GM-CSF Regulation Of Preimplantation Embryo Development
Funder
National Health and Medical Research Council
Funding Amount
$481,320.00
Summary
Treatment of infertility using IVF technology has been enormously successful. However, there are major concerns regarding the high incidence of multiple pregnancies (caused by the transfer of more than one embryo) and the potential adverse health outcome of adults conceived from this technology. Multiple pregnancies place both mother and infant at enormous risks, with increased obstetrics care, prematurity, increased neonatal care and neurological disorders such as cerebral palsy. This can be ov ....Treatment of infertility using IVF technology has been enormously successful. However, there are major concerns regarding the high incidence of multiple pregnancies (caused by the transfer of more than one embryo) and the potential adverse health outcome of adults conceived from this technology. Multiple pregnancies place both mother and infant at enormous risks, with increased obstetrics care, prematurity, increased neonatal care and neurological disorders such as cerebral palsy. This can be overcome simply by the transfer of a single embryo. However, patient and clinical expectations are that single embryo transfer should be achieved with little to no reduction in pregnancy rate, and currently this is not possible because our methods for culturing embryos are inadequate. Studies in animals suggest that laboratory growth of mammalian embryos can lead to small-for-gestational age babies (even when the effect of multiple births is taken into consideration). This backed by recent studies which agree that babies born from IVF are smaller than expected. This might lead to health problems in later life, as smallness at birth is associated with higher risks of cardiovascular disease and diabetes, especially as age progresses beyond 40 years. However, the oldest IVF child is currently 23 years of age. Previously we have shown that a protein growth factor, called granulocyte-macrophage colony-stimulating factor (GM-CSF), found normally in the reproductive tract, has dramatic beneficial effects on human and mouse embryos grown in the laboratory. Furthermore, we have shown in mice that embryo exposure to GM-CSF alleviates the detrimental side effects of in vitro culture on foetal growth and body structure after birth. Our research is now focussed on understanding why this protein is beneficial to embryo growth and to test if we can increase pregnancy rates and produce normal healthy infants from the transfer of single embryos treated with GM-CSF.Read moreRead less
Early Detection Of Infants And Young Children With Autism
Funder
National Health and Medical Research Council
Funding Amount
$268,250.00
Summary
Autism is a severely handicapping condition adversely affecting social interaction, communication, behaviour, interests, and activities. Autism requires treatment at an early age (before 4 years). Despite finding that parents notice problems with their child's development within the first 2 years, on average diagnoses are made around 6 years of age. Treatment for autism should begin as early as possible to improve outcome. Diagnosis requires specialist assessment and these services are limited. ....Autism is a severely handicapping condition adversely affecting social interaction, communication, behaviour, interests, and activities. Autism requires treatment at an early age (before 4 years). Despite finding that parents notice problems with their child's development within the first 2 years, on average diagnoses are made around 6 years of age. Treatment for autism should begin as early as possible to improve outcome. Diagnosis requires specialist assessment and these services are limited. Therefore it is not possible to undertake such assessments with all children who have developmental problems. This project therefore proposes to evaluate a method for screening large populations of children for autism, thus enabling timely and more appropriate referral to assessment services. Previous work by the investigators has developed a potential screening tool (DBC Early Screen) for autism in young children under 4 years with developmental delay that has high levels of accuracy in identifying those infants and children who are at risk of autism and require specialist assessment. This project proposes to undertake a community field trial to assess the accuracy and reliability of this early screen and to establish its suitability for wide use as a population screening tool. The preliminary testing of DBC Early Screen demonstrated that a community field trial was feasible. The results of this study will facilitate the referral of infants and young children to specialist autism assessment services, thus enabling the commencement of appropriate early intervention for children and their families from an early age.Read moreRead less
Long-term Efficacy Of An Oral Health Promotion Program In The Prevention Of Early Childhood Caries.
Funder
National Health and Medical Research Council
Funding Amount
$165,664.00
Summary
The aim of the project is to test the long-term efficacy of oral health promotion program, the purpose of which is to lower the prevalence of tooth decay among young children. Tooth decay affects approximately 1 in 6 children by age of 3 years and 1 in 2 children by age of 5 years. The disease negatively influences all aspects of quality of life of child. Tooth decay is associated with infection, pain, and frequent hospitalisation. The proposed project is a follow-up of an randomised controlled ....The aim of the project is to test the long-term efficacy of oral health promotion program, the purpose of which is to lower the prevalence of tooth decay among young children. Tooth decay affects approximately 1 in 6 children by age of 3 years and 1 in 2 children by age of 5 years. The disease negatively influences all aspects of quality of life of child. Tooth decay is associated with infection, pain, and frequent hospitalisation. The proposed project is a follow-up of an randomised controlled trial (RCT), which started with enrolment of pregnant women. They were randomised into the test and control groups. Mothers in test group received 3 round of preventive oral health information in the form of anticipatory guidance, the first round at enrolment, the second and third at 6, 12 months of age of child respectively. The information was mailed to their home address. All children were examined at age of 20 months of age. The children in the test group had lower prevalence of tooth decay compared to children in control group, (test group 1,7%, control group 9.6%). While the oral health information was effective in preventing decay at 20 months, longer-term follow-up is highly desirable. Therefore, we plan to follow-up the oral health of the children at 5 - 6 years old. It is anticipated, that 75% mothers from the trial will be contactable and will continue with their participation in the study. A third comparative group of children at the same age will be drawn from database of the South Australian School Dental Services to check if the children in the trial are representative of all SA school children. All children will be examined by dentists or school dental therapists after they enter school. The prevalence of the tooth decay and its mangement will be examined and compared among children from test and control groups and children from community.Read moreRead less
Attracting, preparing, and sustaining quality teachers in early education. This project aims to address the chronic shortage of early childhood teachers in Australia, which is compromising quality and return on investment in early education. The project expects to generate new understandings about this specialist teacher workforce through an innovative, ecological, longitudinal design that will track early childhood teachers’ career trajectories and develop a world-first tool to assess early chi ....Attracting, preparing, and sustaining quality teachers in early education. This project aims to address the chronic shortage of early childhood teachers in Australia, which is compromising quality and return on investment in early education. The project expects to generate new understandings about this specialist teacher workforce through an innovative, ecological, longitudinal design that will track early childhood teachers’ career trajectories and develop a world-first tool to assess early childhood teacher quality. Findings are expected to inform policy— including the Australian Government-endorsed 10-year national Workforce Strategy and the Australian Government's Early Years Strategy— to support the future sustained supply of a quality early childhood teacher workforce and improve outcomes for young children.Read moreRead less
Identification Of The Molecular Hallmarks Of Naevi Progressing To Melanoma
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Melanomas are amongst the most commonly occurring cancers in Australia with >136,000 people living with a previous melanoma diagnosis. One of the highest risk factors for developing melanoma is having a high number of moles (or naevi). It is therefore important to fully understand how and why naevi develop into melanoma. It is hoped that early detection markers will be identified which will help identify early melanomas and as such improve patient outcome.
Early Detection And Early Intervention For Cerebral Palsy
Funder
National Health and Medical Research Council
Funding Amount
$2,088,220.00
Summary
Cerebral Palsy (CP) is Australia’s 5th expensive health condition. Early Detection and effective early interventions are vitally needed to improve long-term outcomes. This fellowship develops and tests novel interventions to optimise neuroplasticity by improving early detection and physical, cognitive, psychological and health outcomes in children with CP. Earlier accurate detection of CP will ensure effective treatments utilise critical periods of brain development.
Enabling Personalised Risk Assessment For Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Bowel cancer screening will be most effective in disease prevention if it is applied proportionately to individual person's risk. Risk-based screening requires a risk calculator to assess personal risk. By utilising existing large, international datasets, I will identify the risk factors specific for different bowel cancer types and incorporate them to upgrade the prediction model that I have developed. This will achieve more accurate risk prediction to enable personalised risk-based screening.
Peer Delivered Early Intervention For Infants At High Risk Of Cerebral Palsy In Indigenous Australia
Funder
National Health and Medical Research Council
Funding Amount
$286,891.00
Summary
This study explores the effectiveness of early detection and intervention for infants at risk of cerebral palsy in Indigenous Australia. Infants will be detected by 3 months, and randomly assigned to one of two intervention groups; home-based peer-delivered multi-domain intervention, or health advice. Infants receiving the novel intervention are expected to have improved developmental outcomes, and caregivers improved mental health.