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Centre For Clinical Research Excellence In Anxiety And Neuroscience
Funder
National Health and Medical Research Council
Funding Amount
$2,007,200.00
Summary
This Centre will bring together Australia's leading anxiety and neuroscience researchers to develop, evaluate, and disseminate better treatments of anxiety. Epidemiological studies indicate that anxiety disorders are common, with lifetime prevalence estimated to be as high as 15% (1). These disorders share the features of excessive physiological arousal in response to feared stimuli, and this leads to pervasive avoidance that has a debilitating impact on people's lives. In addition, anxiety is o ....This Centre will bring together Australia's leading anxiety and neuroscience researchers to develop, evaluate, and disseminate better treatments of anxiety. Epidemiological studies indicate that anxiety disorders are common, with lifetime prevalence estimated to be as high as 15% (1). These disorders share the features of excessive physiological arousal in response to feared stimuli, and this leads to pervasive avoidance that has a debilitating impact on people's lives. In addition, anxiety is often present as a co-morbid feature of other major disorders, such as schizophrenia, substance use, and depression. Anxiety is one of the world's major health burdens; it costs $44 billion per year in the United States. Health agencies around the world are now putting unprecedented resources into understanding the neural bases of anxiety and its reduction. Building on recent advances in the neuroscience of anxiety, the Centre will expand the capacity for neurotransmitter modulation during therapy to reduce anxiety disorders. By extensive training programs with community clinicians, the Centre will conduct large-scale community trials to assess effectiveness of new approaches. The Centre will foster a new generation of neuroscience researchers and clinicians who are skilled in translating basic science findings into clinical practice.Read moreRead less
An Integrated Model Of Environmental, Neurodevelopmental, And Epigenetic Resistance And Responsiveness To Early Intervention In Childhood Psychopathology.
Funder
National Health and Medical Research Council
Funding Amount
$846,110.00
Summary
The foundations of mental health problems are present early in life. This project will map stability and change in a sample of children with common mental health problems receiving an intervention targeting the quality of the home environment. It will produce a road map of how the child’s strengths and vulnerabilities are affected by treatment, protect against future mental health problems, and suggest new intervention targets for children who fail to benefit from existing treatments.
People with psychotic illness, even with good treatment, do not tend to make functional recovery. They are over represented among the unemployed, the homeless, and have poorer physical health and earlier death than the general population. Despite the significant personal, societal and economic cost of these poor outcomes there has been little research into these areas. This fellowship builds on my work in vocational recovery to broaden knowledge about, and interventions for, functional recovery ....People with psychotic illness, even with good treatment, do not tend to make functional recovery. They are over represented among the unemployed, the homeless, and have poorer physical health and earlier death than the general population. Despite the significant personal, societal and economic cost of these poor outcomes there has been little research into these areas. This fellowship builds on my work in vocational recovery to broaden knowledge about, and interventions for, functional recovery in first episode psychosis.Read moreRead less
Enhancing Social Functioning In Young People At Ultra High Risk (UHR) For Psychosis: RCT Of A Novel Strengths-based Online Social Therapy
Funder
National Health and Medical Research Council
Funding Amount
$1,543,657.00
Summary
Psychosis is a devastating mental health disorder that results in great personal suffering and enormous societal costs. Early intervention is seen as the most promising treatment approach with potential to bring about long-term recovery. The aims of this project are to assess the effectiveness of a highly novel strengths-based online social media intervention in preventing psychosocial deterioration and improve social functioning in young people at ultra high risk of developing psychosis.
Does Antipsychotic Dose Reduction Lead To Better Functional Recovery In First Episode Psychosis: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$2,371,552.00
Summary
Can a person with a first episode of psychosis, once remitted, reduce their dosage of medication and still achieve better outcomes in functioning, physical health and brain volume, than if they had stayed on traditional maintenance doses of medication? This study will examine if using a dose reduction strategy in conjunction with an evidence based suite of psychosocial interventions leads to better social and vocational recovery and improved physical health and brain volume.
Rates Of Psychosis Onset In A High Risk Population
Funder
National Health and Medical Research Council
Funding Amount
$310,359.00
Summary
Older studies of people at risk of schizophrenia found that about 35% of them developed psychosis within 1 year. However the risk has decreased lately to as low as 10%. They may still become psychotic but take longer to do so, or they may not develop psychosis at all. We need to study this so that those not “at risk” are not needlessly treated. We will follow up “at risk” people and determine their 6 year outcome. We will do scans to see if there are any brain changes associated with psychosis.
Connecting The Dots: Novel Social Media Technologies For Long-term Functional Recovery In First Episode Psychosis
Funder
National Health and Medical Research Council
Funding Amount
$432,528.00
Summary
The aim of this program of research is to evaluate the effectiveness of innovative online social media and mobile-based interventions purposely designed to improve long-term recovery in youth mental health (i.e., early psychosis and youth depression). These pioneering interventions have been designed by a large multidisciplinary team through the integration of cutting-edge social media technologies, new psychological models and strong consumer-youth participation.
FETAL ORIGIN OF ADULT DISEASE? A POPULATION-BASED STUDY OF THE OFFSPRING OF WOMEN WITH SEVERE MENTAL DISORDERS
Funder
National Health and Medical Research Council
Funding Amount
$442,875.00
Summary
Fetal origin of adult disease is a currently influential paradigm in epidemiological research into common diseases (ischaemic heart disease, hypertension, diabetes) and behaviour problems (suicide, criminal offending). It postulates an early pathophysiological programming of outcomes that become manifest in adult life. In the proposed research we aim to examine key aspects of this model by conducting a population-based study on the developmental outcomes, antecedent and concomitant risk factors, ....Fetal origin of adult disease is a currently influential paradigm in epidemiological research into common diseases (ischaemic heart disease, hypertension, diabetes) and behaviour problems (suicide, criminal offending). It postulates an early pathophysiological programming of outcomes that become manifest in adult life. In the proposed research we aim to examine key aspects of this model by conducting a population-based study on the developmental outcomes, antecedent and concomitant risk factors, and a spectrum of neuropsychiatric morbidity in all children (N-5150) born in Western Australia in 1980-2001 to women diagnosed with schizophrenia, bipolar affective disorder or unipolar depression, as compared to children (N-504,553) born to women without a diagnosed psychiatric illness. The study will be based on record linkage, utilising the unique resource of multiple, comprehensive population databases in Western Australia. Specifically, this research will identify the range of developmental outcomes and morbidity in four consecutive birth cohorts (1980-84; 1985-89; 1990-94; and 1995-2001) of children at high genetic and environmental risk and examine their relationship to specific risk factors, including familial genetic load, obstetric complications, severity of maternal illness, and psychosocial adversity. The study will be the first of its kind and its findings will inform aetiological research into the major mental disorders, as well as clinical and public health practice. It will provide novel data on fundamental issues, such as the interaction between genetic risk and environmental factors in the causation of schizophrenia, as well as on the extent to which the risk of developing severe mental illness is immutably embedded in its fetal origin, or is modifiable by subsequent mitigating factors and appropriate intervention.Read moreRead less
An MRI Study Of Emotional Processing Deficits In Childhood
Funder
National Health and Medical Research Council
Funding Amount
$578,985.00
Summary
The ability to recognise and process emotions in other people is fundamental to healthy social interactions. Conduct disordered children with callous and unemotional traits have difficulty recognizing fearful expressions, possibly due to lack of attention to cues such as facial expressions that healthy people naturally attend to. This study will use neuroimaging to determine if brain activity changes to look more like typically developing children if their gaze is redirected to facial cues of em ....The ability to recognise and process emotions in other people is fundamental to healthy social interactions. Conduct disordered children with callous and unemotional traits have difficulty recognizing fearful expressions, possibly due to lack of attention to cues such as facial expressions that healthy people naturally attend to. This study will use neuroimaging to determine if brain activity changes to look more like typically developing children if their gaze is redirected to facial cues of emotion.Read moreRead less