Identification And Characterisation Of Novel Genetic Alterations In High Risk Acute Lymphoblastic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$315,336.00
Summary
Acute lymphoblastic leukaemia (ALL) remains the leading cause of cancer-related death in children and young adults. The goal of this research is to identify genetic abnormalities that contribute to treatment failure in high-risk ALL. In addition to providing insights into the biologic basis of ALL, this work has the potential to result in new diagnostic tests, predict response to chemotherapy, and identify new strategies to improve the treatment outcome for ALL patients.
Pharmacological Investigation Of The Glucagon-Like Peptide-1 Receptor (GLP-1R)
Funder
National Health and Medical Research Council
Funding Amount
$367,948.00
Summary
Family B G protein-coupled receptors represent key therapeutic targets for many conditions, including metabolic, bone, growth and neuronal disorders. However, poor mechanistic understanding of this receptor family impacts on their clinical value. Consequently, this research is aimed at gaining a more comprehensive understanding of the structure and function of the family B glucagon-like peptide-1 receptor through use of new and novel pharmacological techniques.
Linking Estrogens, Prostatitis And Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$291,309.00
Summary
Prostatitis is very common and a significant health issue that affects men from their 20's. Estrogens promote inflammation and inflammation is associated with the development of cancer. If this study links estrogens, prostatitis and prostate cancer, we can provide better treatment for prostatitis, thus preventing progression to prostate cancer
Central Ghrelin Regulates Peripheral Glucose Metabolism
Funder
National Health and Medical Research Council
Funding Amount
$339,938.00
Summary
Recent evidence shows ghrelin is a key anti-starvation hormone that increases glucose production in order to maintain appropriate blood glucose concentrations. How ghrelin acts in the brain to control blood glucose concentrations remains unknown and will be the focus of this project. This project is relevant to disorders such as anorexia nervosa and will help us understand blood glucose regulation during conditions of food scarcity.
A Novel Mechanism Involved In The Regulation Of MTOR Signaling By Insulin In Adipocytes
Funder
National Health and Medical Research Council
Funding Amount
$224,324.00
Summary
I am a cell biologist with a major interest in insulin action and diabetes. I aim to determine the role of insulin as a nutrient sensor in fat cells. This is very important as it is becoming evident that fat cells somehow sense the amount of nutrients in the circulation and then relaying this information to other tissues including the brain. This system may play an important role in the development of obesity. However, the molecular details of the nutrient sensor remain poorly defined.
Thyroid-sympathoadrenal Regulation Of Human Brown Fat
Funder
National Health and Medical Research Council
Funding Amount
$447,141.00
Summary
This project aims to determine how hormones influence the growth and activity of brown fat in humans. Majority of fat cells in the body are white fat cells, which store fat, and cause obesity when in excess. Brown fat cells function like generators. They burn fat and release energy as heat. Humans with lots of brown fat are lean. What controls brown fat activity is currently unknown in humans. This project investigates how hormones influence brown fat activity and may shed light on the therapeut ....This project aims to determine how hormones influence the growth and activity of brown fat in humans. Majority of fat cells in the body are white fat cells, which store fat, and cause obesity when in excess. Brown fat cells function like generators. They burn fat and release energy as heat. Humans with lots of brown fat are lean. What controls brown fat activity is currently unknown in humans. This project investigates how hormones influence brown fat activity and may shed light on the therapeutic potential of brown fat in obesity treatment.Read moreRead less