Fundamental study of fracture-controlled compensation grouting for ground movement. This project aims to investigate the fundamentals of fracture-controlled compensation grouting in various types of soil, so as to optimise the compensation efficiency and to minimise the risk of collapse of nearby structures. This will result in the minimisation of ground movements induced by underground excavations, which pose a major threat to existing infrastructure and communities worldwide. Small-scale labor ....Fundamental study of fracture-controlled compensation grouting for ground movement. This project aims to investigate the fundamentals of fracture-controlled compensation grouting in various types of soil, so as to optimise the compensation efficiency and to minimise the risk of collapse of nearby structures. This will result in the minimisation of ground movements induced by underground excavations, which pose a major threat to existing infrastructure and communities worldwide. Small-scale laboratory experiments, centrifuge tests and numerical analyses will be conducted to develop an effective and economical grouting method that will provide a valuable design tool for engineers.Read moreRead less
Generative Materialism: advancing design of the digital and physical. This interdisciplinary project aims to open the way for the next generation of manufacturing technologies by linking advanced computer science with the creative arts. Using innovative techniques that combine generative systems, advanced digital fabrication and the creative needs of modern design, the project seeks to boost human creativity by intelligently connecting the digital and physical processes of generative systems. Th ....Generative Materialism: advancing design of the digital and physical. This interdisciplinary project aims to open the way for the next generation of manufacturing technologies by linking advanced computer science with the creative arts. Using innovative techniques that combine generative systems, advanced digital fabrication and the creative needs of modern design, the project seeks to boost human creativity by intelligently connecting the digital and physical processes of generative systems. The outcomes will help build the next generation of digital arts software systems that assist creative and industry professionals to excel, promoting higher productivity and greater creativity vital to Australia's future creative industries. This will provide benefits such as the creation of breakthrough systems for the creative industries that elevate the role of computational generation and on-demand manufacturing in contemporary design, production and creative practice.Read moreRead less
Adaptive structural systems for high-performance buildings. This project aims to develop adaptive structural systems for high-performance buildings. A new theoretical platform will be instrumental in the development of building technologies such as adaptive shading and ventilation components. In a reversal of the conventional design avoidance of structural phenomena such as lateral and flexural-torsional buckling, these phenomena will be exploited to achieve functional forms for shading componen ....Adaptive structural systems for high-performance buildings. This project aims to develop adaptive structural systems for high-performance buildings. A new theoretical platform will be instrumental in the development of building technologies such as adaptive shading and ventilation components. In a reversal of the conventional design avoidance of structural phenomena such as lateral and flexural-torsional buckling, these phenomena will be exploited to achieve functional forms for shading components. Thin-metal ventilation ducts will be embedded within structural components to produce optimised ventilation strategies and to increase thermal mass, while accounting for their structural contribution.Read moreRead less
Modelling and simulation of complex granular flows. Granular flows are of crucial importance in a wide range of problems related to civil infrastructure. These include landslides and similar catastrophic events, often leading to loss of life and property. The project aims to develop new methods for accurate prediction of such events thus allowing for the formulation of efficient mitigation strategies.
Theoretical modelling and design of safe covalent anti-cancer drugs. Covalent drugs are a new class of drugs with outstanding potential in cancer therapy. Detailed computer modelling studies will be performed to determine how these drugs interact with an important target in cancer therapy, the epithelial growth factor receptor, and thereby aid the development of new cancer treatments.
Bioactive Peptides as Pharmacological Tools and Novel Drug Leads. Bioactive peptides are produced by all organisms and play numerous critical physiological roles, including in cellular communication, host defence and capture of prey. Peptides have huge potential as tools for studying roles of signalling pathways and as novel drugs due to their high affinity and selectivity for various therapeutically relevant targets. However their use has been limited by poor in vivo stability. This project is ....Bioactive Peptides as Pharmacological Tools and Novel Drug Leads. Bioactive peptides are produced by all organisms and play numerous critical physiological roles, including in cellular communication, host defence and capture of prey. Peptides have huge potential as tools for studying roles of signalling pathways and as novel drugs due to their high affinity and selectivity for various therapeutically relevant targets. However their use has been limited by poor in vivo stability. This project is focused on studying structural features of a range of peptides and their contributions to both activity and to resistance against degradation, with the aim to develop stabilised bioactive peptide sequences for in vivo applications, allowing the full potential of peptides as drugs to be realised.Read moreRead less
Variational multiscale modelling of granular materials. Granular materials play an important role in a wide-range of problems related to physical infrastructure. These include landslides and similar catastrophic events often leading to loss of life and property. This project will aim to develop new methods for adequate simulation of granular flows to allow formulation of efficient risk mitigation strategies.
Urban spaces and active ageing: understanding person-environment interactions to inform activity-friendly community design. The proportion of older adults in urban areas is rapidly growing, leading to increases in health-care costs that are associated with chronic diseases. This can be offset by creating urban environments that support an active lifestyle across mid-to-late adulthood. How urban community designs shape the physical activity of this understudied age group is unclear. Using a suite ....Urban spaces and active ageing: understanding person-environment interactions to inform activity-friendly community design. The proportion of older adults in urban areas is rapidly growing, leading to increases in health-care costs that are associated with chronic diseases. This can be offset by creating urban environments that support an active lifestyle across mid-to-late adulthood. How urban community designs shape the physical activity of this understudied age group is unclear. Using a suite of national and international epidemiological studies, This project aims to identify the optimal mix and spatial distribution of destinations (facilities and places to visit) for active ageing, while taking into account factors that define one’s ability and willingness to visit these destinations. This will inform public policy and activity-friendly community design.Read moreRead less
Electronic coupling and nanoscale engineering of two-dimensional nanojunctions. This project aims to improve the design of photovoltaic, energy storage, and nanocatalytic devices by using quantum-size tuning, orientation control, strain engineering, and surface modification to manipulate the electronic coupling and charge transfer of two-dimensional nanojunctions. The limitations of and potential environmental damage from fossil-fuel-based energy resources have increased interest in renewable en ....Electronic coupling and nanoscale engineering of two-dimensional nanojunctions. This project aims to improve the design of photovoltaic, energy storage, and nanocatalytic devices by using quantum-size tuning, orientation control, strain engineering, and surface modification to manipulate the electronic coupling and charge transfer of two-dimensional nanojunctions. The limitations of and potential environmental damage from fossil-fuel-based energy resources have increased interest in renewable energy research. The expected outcomes are electron-scale understanding of the tuneable functionalisation of two-dimensional nanojunctions and the design of low-cost and high-efficiency renewable energy devices.Read moreRead less
Platform technologies for multifunctional nanocarrier systems. Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microflu ....Platform technologies for multifunctional nanocarrier systems. Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microfluidic platform technology for reproducibly producing targeted polymer nanocarriers having systematically varied properties, a dual-templating method for making targeted silica nanocapsules and new design of in vivo-mimicking 'Tissue Chips' for screening and evaluating the nanocarriers.Read moreRead less