Stimulant laxatives are widely used and usually very effective in the short term, but how they work is very poorly understood. Our recent work has shown that they selectively excite sensory pathways from the colon which then trigger defaecation. This points to an undiscovered mechanism that potently affects colonic sensation and motility. This is likely to be a target for new treatments for other colonic disorders such as Irritable bowel syndrome and faecal incontinence.
Predicting Drug-drug Interactions Due To Tyrosine Kinase Inhibitors: Inhibition Of Drug Metabolising Enzymes And Transporters
Funder
National Health and Medical Research Council
Funding Amount
$535,495.00
Summary
Tyrosine kinase inhibitors (TKIs) are a new class of anticancer agents. Cancer patients typically receive multiple drugs, for the treatment of cancer and other diseases, increasing the probability of interactions between coadministered drugs. Despite the widespread use of TKIs, their potential to cause drug interactions is poorly understood. Using novel in vitro approaches, this project will identify drug interactions precipitated by TKIs thereby improving drug efficacy and patient safety.
Looking Forward - Moving Forward Project: Transforming Systems To Improve Mental Health And Drug And Alcohol Outcomes For Aboriginal Peoples
Funder
National Health and Medical Research Council
Funding Amount
$1,304,508.00
Summary
Despite the clear need for support, Aboriginal people do not access mental health and drug and alcohol services at a level that corresponds with their need. We need to know how services can respond appropriately to this high-risk group of people. This project brings together Perth-based services, researchers and local Aboriginal Elders to implement and evaluate a framework for organisational change that will transform the way in which services respond to Aboriginal people.
Development And Evaluation Of Novel Anti-inflammatory Products Derived From An Indigenous Medicinal Plant
Funder
National Health and Medical Research Council
Funding Amount
$276,598.00
Summary
This collaborative project between researchers at the University of South Australia and Indigenous traditional owners from Northern Kaanju homelands (Cape York Peninsula, Qld) will develop and evaluate products derived from the Northern Kaanju medicinal plant Dodonaea polyandra. Extracts of the plant and novel compounds isolated from it have anti-inflammatory activity. These have the potential to be used in inflammatory diseases such as dermatitis, arthritis and inflammatory bowel disease.
A Novel Metabolic Role For UDP Glycosyltransferase 8 (UGT8)
Funder
National Health and Medical Research Council
Funding Amount
$419,144.00
Summary
The UDP glycosyltransferases (UGTs) are a family of enzymes that remove drugs and toxins from the human body as well as control levels of naturally produced molecules such as bile acids and hormones. We found that a new member of this family called UGT8 processes bile acids in the kidney and intestine and can affect how bile acids act to regulate metabolism. Our studies uncover new roles for bile acids in liver, kidney and gut health and in metabolic disorders such as diabetes and obesity.
Structure And Function Of Antimicrobial Therapies And Their Interaction With Upper Respiratory Biofilms
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
Bacterial infections of the upper respiratory tract are a major public health problem affecting millions of Australians. Commonly prescribed antibiotics are often not able to eradicate all bacteria as the bacteria often reside in a protective, self-produced gel-like matrix known as biofilm. This Fellowship aims to unravel the interaction of modern anti-infective therapeutics with the biofilm for the development of the next generation of safe and efficacious anti-biofilm strategies.
The emotional construction of self representation. This project develops and defends the novel idea that self representation is an artefact of emotional processing. The account will involve case studies of psychiatric disorder characterised by developmental or acquired problems of self representation such as depersonalisation disorder and personality disorders.
The ownership of minds. This project aims to research the awareness of a conscious state as the subject's own. This is at the heart of a perennial debate about consciousness: whether we are aware of our conscious states as our own, or are merely aware of their occurrence. The project will collaborate internationally and across disciplines and institutions to develop a conceptual distinction between two components of consciousness. It will also provide an analysis of the nature of three mental di ....The ownership of minds. This project aims to research the awareness of a conscious state as the subject's own. This is at the heart of a perennial debate about consciousness: whether we are aware of our conscious states as our own, or are merely aware of their occurrence. The project will collaborate internationally and across disciplines and institutions to develop a conceptual distinction between two components of consciousness. It will also provide an analysis of the nature of three mental disorders in which the two components seem to come apart. These outcomes are expected to constitute a significant innovation in the study of consciousness and, more generally, in the philosophy of mind.Read moreRead less