Active Lung Disease In Survivors Of Preterm Birth? Can We Treat It?
Funder
National Health and Medical Research Council
Funding Amount
$612,862.00
Summary
More than 15 million babies are born preterm each year. Those that survive face a lifetime of ongoing breathing problems and lung function that worsens through childhood. Our study will work out how inflammation in the lungs contributes to these ongoing breathing problems during childhood. We will also look at how the exhaled breath of preterm children is different to term children and test how treatment with an inhaled anti-inflammatory medicine changes the lung disease in preterm children.
Understanding And Improving Treatment Of Premature Infants To Improve Long Term Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$638,517.00
Summary
The last 2 decades heralded many important advances in the care of preterm infants but important gaps in our knowledge remain. Studies undertaken in the preclinical and clinical settings during this Fellowship will enhance understanding of the complex nature of disease in preterm infants. Further, we will develop and evaluate new treatments that enhance growth and development of the premature baby to optimise their long term intellectual, physical, emotional and social outcomes.
Predicting The Long Term Lung Health Outcomes In Young Adults Born Very Preterm
Funder
National Health and Medical Research Council
Funding Amount
$854,201.00
Summary
Preterm birth and its resulting lung problems can lead to breathing problems during childhood and into adult life. There are very few lung health studies that have tracked preterm individuals from childhood and into early adult life. This study will conduct a detailed lung health assessment in a follow-up of a group of preterm individuals at 19 years of age. We aim to identify if information we obtained in the group at 6 and 11 years can predict how the lungs look and behave at 19 years of age.
Bronchopulmonary Dysplasia – A Regenerative Medicine Approach
Funder
National Health and Medical Research Council
Funding Amount
$480,406.00
Summary
Bronchopulmonary dysplasia is a major leading cause of morbidity and mortality in premature babies. There is no cure. We have previously shown that amnion epithelial cells can reduce the extent of lung damage during early stages of lung development. We aim to understand how amnion cells can promote repair by interacting with existing cell types in order to restore normal lung structure and function. The outcomes from this study will help design clinical trials and develop new therapies.
Determining The Genetic Basis Of Skeletal Dysplasias Using Next Generation Sequencing
Funder
National Health and Medical Research Council
Funding Amount
$110,068.00
Summary
Osteoporosis is a common condition in Australia, yet treatment options are still limited. Study of rare genetic bone conditions known collectively as skeletal dysplasias have already led to the development of two new osteoporosis drug treatments. My project aims to identify the causative gene for several skeletal dysplasias, and to determine how these genes are involved in the development and maintenance of bone. This knowledge may then translate into new osteoporosis therapies.
Cell Therapy For Prevention Of Perinatal Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$539,337.00
Summary
Exposure of babies to infection or inflammation before birth is common and is associated with preterm delivery and illness in newborns. The biggest problem for these babies is lung disease due to inflammation of the lungs before birth and/or in response to lung injury after birth. There is no treatment for the underlying inflammation and no way to prevent or treat the lung disease that it causes. This project will investigate a new stem-cell based treatment for lung inflammation that may prevent ....Exposure of babies to infection or inflammation before birth is common and is associated with preterm delivery and illness in newborns. The biggest problem for these babies is lung disease due to inflammation of the lungs before birth and/or in response to lung injury after birth. There is no treatment for the underlying inflammation and no way to prevent or treat the lung disease that it causes. This project will investigate a new stem-cell based treatment for lung inflammation that may prevent life-threatening lung disease in preterm babies.Read moreRead less