Driving Change: Using Emergency Department Data To Reduce Alcohol-related Harm
Funder
National Health and Medical Research Council
Funding Amount
$1,468,026.00
Summary
The proposed project is a system change within partner emergency departments, providing them the information and tools to act on both risky alcohol consumption in individual patients and the sources of alcohol in the community which cause the harm they experience. Most importantly, the proposed public health interventions act as a tool for emergency departments to regularly raise awareness with the public and policymakers regarding the impact of alcohol on patients, clinicians and hospitals.
Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and w ....Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and witness memory accuracy. Crucially, crimes are frequently distressing; therefore the interaction between intoxication and stress urgently requires exploration. This project will significantly advance our understanding of key mechanisms behind drug effects on memory, and support fairer judicial outcomes for all. Read moreRead less
Understanding the role of trauma in alcohol and other drug-related problems. This project aims to investigate the relationship between trauma and alcohol and other drug (AOD)-related problems. Using a robust set of qualitative and ethnographic methods, the project expects to advance international knowledge on how experiences of trauma influence AOD consumption, and the diverse factors that shape variation in experience and outcomes for individuals. Expected outcomes include targeted recommendati ....Understanding the role of trauma in alcohol and other drug-related problems. This project aims to investigate the relationship between trauma and alcohol and other drug (AOD)-related problems. Using a robust set of qualitative and ethnographic methods, the project expects to advance international knowledge on how experiences of trauma influence AOD consumption, and the diverse factors that shape variation in experience and outcomes for individuals. Expected outcomes include targeted recommendations to improve AOD responses, policy and trauma-informed AOD care, and increased capacity of the Australian health workforce to respond to trauma and AOD-related problems. This should provide significant benefit by reducing the harms, and economic and social costs associated with AOD consumption.Read moreRead less
Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Learning to Drink:a socio-cultural history of the introduction of alcohol to Indigenous Australians and a critique of existing explanations. The wide distribution of alcohol-related problems among Indigenous people is undoubtedly related to the ongoing legacy of Australia's colonisation. This study examines forces and factors that have shaped distinctive present-day Indigenous alcohol-related behavioural patterns, by analysing the history of interactions between Aborigines and colonisers around ....Learning to Drink:a socio-cultural history of the introduction of alcohol to Indigenous Australians and a critique of existing explanations. The wide distribution of alcohol-related problems among Indigenous people is undoubtedly related to the ongoing legacy of Australia's colonisation. This study examines forces and factors that have shaped distinctive present-day Indigenous alcohol-related behavioural patterns, by analysing the history of interactions between Aborigines and colonisers around alcoholic beverages. In this endeavour, the historical and cultural continuities in the style of drinking are the focus, rather than the number of consumers. Current understandings of problem drinking, emphasising distress and biology, impede progress and will be challenged. In contrast, a social learning model is conducive to optimism about implementing new treatment approaches.Read moreRead less
Developing the capacity to model the impact of interventions that target high-risk drinking among young Australians. Alcohol use is a major contributing factor to social and health problems among young Australians. The project will inform the development of effective policy by providing multidisciplinary research evidence and the capacity to model how various interventions impact on the prevalence of alcohol-related problems.
Heparin-induced Thrombocytopenia And Thrombosis: Better Understanding Of Pathogenesis And Improving Diagnosis And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$653,137.00
Summary
Heparin, a widely used drug, can cause an adverse effect which results in a fall of the platelet count and the development of serious thrombosis. This drug complication is mediated by an immune mechanism. This proposal aims to provide a better understanding of the disease mechanism. It also aims to develop a new test that will improve the diagnosis, and to produce a novel drug that will effectively suppress the immune reaction and improve the treatment.
Griseofulvin, A Novel Host-directed Antimalarial Drug
Funder
National Health and Medical Research Council
Funding Amount
$461,551.00
Summary
This grant is for a Phase II clinical trial to test an FDA & TGA approved drug for a new use as an antimalarial drug. The parasite uses an enzyme from the human RBC to help it replicate & early trials show this drug appears to disrupt the life cycle of the parasite. This Phase II clinical trial will test the drug on human subjects, & if successful, the drug will be a new and novel way in which to treat and prevent malarial infections in humans.
Alcohol’s harm to others: patterns, costs, disparities and precipitants. This project aims to generate understanding of the magnitude, character, economic burden, disparities and precipitants of occurrence of alcohol’s harm to others across Australia, using a national survey, crime, community services and health data and qualitative interviews. The project outcome will be a robust current evidence base for our partners, government and Australian society to underpin advocacy, policy and planning, ....Alcohol’s harm to others: patterns, costs, disparities and precipitants. This project aims to generate understanding of the magnitude, character, economic burden, disparities and precipitants of occurrence of alcohol’s harm to others across Australia, using a national survey, crime, community services and health data and qualitative interviews. The project outcome will be a robust current evidence base for our partners, government and Australian society to underpin advocacy, policy and planning, aimed at reducing alcohol-related harm and suffering.Read moreRead less
Roles Of Impaired Apoptosis And Differentiation In Tumourigenesis And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$21,656,910.00
Summary
The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remark ....The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remarkable cell suicide process termed apoptosis. Unfortunately, however, occasionally a random accident to the genes in one of our cells prevents the machinery for apoptosis from being turned on. In that case, the cell will not die when it should and, by continually dividing, it may eventually give rise to a cancer. Since most cancer cells still retain most of the machinery for apoptosis, however, a drug that could switch on this natural cell death machinery would provide a promising new approach to cancer therapy. Identifying and developing such drugs is one major long-term goal of this program. The other focus of our program concerns stem cells. These are rare cells with the remarkable ability to generate an entire tissue. For example, one of our laboratories has identified stem cells that can generate all the cells in the breast. The almost unlimited regenerative capacity of stem cells has a built-in danger. If a stem cell acquires the ability to proliferate excessively, it can go on to form a tumour. Indeed, many cancer researchers now suspect that rare stem cells within a tumour cause its inexorable growth. If tumour growth is maintained by stem cells, it will be essential to develop new forms of therapy that target these rare cancer stem cells rather than merely the bulk of the tumour cells. This is another key long-term goal of our program.Read moreRead less