Early Detection And Early Intervention For Cerebral Palsy
Funder
National Health and Medical Research Council
Funding Amount
$2,088,220.00
Summary
Cerebral Palsy (CP) is Australia’s 5th expensive health condition. Early Detection and effective early interventions are vitally needed to improve long-term outcomes. This fellowship develops and tests novel interventions to optimise neuroplasticity by improving early detection and physical, cognitive, psychological and health outcomes in children with CP. Earlier accurate detection of CP will ensure effective treatments utilise critical periods of brain development.
Reducing Colorectal Cancer Burden In Young Adults: Precision Prevention And Early Detection
Funder
National Health and Medical Research Council
Funding Amount
$1,449,800.00
Summary
Bowel cancer rate in young adults before age 50 is increasing worldwide including Australia. Since it is impossible to screen everyone, it is critical to identify who is likely to develop the disease, to optimise screening. Using the world's largest resource for young-onset bowel cancer, I will conduct studies to generate high-quality evidence to inform how to best prevent bowel cancer in young adults and translate into the policy and practice, to reduce colorectal cancer burden in young adults.
Developing Interpretable Machine Learning Models For Clinical Imaging And Single-cell Genomics
Funder
National Health and Medical Research Council
Funding Amount
$1,312,250.00
Summary
Machine learning methods will be vital to make best use of the deluge of data generated by high-throughput technologies in biomedical science. To get the most out of these models, however, we need to be able to unpack the 'black box'. I will use curated clinical and public research data to benchmark and develop interpretable deep learning models and software tools. These models will be used for breast cancer screening programs and for analysis of complex, large-scale single-cell genomics data.
Genetics Of Epilepsy: Completing Our Understanding
Funder
National Health and Medical Research Council
Funding Amount
$3,000,000.00
Summary
Finding genetic causes of epilepsies is vital for accurate diagnosis and family counseling, to optimize current treatments and to develop novel therapies. We will leverage our large collection of carefully evaluated Australian cases with international data sets, coordinated by Consortia that I chair, to develop a detailed understanding of the genetic causes of epilepsy. This will transform the use of genetics in the clinic, lead to better immediate treatment and aid in developing novel therapies
Next Generation Of Medical Devices And Diagnostics
Funder
National Health and Medical Research Council
Funding Amount
$2,738,220.00
Summary
This Investigator Project will deliver innovative technologies that improve patient wellbeing, make significant economic impact and contribute to answering complex biological questions. This will happen via delivering breakthrough technologies to prevent infections and diagnose diseases – two area that currently require substantial technological advances. In addition to helping patients and clinicians, the project will also deliver solid body of new knowledge that is currently missing.
An In Vitro Pipeline For Liquid Biopsy Biomarkers For Cancer Diagnosis And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$3,764,215.00
Summary
A droplet of blood contains information whether a person has cancer, the stage of the cancer and how their response to treatment. The proposed research will employ ultrasensitive detection technologies to analyse so-called biomarkers released from cancer cells. We will use lab-based models of cancer, generated with a 3D bioprinter, to learn what biomarkers tell us about cancer type and response to drugs. This knowledge is urgently needed for early cancer detection and better cancer treatment.
Unified Prevention Of Substance Use And Mental Disorders.
Funder
National Health and Medical Research Council
Funding Amount
$2,560,520.00
Summary
Substance use and mental disorders are among the leading causes of burden of disease in young people globally. Yet prevention and early intervention has not been prioritised in Australian research and policy.The major focus of my research will be on examining the effectiveness of new unified prevention programs.
Transforming Access To Addiction Treatment: Overcoming System Barriers And Developing Effective Early Intervention Approaches
Funder
National Health and Medical Research Council
Funding Amount
$2,195,288.00
Summary
Addiction is one of the most highly stigmatised disorders in our community, resulting in a near two decade delay before people seek treatment. Although individuals with alcohol and drug problems present many times to health services, there are multiple missed opportunities for intervention. This research will identify opportunities to facilitate early help-seeking and treatment via insights through data linkage and machine learning, as well as testing novel telephone-based models of care.