Centre Of Research Excellence In Medicines Intelligence
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
The NHMRC Centre of Research Excellence in Medicines Intelligence is a co-ordinated research program that will accelerate the development and translation of evidence on prescribed medicines use and outcomes for regulators and payers. The CRE is perfectly placed to embrace the national ‘call to action’ from the Health Minister's recent announcement to establish Quality Use of Medicine Safety as a National Health Priority.
Does mate choice play a role in the fertilization ecology of free-spawners? Botanists have long recognised the consequences of differential compatibility between mates for breeding programs and agriculture. In important aquaculture species such as abalone and sea-urchins, similar variation in mate compatibility has been observed but current theory struggles to explain this variation and its consequences. I have identified a new explanation for this variation and will test this explanation using ....Does mate choice play a role in the fertilization ecology of free-spawners? Botanists have long recognised the consequences of differential compatibility between mates for breeding programs and agriculture. In important aquaculture species such as abalone and sea-urchins, similar variation in mate compatibility has been observed but current theory struggles to explain this variation and its consequences. I have identified a new explanation for this variation and will test this explanation using a marine invertebrate that is a model system for study around the world. A positive result offers promise of explaining how females 'select' mates in free-spawning species and explaining the consequence of this mate selection.Read moreRead less
Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.
Re-EValuating The Inhibition Of Stress Erosions (REVISE): Gastrointestinal Bleeding Prophylaxis In ICU
Funder
National Health and Medical Research Council
Funding Amount
$2,955,164.00
Summary
Around 50,000 patients in Australian Intensive Care Units receive a drug called pantoprazole each year with the aim of preventing bleeding from the gut. Recent research suggests this practice is ineffective and may harm patients by increasing their risk of serious infections. We will perform a definitive study to determine whether the widespread use of pantoprazole is beneficial or harmful.