Rationally Designed Targeted Core Shell Nano-Construct For Improved Anticancer Effects And Enhanced Bone Fracture Healing In Breast Cancers Metastasised To Bone
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
The main objective of the project is to develop and evaluate a single therapeutic system comprising chemotherapeutic as well as bone fracture healing agent, which will overcome the drawbacks of the conventional treatment for skeletal bone metastasised breast cancers. This therapeutic system will specifically accumulates in the tumour sites and release the chemotherapeutic enabling anticancer effects, followed by the slow release of bone fracture healing agent results in healing of fractures.
Advancing Nanomedicine Through Particle Technology
Funder
National Health and Medical Research Council
Funding Amount
$876,005.00
Summary
This proposal will support the development of advanced particle systems to improve the delivery of medicines in neurological diseases, HIV, diabetes and cancer. It will provide important insights for particle-based therapeutic delivery that are expected to underpin progress on nanotechnology in the areas of biology and medicine. These developments in nanotechnology-enabled medicines towards commercialisation will ultimately improve the health and quality of life of Australians.
In this fellowship I will develop methods to improve the way drugs are delivered through the use of nanotechnology. Nanoparticles can be used to protect delicate drugs from degrading, and to make sure drugs are delivered where they are required. This helps to lower side effects and improve efficacy of a range of drugs. I lead a multi-disciplinary research team dedicated to understanding of how nanoparticles interact with biological systems, so we can engineer better drug delivery systems.
Improving Therapeutic Delivery By Understanding Nanoparticle Interactions With Cells
Funder
National Health and Medical Research Council
Funding Amount
$553,152.00
Summary
Nanotechnology has the potential to transform the way we treat many diseases. This project will investigate how nanoengineered particles can be used to improve the effectiveness of vaccines. Nanoparticles can protect the delicate vaccine cargo from degradation, and will be targeted specifically to the cells in the body that most effectively induce the maximum theraputic response. This study will improve our understanding of how nanovaccines work and develop new ways of delivering vaccines.
Platform Nanotechnologies For Oral Delivery Of Drugs, Therapeutic Protein And Peptide Delivery
Funder
National Health and Medical Research Council
Funding Amount
$437,034.00
Summary
The development of reliable oral delivery systems for problem drugs and biologics is one of the biggest challenges faced by the pharmaceutical industry in recent times. In order to tackle these challenges, I have developed programmable nanoparticles capable of efficiently deliver wide range of drugs including large peptides and proteins orally.
Next Generation Imaging To Bridge The Knowledge Gap In Nanomedicine Delivery
Funder
National Health and Medical Research Council
Funding Amount
$483,402.00
Summary
Nanomedicines are generally touted as the next generation in therapeutics. However, despite some landmark successes, their translation into clinical use is limited. This is mainly a result of poor understanding of how they behave under physiological conditions. To address this issue and improve translation, this fellowship aims to develop predictive models of how nanomedicines interact with biological systems, then validate the nanomedicines in dog models of cancer that mimic the human disease.
A Targeted Approach To Age Related Disease: Nanomedicines And The Liver Sinusoidal Endothelium
Funder
National Health and Medical Research Council
Funding Amount
$560,241.00
Summary
Cells that line the liver blood vessels undergo predictable and distinct changes with age that increase the risk of developing diseases of older age like Diabetes and Cardiovascular Disease. We can now selectively target the changes in the liver cells with nanomedicines to prevent and treat these changes. The implications of this study are vast – a new therapy for the prevention and treatment of age-related cardiovascular disease and diabetes.
The Use Of Gene-Silencing Nanodrugs To Inhibit Lung Cancer Growth
Funder
National Health and Medical Research Council
Funding Amount
$452,950.00
Summary
Lung cancer accounts for the most cancer deaths worldwide. This research proposal will use state-of-the-art nanomedicines designed to penetrate lung tumours and suppress a gene which drives cancer growth and resistance to chemotherapy drugs. Our results could underpin new approaches that revolutionise more effective and less toxic treatments for a highly lethal malignancy.
Next-generation Glioblastoma Multiforme Therapies Based On Multistage Delivery Nanovectors
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Nanomedicine provides novel therapies with enhanced treatment success and reduced side effects, which improve the patient’s quality of life. Drug delivery systems that are able to treat highly drug-resistant tumours such as glioblastoma multiforme (GBM) are a key target for nanomedicine-based therapies. We will investigate a new GBM treatment by developing a multistage delivery nanovector to selectively carry and release a combination of chemical and physical therapeutics.
Can Nanoparticles Give An Old Iron Chelator A New Life? — Development Of Targeted Polymeric Nanoparticles With Long Half-lives To Treat Iron Overload Diseases
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Iron loading disorders (such as thalassaemia) represent an important class of human disease. As part of the treatment for these diseases, the iron needs to be removed and this is often done using iron-binding drugs known as iron chelators. Current chelators are not ideal due to side effects or onerous delivery methods. The goal of this project is to use nanotechnology to develop more effective ways of delivering chelators to improve their effectiveness and reduce toxicity.