ARDC Research Link Australia

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $606,015.00
Summary: Genes have recently been identified which, when abnormal, result in an inherited tendency towards developing breast cancer (BC). It is now possible to undergo testing for abnormalities in these genes. However, there is little known about the best ways to prevent cancer or detect it early in individuals with such a gene abnormality. In addition, it is possible that BCs occuring in women with a gene abnormality might behave differently (have a different prognosis and thus require different treatme ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $510,675.00
Summary: Having a strong family history of breast cancer is one of the most important risk factors for the disease. Two major genes, BRCA1 and BRCA2, have been identified which, when abnormal, result in an inherited tendency towards developing breast cancer. Women with a strong family history of breast cancer can undergo testing for these gene abnormalities via Family Cancer Centres around Australia. However, once a gene abnormality is found, little is known about the best ways to prevent cancer or detec ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $1,338,436.00
Summary: SNAC1 compares two operations for assessing cancer spread to the lymph nodes in women with early breast cancer: 1) axillary clearance and 2)sentinel node biopsy. Axillary clearance involves removal of most lymph nodes in the armpit. In sentinel node biopsy only a few lymph nodes most closely related to the breast cancer are removed. The trial will determine if sentinel node biopsy reduces lymphoedema and gives equivalent cure rates. If it does, then it should become standard practice.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $240,187.00
Summary: Over 13,000 ANZ women are diagnosed with breast cancer each year. Most need surgery to remove the cancer and determine if it has spead to glands in the armpit (axillary lymph nodes). Knowing whether the cancer has spread to the axillary lymph nodes helps determine prognosis and plan treatment. Surgical removal is the most reliable way to assess the axillary lymph nodes. SNAC1 compares two operations for assessing cancer spread to the lymph nodes in women with early breast cancer: 1) axillary cle ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $345,931.00
Summary: Mammographic density (MD), is a major risk factor for breast cancer. The nature of breast tissue underlying MD is not clear. The study will clarify the nature of breast tissue underlying MD as well as determining the breast MRI and ultrasound features that correlate with MD. These findings will enhance knowledge of breast cancer development, and should help to avoid mammography to screen young, high risk women and fulfil a priority objective of Cancer Australia

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $32,003.00
Summary: The aim of this project is determine how best to measure, analyse and compare the effects of different operations for women with breast cancer. This will be done with information on measurements of arm swelling, symptoms, functions, and other aspects of quality of life collected in over 1,000 women taking part in a national randomised trial. This research will provide important information about the effects of these operations, and about how best to design future surgical trials.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $519,330.00
Summary: Hormone therapy is very effective for treating prostate cancer however it produces a number of side effects including muscle and bone loss, fat gain, and increased risk of death from heart disease and diabetes. In other populations physical exercise has proven particulary effective for preventing such problems however no long term studies with prostate cancer patients have ever confirmed this. Knowledge gained from this study has potential to markedly reduce suffering and increase survival.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $326,761.00
Summary: Gastric cancer is the fourth ranked cancer by mortality in Australia. Therapy of gastric cancer is unsatisfactory for two reasons; firstly, how normal stomach cells become cancerous is not well defined. We know long-term infection with the bacteria Helicobacter can lead to these cancers, as can severe acid reflux. The cancers produced by these very different agents look remarkably similar, but must be arising through different pathways. Research to date has not yielded great insight. Secondly, e ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $1,266,430.00
Summary: SNAC2 extends the work begun in SNAC1, which recruited 1,088 women over 4 years. SNAC1 will determine if sentinel node biopsy causes less arm problems than axillary clearance. The goal of SNAC2 is to establish the risk of local recurrence and long term safety of sentinel node biopsy, especially for women with larger or multiple tumours. SNAC2 is needed to determine whether the smaller operation gives cure rates as good as axillary clearance. If it does, then it will become standard practice.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $304,794.00
Summary: A significant proportion of ovarian cancer patients and their partners experience elevated levels of distress. Determining if particular services, diet or exercise are effective in alleviating this distress will help to inform service provision and clinical practice. This research approaches this issue by firstly evaluating use of psychosocial services, diet and exercise in relation to quality of life, and secondly by piloting a lifestyle intervention for patients and partners with distress.

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