reduction in hepatitis C infection in NSW prisons is possible with a “treatment as prevention” strategy. It will treat prisoners for hep C infection both to improve their own health and to make onward transmission to others less likely. There is currently a lack of available effective strategies; however through delivery of simple, effective new therapies this world-first trial offers significant opportunities to reduce the burden of liver disease.
Community Treatment Intervention With Ivermectin To Reduce The Prevalence Of Scabies And Strongyloides
Funder
National Health and Medical Research Council
Funding Amount
$109,046.00
Summary
Scabies and strongyloides are endemic in many remote East Arnhem Aboriginal communities. To reduce the prevalence of these parasitic infections a community treatment intervention will be undertaken using the drug Ivermectin. The introduction of this innovative drug treatment regime for both scabies and strongyloides will be a first in Australia.
Treatment And Prevention Of HIV And Sexually Transmitted Infections
Funder
National Health and Medical Research Council
Funding Amount
$772,490.00
Summary
My research will use statistical and mathematical models to answer questions in the prevention and treatment of infectious diseases. I will assess long-term outcomes in HIV positive patients, including developing risk prediction models to improve patients monitoring. I will look at strategies to improve antiretroviral treatment in developing countries in Asia. And I will identify optimal preventions strategies to reduce rates of sexually transmitted infections.
Novel Artemisinin-based Combination Therapies For Children Exposed To High Transmission Of Multiple Plasmodium Species
Funder
National Health and Medical Research Council
Funding Amount
$1,378,408.00
Summary
We recently found that the WHO-recommended combination antimalarial therapy artemether-lumefantrine and the candidate regimen dihydroartemisinin-piperaquine were not fully effective for both falciparum and vivax malaria in young PNG children, a group at risk of complications and death. We plan to study two new combinations (artesunate-pyronaridine and artemisinin-naphthoquine) and hypothesise that at least one will prove superior and be used as first-line treatment in PNG and similar countries.
Understanding, Detecting, Monitoring And Treating Brain Dysfunctions Due To Chronic Immune Diseases
Funder
National Health and Medical Research Council
Funding Amount
$415,219.00
Summary
The role of immune burdens on the brain of middle-aged persons is not well understood. For example the combined brain effects of HIV and cardio-vascular diseases are unknown. Our research is about better understanding those processes using advanced neuropsychology and brain imaging methods. It is also about developing new instruments to detect problems as early as possible, to monitor them accurately and to better treat them in Australia and the Asia-Pacific region.
A Study Of Factors That May Influence The Neurocognitive Health Of HIV+ Populations: For Better- Early Antiretroviral Therapy? For Worse- Cardiovascular Risk Factors And Disease?
Funder
National Health and Medical Research Council
Funding Amount
$362,123.00
Summary
Cognitive health is of primary importance to HIV affected communities. Recently high blood pressure and high cholesterol have been associated with poor cognitive performance in middle aged HIV+ patients. We plan to study whether HIV+ patients with cardiovascular risk factors have faster and more frequent cognitive decline than HIV+ and HIV- patients without these risk factors. In another study we plan to determine the potential benefits of early versus deferred HIV antiretroviral therapy upon ne ....Cognitive health is of primary importance to HIV affected communities. Recently high blood pressure and high cholesterol have been associated with poor cognitive performance in middle aged HIV+ patients. We plan to study whether HIV+ patients with cardiovascular risk factors have faster and more frequent cognitive decline than HIV+ and HIV- patients without these risk factors. In another study we plan to determine the potential benefits of early versus deferred HIV antiretroviral therapy upon neurocognitive performance.Read moreRead less
Understanding And Preventing Chronic Disease In People Living With HIV
Funder
National Health and Medical Research Council
Funding Amount
$367,946.00
Summary
Australia’s ageing population is increasingly at risk of chronic diseases such as heart disease and diabetes. For Australians who are living with HIV, these diseases occur more frequently and at an earlier age. I will be investigating the underlying reasons for this increase in risk and will test innovative online systems that help people living with HIV reduce their risk of chronic disease. This work will provide important information for Australians at risk of developing chronic disease.
Adapting Pandemic Influenza Interventions And Management To The Newly-emerged Virus
Funder
National Health and Medical Research Council
Funding Amount
$245,098.00
Summary
The Australian Health Management Plan for Pandemic Influenza is based on data from past and current influenza. A newly-emerged influenza strain is likely to differ in some respects. This project will develop practical ways to adapt the management plan to the emerged virus from early pandemic data. It will determine the data needed to do this efficiently, to ensure that Australia receives the greatest benefit from its antiviral drugs, vaccines and other public health interventions introduced.