Applying Pharmacometrics To Develop Novel Treatment Strategies For Staphylococcus Aureus Infections In Children
Funder
National Health and Medical Research Council
Funding Amount
$368,562.00
Summary
My research will determine the best way to give antibiotics to treat Staphylococcus aureus, one of the most common causes of infection in children. This includes finding out if we can provide highly effective treatment with antibiotics given by mouth instead of through a drip, and with fewer doses each day, so we can treat kids at home instead of in hospital. I will also explore new ways to use common antibiotics to treat antibiotic-resistant infections.
Clinical Pharmacology Of Methadone During Induction Onto Maintenance Treatment.
Funder
National Health and Medical Research Council
Funding Amount
$422,310.00
Summary
Heroin addiction can be very successfully treated by substituting heroin with methadone. The transition of stopping heroin and starting methadone is risky and can be associated with death. This application seeks to explore the mechanisms of the increased risk during this transition period so that appropriate management strategies might be instituted.
Analysis Of Low Radiation Dose Outside Of The Treatment Field Received By Cancer Patients Undergoing Radiotherapy
Funder
National Health and Medical Research Council
Funding Amount
$332,384.00
Summary
Every medical intervention is associated with risk. The present proposal aims to quantify the dose from radiation that is delivered outside the actual target region in radiotherapy of breast cancer patients. This information can help the development of better irradiation techniques as well as inform patients and their carers about possible long term side effects. Finally, the research can be used to finetune radiobiological models by comparing clinical outcomes and accurately calculated doses.
Optimal Duration Of Neoadjuvant Androgen Deprivation Therapy In Localised Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$275,000.00
Summary
Each year approximately 8000 men in Australia and New Zealand develop prostate cancer which has not spread widely and which is amenable to attempted cure by surgery or radiation. Prostate cancer depends for its growth on the male hormone, testosterone, which circulates in the blood. As a result treatment which reduces testosterone level ('androgen deprivation' [AD] therapy) can produce shrinkage of prostate cancer. In fact AD has caused temporary but valued relief to millions of men with cancer ....Each year approximately 8000 men in Australia and New Zealand develop prostate cancer which has not spread widely and which is amenable to attempted cure by surgery or radiation. Prostate cancer depends for its growth on the male hormone, testosterone, which circulates in the blood. As a result treatment which reduces testosterone level ('androgen deprivation' [AD] therapy) can produce shrinkage of prostate cancer. In fact AD has caused temporary but valued relief to millions of men with cancer of the prostate that has spread throughout the body for the last five decades, worldwide. It remains uncertain however whether AD administered before surgery or radiation will benefit any of the 8000 men each year who develop localised cancer by shrinking the cancer first. In 1996 a trial involving 800 men across Australia and New Zealand commenced under the auspices of the Trans-Tasman Radiation Oncology Group (TROG) to answer the questions: 1 - Does either 3 or 6 months AD prior to radiotherapy reduce the chances of recurrence of the cancer after radiotherapy? 2 - Does such therapy reduce the volume of tissue requiring radiotherapy and hence the chances of long term side effects after radiotherapy? This grant will support collection of follow-up information from the trial and hence answers to the questions asked.Read moreRead less
Optimizing Outpatient Parenteral Antibiotic Therapy To Support Hospital-in-the-home Program Across The Unique Environmental Conditions Of Australia
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
This project aims to solve problems associated with stability and dosing of antibiotic infusions given to patients in their homes, to support decision making by doctors and regulators. Currently, there is a lack of adequate data that complies with contemporary requirements. We will study infusion preparation both in laboratory settings and in ‘real-life’ conditions while being used by patients. We will enhance the stability of antibiotic preparations and optimize doses for effective treatment.