Unravelling The Mechanism Of MHC Class-I Associated Drug Hypersensitivities
Funder
National Health and Medical Research Council
Funding Amount
$566,308.00
Summary
Some drugs cause adverse reactions that are life threatening. We think these reactions are mediated by killer T cells as they are genetically controlled by immune response genes that normally guide immunity to microbes. We will study immune reactions to the drug abacavir, used to treat HIV (AIDS); allopurinol used to prevent gout and carbamazepine, used to treat epilepsy. The study may also help devise better treatments for patients who experience severe forms of these reactions.
Creating and sustaining a strong future for volunteering in Australia. This project seeks to answer the question of how to increase social participation by converting non-volunteers to the benefits of volunteering. In Australia today, communities and governments are increasingly dependent on volunteers to build social capital and deliver an increasing range of services. A world first, this project aims to create new theory by examining three levels of analysis: the micro level of the individual ....Creating and sustaining a strong future for volunteering in Australia. This project seeks to answer the question of how to increase social participation by converting non-volunteers to the benefits of volunteering. In Australia today, communities and governments are increasingly dependent on volunteers to build social capital and deliver an increasing range of services. A world first, this project aims to create new theory by examining three levels of analysis: the micro level of the individual volunteer or non-volunteer; the mezzo level of the volunteer-involving organisation; and the macro level of society. This innovative approach aims to identify, analyse and develop a tool to help organisations build Australia’s civil society and develop policy to create a sustainable volunteer sector into the future.Read moreRead less
DYRK1A As A Novel Target For Glioblastoma Therapies
Funder
National Health and Medical Research Council
Funding Amount
$620,294.00
Summary
Glioblastoma is a form of brain cancer that is currently incurable. We have discovered that switching-off an enzyme called DYRK1A (using ‘DYRK1A inhibitors’) kills glioblastoma cells. This therapeutic advantage is even greater when combined with drugs approved for other cancers. This project will develop new DYRK1A inhibitors and examine a novel combination treatment for glioblastoma patients. This could initiate a novel therapy that could significantly extend patients’ lives.
Developing a national rural volunteering roadmap. This project aims to investigate the challenges affecting rural volunteering in Australia. Conducting a national analysis of volunteering demand and supply, this project expects to generate new interdisciplinary knowledge of the structural, demographic, organisational and personal factors affecting the sustainability of rural volunteering. Expected outcomes of this project include a world-first index of volunteering vulnerabilities and a spatial ....Developing a national rural volunteering roadmap. This project aims to investigate the challenges affecting rural volunteering in Australia. Conducting a national analysis of volunteering demand and supply, this project expects to generate new interdisciplinary knowledge of the structural, demographic, organisational and personal factors affecting the sustainability of rural volunteering. Expected outcomes of this project include a world-first index of volunteering vulnerabilities and a spatial map of volunteering unevenness, leading to the development of an evidence-based National Rural Volunteering Roadmap (2025-2035), which will guide our volunteering peak body partners, governments and rural communities to plan for and support rural volunteering over the longer-term.Read moreRead less
Why is (re)development hot?: Measuring cumulative heat in Australian cities. Incremental (re)development of Australia’s residential areas occurs piecemeal, with varied planning oversight, and results in potentially harmful cumulative warming. This project aims to causally identify the warming effect of residential (re)development and investigate the impact of planning policies that control changes in the built form associated with increased heat exposure. Using large geospatial datasets and a qu ....Why is (re)development hot?: Measuring cumulative heat in Australian cities. Incremental (re)development of Australia’s residential areas occurs piecemeal, with varied planning oversight, and results in potentially harmful cumulative warming. This project aims to causally identify the warming effect of residential (re)development and investigate the impact of planning policies that control changes in the built form associated with increased heat exposure. Using large geospatial datasets and a quasi-experimental research design, warming in Australia’s suburbs over the past decade at the micro (street canyon)- and neighbourhood-scales, will be attributed to (re)development types and ‘fissures’ in policy to inform climate resilient planning. Read moreRead less
Preclinical Development Of A Therapeutic Anticancer Antibody To C-Met
Funder
National Health and Medical Research Council
Funding Amount
$435,530.00
Summary
Many common cancers cannot be effectively treated. A range of these cancers (e.g. gastric and lung cancer) display the molecule c-Met on their cell surface. c-Met promotes tumour growth; therefore, blocking c-Met is a promising strategy for treating these cancers. However, no antibodies or drugs that target c-Met have been licensed. The therapeutics that are being developed to target c-Met all have considerable limitations. Thus, there is an opportunity to develop a 'best-in-class' therapeutic.
The Macroderma initiative: conserving ghost bats and informing development. This project aims to improve methods for capturing biological information required for environmental assessments of highly mobile species and enable strategic environmental planning in Northern Australia. Using Australia’s iconic ghost bat as a focus, the project will test and apply emerging technologies to obtain key information on a species’ population status and its critical resources to inform assessments of ecologic ....The Macroderma initiative: conserving ghost bats and informing development. This project aims to improve methods for capturing biological information required for environmental assessments of highly mobile species and enable strategic environmental planning in Northern Australia. Using Australia’s iconic ghost bat as a focus, the project will test and apply emerging technologies to obtain key information on a species’ population status and its critical resources to inform assessments of ecological impacts of industry development. Important benefits of the project include information and tools for streamlining development approvals and accurately assessing risks to threatened species to improve outcomes for both our economy and our natural environment.Read moreRead less
Designing Human Resource Practices that Promote the Retention of Volunteers. This project aims to examine the effects of human resources practices on the attraction and retention of high-quality volunteers. Volunteers provide essential health and educational services to the Australian population, which makes it important for non-profit organisations to develop effective human resource practices that attract and retain the best people. However, non-profit organisations often struggle to attract a ....Designing Human Resource Practices that Promote the Retention of Volunteers. This project aims to examine the effects of human resources practices on the attraction and retention of high-quality volunteers. Volunteers provide essential health and educational services to the Australian population, which makes it important for non-profit organisations to develop effective human resource practices that attract and retain the best people. However, non-profit organisations often struggle to attract and retain a sufficient number of volunteers. This project will examine the effects of three human resource practices on the thriving and organisational attachment of volunteers using theories of motivation and retention. This knowledge is intended to help governments and non-profit organisations improve on policies and procedures to manage Australia’s volunteer workforce sustainably.Read moreRead less
On-line monitoring of cyanobacteria to predict coagulant doses and powdered activated carbon application in water treatment. Cyanobacteria, more commonly known as blue-green algae, can impact water quality by releasing toxins that can be harmful to human health and imparting unpleasant taste and odours to the water. This project will support the water industry in managing these risks by providing a rapid, on-line tool to assist in their removal during water treatment.
Carbon nanotube fluidic channels for desalination - interplay of nanoscale confinement and electrostatics. Tiny tubes of carbon, ten thousand times smaller than human hair, allow water to pass through at extraordinary speed. This project aims to understand and improve their salt rejection properties using comprehensive experimental and theoretical approaches. This will provide the impetus and knowledge for developing advanced membranes for desalination