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Understanding The Impact Of Social, Economic And Geographic Disadvantage On The Health Of Australians In Mid - Later Lif
Funder
National Health and Medical Research Council
Funding Amount
$1,943,571.00
Summary
This research will examine the ways in which social, economic and environmental factors contribute to the health of Australians in mid to later life. It will help identify ways in which policy and preventive programs can contribute to improving health in mid to later life particularly among disadvantaged Australians. We will explore in detail social, economic and environmental factors in 100,000 people aged 45 and over; this will be the largest study of its kind ever undertaken in Australia. We ....This research will examine the ways in which social, economic and environmental factors contribute to the health of Australians in mid to later life. It will help identify ways in which policy and preventive programs can contribute to improving health in mid to later life particularly among disadvantaged Australians. We will explore in detail social, economic and environmental factors in 100,000 people aged 45 and over; this will be the largest study of its kind ever undertaken in Australia. We will examine the relationship between these social, economic factors, and lifestyle factors such as smoking, physical activity, environmental and obesity. This will enable us to identify where programs and policies should be directed to most rapidly improve the health of disadvantaged Australians.Read moreRead less
Ensuring The Sustainability Of Care For People With Dementia Now And Into The Future
Funder
National Health and Medical Research Council
Funding Amount
$717,063.00
Summary
Ensuring adequate the funding of appropriate and timely care is available for people living with dementia is a key concern for the public and for governments. This research will develop new methods of measuring the effectiveness and cost-effectiveness of treatments and care packages for people with dementia. This will help ensure the sustainability of our health and social care system into the future by directing scarce resources into programs most likely to be of benefit.
Improving Mental Health For Young People In Out-of-home Care: Providng Participatory Evidence-based Mental Health Care Across Services
Funder
National Health and Medical Research Council
Funding Amount
$956,114.00
Summary
Young people in out-of-home care have experienced traumas and adversities. They are highly vulnerable to mental ill-health and associated problems with relationships, education and meaningful activity. The project aims to deliver evidence-based mental health support and care across the health and community service system relevant to these young people in Victoria. The aim is to work in partnership to reduce the risks of mental ill-health and support more effective treatment and recovery.
An Integrated Health-sector Strategy To Combat COPD And Asthma In Vietnam: A Pragmatic Stepped Intervention Cluster Randomized Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,894,349.00
Summary
Chronic lung diseases are a major challenge for resource limited settings. In Vietnam, where smoking rates in males are around 50%, there is an urgent need for better strategies to prevent and treat chronic obstructive pulmonary disease (COPD) and asthma. We will perform a study of a low-cost integrated intervention including a health-system based smoking cessation program and the targeted use of proven therapy for COPD and asthma - inhaled corticosteroids - to reduce the burden of lung disease.
N-glycan Profiling As A Risk Stratification Biomarker For Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$549,644.00
Summary
This study sets out to establish an N-glycan biomarker profile of suboptimal health in a well-established cohort of adult Australians, the Busselton Healthy Ageing Study (BHAS) and Chinese (SHS cohort) . This biomarker profile will contribute to the future development of N-glycan traits as a tool for (i) risk prediction of chronic disease onset, in particular those chronic conditions that constitute type II diabetes mellitus, and (ii) the prediction of a patient’s response to treatment.
An Investigation Into The Neural Substrates Of Cognitive Deficits In Mild Cognitive Impairment, And The Mechanisms Of Action Of A Novel Treatment
Funder
National Health and Medical Research Council
Funding Amount
$574,644.00
Summary
Furthering our understanding of the brain mechanisms that underlie the deficits in memory, executive function, and language that occur with Mild Cognitive Impairment is vital for conceptualising the underlying disease processes, and for the development of targeted treatments. Hence, this project will conduct a comprehensive assessment of the brain’s electrical and metabolic responses during specialised cognitive tasks, whilst simultaneously investigating a possible treatment.
This project will investigate the causes of respiratory disease and poor lung function across the life course. Using existing lung health data from Australia and Europe, we will determine which behavioral, environmental, occupational, nutritional, other modifiable lifestyle, or genetic factors play a role in lung health. This research will enable the development of a personalised risk predictor application for implementation with patients and health care providers as well as the general public.
A Suite Of Engineered Human Pluripotent Stem Cell Lines To Facilitate The Generation Of Hematopoietic Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$881,221.00
Summary
Our goal is to develop tools that address major bottlenecks that have prevented the generation of blood forming stem cells in culture for therapeutic use. We will generate human embryonic stem cell reporter lines that can be used to monitor key milestones in blood stem cell development. These lines will serve as tools to identify growth conditions to improve the differentiation of pluripotent stem cells to functional blood stem cells.
Kidney Mesenchymal Stem Cells In Tubular Development, Repair And Turnover
Funder
National Health and Medical Research Council
Funding Amount
$989,141.00
Summary
In Australia, 11.3% of deaths are associated with chronic kidney disease with >$1 billion per annum spent on treating this condition. At present, only dialysis and transplantation are available to treat end stage kidney disease. We have found a kidney stem cell population in both human and mouse that can form new epithelial structures. In this project, we will investigate the normal role played by these kidney stem cells and examine whether they can contribute to kidney regeneration.
E-PREDICE Early Prevention Of Diabetes Complications In Europe
Funder
National Health and Medical Research Council
Funding Amount
$917,400.00
Summary
The e-PREDICE study will randomise 3000 people aged 45-74 with mild hyperglycaemia or early diabetes to treatment with intensive lifestyle modification alone, or plus metformin, or sitagliptin, or liraglutide, aiming to reduce diabetes eye, kidney and nerve damage. The Australian arm will be co-ordinated by the University of Sydney and other sites include Baker IDI Heart and Diabetes Institute, Royal Melbourne Hospital, St Vincent’s Hospital Melbourne and Royal Brisbane and Womens Hospital