Glutamate - Adenosine Interactions And Drug-seeking
Funder
National Health and Medical Research Council
Funding Amount
$558,046.00
Summary
Substance abuse is a significant social and economic burdern upon Australian societies and on societies around the world. Treatment remains problematic due to the multi-layer nature of the disease, difficulties with treatment compliance and less than ideal treatment regimes. The present study aims to improve treatments for alcohol and drug abuse using a polypharmacy or multiple therapy approach, using pre-clinical models to determine the utility of this approach.
Mental Health Literacy And Action To Deal With Mental Heath Problems: A Longitudinal Study Of Young Australians
Funder
National Health and Medical Research Council
Funding Amount
$161,745.00
Summary
Many young people with mental health problems do not get adequate professional help because they lack relevant knowledge. This study will find out what type of knowledge is important for improving appropriate help-seeking by young Australians. Young people who were surveyed two years earlier to assess their mental health knowledge will be followed up to see whether they developed a mental health problem and what action they took to deal with it.
Case-control Study Of Reasons For Presentation Of Nonmelanocytic Skin Cancers At An Advanced Stage.
Funder
National Health and Medical Research Council
Funding Amount
$250,614.00
Summary
There are about four times as many skin cancers treated in Australia each year as all other cancers combined and the vast majority of these are the nonmelanocytic skin cancers (NMSC). While most of these cancers are easily treatable, a proportion of these cancers are not given potentially effective treatment until the cancer has reached an advanced stage. Preliminary results from our pilot studies indicate that at least 50% of patients with NMSC who are treated with radiotherapy and 92% of NMSC ....There are about four times as many skin cancers treated in Australia each year as all other cancers combined and the vast majority of these are the nonmelanocytic skin cancers (NMSC). While most of these cancers are easily treatable, a proportion of these cancers are not given potentially effective treatment until the cancer has reached an advanced stage. Preliminary results from our pilot studies indicate that at least 50% of patients with NMSC who are treated with radiotherapy and 92% of NMSC patients treated with a graft or flap surgical procedure by the dermatologists in Newcastle are so treated because of the extent of disease at the primary site. These advanced stage cancers make an important contribution to the 70,000 admissions to hospital for the treatment of NMSC each year in Australia. The total direct health services cost of treatment of these skin cancers was estimated to be $232,000,000 in 1993-94, which was more than for any other type of cancer. Some 379 people died from nonmelanocytic skin cancer in Australia in 1993 and these were all potentially preventable deaths. The study aims are therefore to: 1. Measure the contributions of delay in seeking treatment and inadequate inital treatment to the need for treatment of skin cancer at an advanced stage. 2. Ascertain the factors that are associated with delay in seeking treatment for skin cancer until it has reached an advanced stage. This study will be the first substantial and population-based study of advanced skin cancer and the factors that underlie it. It will give the first empirical guidance to the design of initiatives to prevent the development of advanced skin cancer, a major area of cost to Australian health services. The study will increase understanding of why some skin cancers are not treated definitively until they reach an advanced stage and guide the development of interventions to reduce the frequency of patients who present with advanced stage skin cancer.Read moreRead less
A Multisite Randomised Controlled Trial Of The Adolescent Cannabis Check-up
Funder
National Health and Medical Research Council
Funding Amount
$211,250.00
Summary
Recent Australian surveys cannabis use is more common than tobacco use among 14-19 year old (24.6% vs. 20.2%). More than 200,000 14-19 year olds have used cannabis in the last month and 7.1% report daily use. The population prevalence of cannabis dependence increases throughout adolescence, with a rate of 30% among those who use cannabis more than five times per year. Although experimentation is a normal part of adolescent development, regular cannabis use by young people exposes them to the neg ....Recent Australian surveys cannabis use is more common than tobacco use among 14-19 year old (24.6% vs. 20.2%). More than 200,000 14-19 year olds have used cannabis in the last month and 7.1% report daily use. The population prevalence of cannabis dependence increases throughout adolescence, with a rate of 30% among those who use cannabis more than five times per year. Although experimentation is a normal part of adolescent development, regular cannabis use by young people exposes them to the negative effects of cannabis at a time of rapid development and transitions in life roles. There have been no studies reported of interventions suitable for adolescents with cannabis problems who are not seeking treatment but are causing great concern for their families, schools and communities. The Adolescent Cannabis Check-up (ACCU) fills this serious gap by providing adolescents with an opportunity to objectively assess their cannabis use and develop strategies for change in a non-judgemental environment. The ACCU is a 2 session intervention: assessment and a follow-up session of personalised feed-back and brief skills-based therapy. Recruitment may be either direct or via a concerned family member. This novel approach provides parents with telephone coaching, and supporting booklets, on techniques to encourage their young person to participate. A feasibility study of 80 families has found more than 50% were able to do so. That study of 55 adolescents found a significant reduction in levels of cannabis use and an abstinence rate of 24.2% 3 months following participation in the ACCU. This project wll involve a multi-site RCT to compare the impact of the ACCU with a delayed treatment control group, on levels of cannabis use, dependence, and cannabis-related problems. This project would fill a gap in treatment service models and involve families in an initiative to assist young people to develop motivation and skills to abstain from problematic cannabis use.Read moreRead less
Phenotypic Characterization Of Chloroquine Resistance In Plasmodia
Funder
National Health and Medical Research Council
Funding Amount
$585,473.00
Summary
In the Asia-Pacific region, vivax malaria is becoming the dominant species of infection. The emergence and spread of chloroquine resistant strains of P. vivax threatens malaria control and elimination efforts. This project aims to elucidate fundamental aspects of chloroquine resistance in non-falciparum malaria and identify novel therapeutic options. We will develop novel tests that will help national malaria control programs to monitor declining activity of standard anti-malarial drugs.