A Long-Lasting Oral Drug Delivery System Using Spiky Silica Nanoparticles
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
This project aims to develop a novel silica nanoparticle-based delivery system for long-lasting oral drug delivery. The particles will be engineered with a spiky morphology that will increase adhesion to the gastrointestinal tract enabling sustained drug release for days or even weeks. Longer lasting oral drug formulations would make it much easier for patients to adhere to the treatment schedules required in chronic diseases like HIV and increase the effectiveness of therapy.
The Role Of Pharmacotherapy In Prevention Of Relapse In Alcohol Dependence
Funder
National Health and Medical Research Council
Funding Amount
$422,310.00
Summary
The physical, psychological and social consequences of alcohol abuse remain a critical health problem. Every year in Australia, excessive consumption is responsible for 3,000-6,000 deaths and costs the community $6 billion. Approximately 15% of Australians abuse alcohol and 5% of men and 3% of women are alcohol dependent (addicted to alcohol). Young men are particularly affected, with 10% of all men aged 18-35 dependent on alcohol. Better treatment for alcohol dependence is urgently needed. Less ....The physical, psychological and social consequences of alcohol abuse remain a critical health problem. Every year in Australia, excessive consumption is responsible for 3,000-6,000 deaths and costs the community $6 billion. Approximately 15% of Australians abuse alcohol and 5% of men and 3% of women are alcohol dependent (addicted to alcohol). Young men are particularly affected, with 10% of all men aged 18-35 dependent on alcohol. Better treatment for alcohol dependence is urgently needed. Less severe forms of alcohol abuse frequently respond to brief screening and intervention programs. Treatment of alcohol dependence remains unsatisfactory. Most treatments lead to abstinence in only 1-3, and approximately 50% of these will relapse within 3 months of completing treatment. Two drugs (naltrexone and acamprosate) appear to interfere with the effects of alcohol on the brain that promote addiction. There is evidence that both drugs are beneficial in the treatment of alcohol dependence and both are now available in Australia. At present, no data have been reported comparing the effectiveness of these two drugs. The proposed project will compare naltrexone and acamprosate in a large carefully performed study. The study will help determine which subjects are likely to benefit from one or other of these agents. Compliance is a major problem with many medications, but is a particular problem with medications for substance abuse. The second aim of this study is to test a novel intervention to increase compliance with medications for alcohol dependent subjects. This intervention comprises 'compliance therapy', which resembles a short training course, a medication alarm, and an assertive reminder program for scheduled medical appointments. The present study will be the first to apply this type of therapy to subjects with alcohol dependence.Read moreRead less
In Vitro And In Vivo Assessment Of The Funhaler -an Innovative Therapeutic Device For Children
Funder
National Health and Medical Research Council
Funding Amount
$472,750.00
Summary
Aerosol therapy is the most effective form of treatment for children with respiratory diseases such as asthma. While optimising aerosol delivery systems has an important role in increasing the efficacy of asthma therapy, ensuring patient compliance is often the most difficult part of the clinician's role, particularly in the paediatric age group. An innovative small volume spacer device (Funhaler) developed by a West Australian company (InfaMed, Ltd) may help overcome this problem. The Funhaler ....Aerosol therapy is the most effective form of treatment for children with respiratory diseases such as asthma. While optimising aerosol delivery systems has an important role in increasing the efficacy of asthma therapy, ensuring patient compliance is often the most difficult part of the clinician's role, particularly in the paediatric age group. An innovative small volume spacer device (Funhaler) developed by a West Australian company (InfaMed, Ltd) may help overcome this problem. The Funhaler incorporates a spinning toy attached to the outside of the spacer. The toy is activated when the patient breathes through the spacer. The device has been designed to encourage children to co-operate when their asthma therapy is being delivered. The Funhaler is currently in the late development stage. We propose, firstly, to carry out in vitro assessments of drug delivery from the Funhaler compared to the two most widely available small volume spacers: the Aerochamber Plus (Trudell, Canada) and the Breath-A-Tech (Scott-Dibben, Australia). These assessments will be carried out to meet the standards of regulatory bodies worldwide (including the FDA). Secondly, we propose to perform extensive in vivo studie: filter studies to assess drug delivery to the patient; deposition studies to measure drug deposition in the lungs; and a pilot clinical trial to assess the efficacy of the device during medium to long-term use in children aged 2-8 years.Read moreRead less
This project will unleash the potential of peptide drugs by overcoming their final barrier to widespread use, their synthesis. Plants naturally produce ultra-stable cyclic peptides. We will co-opt their machinery to produce in seeds, two drug leads that have potential as treatments for prostate cancer and chronic neuropathic pain. As an �organic� drug source, seeds have the potential to improve patient compliance and low-tech production systems will allow technology transfer to third-world natio ....This project will unleash the potential of peptide drugs by overcoming their final barrier to widespread use, their synthesis. Plants naturally produce ultra-stable cyclic peptides. We will co-opt their machinery to produce in seeds, two drug leads that have potential as treatments for prostate cancer and chronic neuropathic pain. As an �organic� drug source, seeds have the potential to improve patient compliance and low-tech production systems will allow technology transfer to third-world nations.Read moreRead less
Optimising The Efficiency Of Enforcement In Commercial Fisheries
Funder
Fisheries Research and Development Corporation
Funding Amount
$233,474.55
Summary
The cost of enforcement in most fisheries is substantial. There has been little research on the effectiveness of enforcement measures or the investigation of alternate enforcement strategies. An understanding of the fisher’s perception of the enforcement program, particularly the perceived level of inspections, and how they will respond to changes in enforcement is required to more effectively and efficiently maintain compliance with the regulations.
Similarly the relationship between ....The cost of enforcement in most fisheries is substantial. There has been little research on the effectiveness of enforcement measures or the investigation of alternate enforcement strategies. An understanding of the fisher’s perception of the enforcement program, particularly the perceived level of inspections, and how they will respond to changes in enforcement is required to more effectively and efficiently maintain compliance with the regulations.
Similarly the relationship between the extent of enforcement effort and the level of compliance is not understood for most fisheries. If the rate of compliance is not overly sensitive to the amount or type of enforcement it may be possible to reduce some elements of the enforcement effort and cost while maintaining an acceptable level of compliance. On the other hand if the rate of compliance is highly sensitive to the amount of enforcement effort it will be possible to determine the amount of effort required to obtain the required level of compliance.
The true nature and extent of non-compliance is required to better direct enforcement effort. Spatial and temporal patterns of non-compliance need to be investigated. A better understanding of the motivation for non-compliance, whether the incentive is financial or otherwise, will be gained by comparing expected gains against the likely penalties and probability of detection. This will enable the effectiveness of penalties as a deterrent to be assessed. This information is needed in a form that will enable managers responsible for enforcement activities to explore the effect of the location, timing and type of enforcement activity on the level of compliance. Objectives: 1. Estimate the level of non-compliance in the Western Australian rock lobster industry. 2. Determine factors such as seasonal, regional and factory, which may affect the level of non-compliance in order to better target the timing of enforcement effort. 3. Develop relationships between enforcement and compliance with the regulations to enable an assessment of increasing or decreasing the level of enforcement on the level of compliance. 4. Determine the reasons and motivations for the non-compliance of commercial fishers with the regulations in terms of the expected gains versus the probability of detection. 5. Ascertain the perceptions of the fishing regulations and enforcement measures including the perceived probability of detection for commercial fishers. 6. Ascertain whether commercial fishers are aware of the full extent and frequency of inspections. Read moreRead less
Establishment Of A Fish Marketing Technical Advisory Service To Fishermen, Processors And Merchants
Funder
Fisheries Research and Development Corporation
Summary
Objectives: 1. Educate fishermen & co-ops on improving quality of catches through better handling methods. 2. Educate processors, wholesalers & retailers on care, storage & presentation of fish & crustaceans. 3. Print information leaflets, posters on handling; promote Aust spp, especially new
Application Of Molecular Genetics To The Australian Abalone Fisheries: Forensic Protocols For Species Identification And Blacklip Stock Structure
Funder
Fisheries Research and Development Corporation
Funding Amount
$353,888.00
Summary
The state of molecular genetic technology in abalone is underdeveloped and in need of some basic research to develop molecular protocols that can be applied to various management and compliance issues; microsatellite markers are likely to have the most utility, and other abalone fisheries will benefit from Australian research (Sweijd 1997 - External review FRDC 98/126).
Abalone populations elsewhere in the world have crashed catastrophically. Australian abalone resources are in a relat ....The state of molecular genetic technology in abalone is underdeveloped and in need of some basic research to develop molecular protocols that can be applied to various management and compliance issues; microsatellite markers are likely to have the most utility, and other abalone fisheries will benefit from Australian research (Sweijd 1997 - External review FRDC 98/126).
Abalone populations elsewhere in the world have crashed catastrophically. Australian abalone resources are in a relatively good condition, but are under heavy pressure from many external factors, including poaching, that could cause irreversible damage. In addition, some sections of the industry are excited by the potential of translocation or reseeding for stock enhancement, but without fully understanding the genetic variability in a population this represents a high conservation risk. Understanding genetic variation in abalone at both the species and stock level is vital to the long-term sustainability of these valuable fisheries, as well as for genetic conservation.
Compliance is not only a major issue in the draft 1998 review of wild abalone R&D needs in Australia, but is also an international issue. There are currently no forensic tools available in Australia to assist authorities identify abalone products and force compliance.
The application of molecular genetics in this study will provide managers with: • forensic tests for species identification • estimation of rates of gene flow between selected locations (i.e. stock identification).
Stock identification is needed not only for managing the commercial and recreational catch, but also for assessing the risks of translocation and reseeding projects, and land-based or sea-based aquaculture industries.
This study will build on a pilot project that developed the basis for an abalone forensic protocol, and will also provide a comprehensive assessment of the use of microsatellite markers for abalone stock identification. These goals are of both national and international interest. Objectives: 1. To refine, and where necessary establish, abalone species identification protocols to forensic standards suitable for required fisheries compliance. 2. To define the stock structure of blacklip abalone (Haliotis rubra) around Tasmania, using polymorphic nuclear DNA microsatellite markers. 3. To determine a suitable sampling and analysis regime for other temperate Australian abalone fisheries. 4. To determine the possible effects of harvesting on the genetic conservation of the blacklip abalone (H. rubra), by comparing the allozyme variation of two areas of the Tasmanian fishery with results obtained from the same areas in the late 1980s. Read moreRead less