Cognitive Phenotyping And Personalised Treatment For Methamphetamine Addiction
Funder
National Health and Medical Research Council
Funding Amount
$483,402.00
Summary
Prevention and treatment of addiction to stimulants such as methamphetamine is imperative for community health and safety. This fellowship will enable me to apply my expertise in impulsivity and addiction to identify people at risk of increasing methamphetamine use and to develop and evaluate cognitive training therapies that will empower people with methamphetamine related problems to control their drug use. Outcomes include a risk identification and triage tool and three novel therapies.
Translating Neuroscience Into Treatments And Public Health Policies For Addictive Behaviours
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Advances from neuroscience promise to revolutionise our ability to treat and prevent addictive disorders such as gambling, overeating and drug addiction. These developments may also have unexpected clinical consequences, undermine individuals’ belief in their control over their behaviour or increase stigma and discrimination. This project will develop clinical guidelines and public health policy recommendations to ensure that we realise the benefits of neuroscience while minimising social harms.
Extinguishing Fearful And Addictive Brain During Adolescence
Funder
National Health and Medical Research Council
Funding Amount
$428,437.00
Summary
Exposure therapies rely on the decrease in emotions to previous triggers due to the exposure to those triggers without an emotional event in a safe environment. Adolescence marks a period of maturation that is particularly resistant to such therapies, due to the imbalance of different receptors in their prefrontal cortex. We will redress such chemical imbalance by using existing clinically-approved drugs, and facilitate behavioural therapies to treat adolescent anxiety and substance abuse.
Reducing The Burden Of Disease And Inequity Related To Preventable Health Risk Behaviours
Funder
National Health and Medical Research Council
Funding Amount
$466,492.00
Summary
Smoking is Australia’s top ranked cause of disease. It is also one of the main causes of inequalities in health outcomes. My research aims to test strategies to reducing smoking and improve other lifestyle behaviours, like diet and exercise, alcohol, and sun protection, in the most disadvantaged groups. To achieve this goal, I have partnered with health and non-health care services. I expect my research to reduce the gap in health behaviours and health outcomes between more and less advantaged s ....Smoking is Australia’s top ranked cause of disease. It is also one of the main causes of inequalities in health outcomes. My research aims to test strategies to reducing smoking and improve other lifestyle behaviours, like diet and exercise, alcohol, and sun protection, in the most disadvantaged groups. To achieve this goal, I have partnered with health and non-health care services. I expect my research to reduce the gap in health behaviours and health outcomes between more and less advantaged sectors of society.Read moreRead less
Dependent drug use is associated with a range of physical and mental health problems. However the process by which drug-related changes to the human brain influence behaviours important to remaining abstinent is poorly understood. The current proposal investigates the neural and behavioural effects of drug dependence on cognitive control - responsible for impulse control and decision making - previously implicated in drug dependence.
REDUCING HARMS FROM SUBSTANCE MISUSE IN REMOTE INDIGENOUS COMMUNITIES REQUIRES INTERVENTIONS DELIVERED AS PROMISED WITH MEASURABLE IMPACTS?
Funder
National Health and Medical Research Council
Funding Amount
$439,920.00
Summary
We cannot accurately estimate the occurrence of many diseases and risk factors for remote Indigenous communities where more of the ‘health gap’ is suffered. Interventions targeting substance misuse risk factors have not yet produced the community- and individual-level impacts they were designed to bring about. In this Fellowship, I will improve evaluation methods and measures to produce credible evidence for assessing program implementation and effectiveness in remote communities.
The Hunt For New-generation Lipopeptide Antibiotics Targeting Gram-negative ‘Superbugs’
Funder
National Health and Medical Research Council
Funding Amount
$473,477.00
Summary
The dry antibiotic discovery and development pipeline, together with the increasing incidence of bacterial resistance in the clinic has been dubbed ‘the perfect storm’. This project involves the design, synthesis and preclinical evaluation of a new generation of polymyxin-like lipopeptides that have low nephrotoxicity and specifically target polymyxin-resistant Gram-negative ‘superbugs’.