Deciphering The Role Of Atypical DNA Methylation In Neuronal Genome Regulation And Neurological Disorders
Funder
National Health and Medical Research Council
Funding Amount
$773,484.00
Summary
This research will use a combination of genomic, biochemical and functional genomics approaches to investigate the role of the atypical mCH form of DNA methylation in neuronal genome regulation and function, and provide new insights into the role of the epigenome in healthy brain function and neural pathologies.
Fighting slime with free radicals - new surface coatings for biofilm remediation. Bacterial biofilms are a major problem in a number of environmental, industrial and medical applications. They cause significant risks to human health and present an enormous economic burden to society. This project aims to develop smart polymeric coatings that will discourage bacterial attachment and ensure greater long term control over biofilm growth. These coatings represent a breakthrough in the field and will ....Fighting slime with free radicals - new surface coatings for biofilm remediation. Bacterial biofilms are a major problem in a number of environmental, industrial and medical applications. They cause significant risks to human health and present an enormous economic burden to society. This project aims to develop smart polymeric coatings that will discourage bacterial attachment and ensure greater long term control over biofilm growth. These coatings represent a breakthrough in the field and will have a profound impact in many areas, including reducing infections related to medical implants and improving the efficiency of marine engineering systems.Read moreRead less
EPIGENETIC REPROGRAMMING OF MALIGNANT BREAST CANCER
Funder
National Health and Medical Research Council
Funding Amount
$863,268.00
Summary
Poorly differentiated breast cancers are aggressive tumors, frequently resistant to chemotherapy and associated with high morbidity. Herein we propose the engineering of more selective therapeutic agents able to target the genes involved in cancer initiation and resistance to treatment. We aim to correct and reprogram the cancer cell genome in state that is similar to normal, not tumorigenic cells. This work will generate novel forms of treatment for cancers that are presently not curable.
Generation of peptidomimetic surfaces for biomaterials applications. Biomedical implants are increasingly being used for the treatment of a variety of ailments. This project will significantly contribute to the development of these bioengineered constructs, by introducing an innovative method for tailoring the nature of the surface of these materials with structures that mimic the response of biological surfaces. This technology has the potential to promote favourable interactions of cells with ....Generation of peptidomimetic surfaces for biomaterials applications. Biomedical implants are increasingly being used for the treatment of a variety of ailments. This project will significantly contribute to the development of these bioengineered constructs, by introducing an innovative method for tailoring the nature of the surface of these materials with structures that mimic the response of biological surfaces. This technology has the potential to promote favourable interactions of cells with biomedical implants, and an initial targeted application will be to use these bioengineered constructs in the treatment of preventable blindness and severe visual impairment, afflictions which affect over 180 million individuals worldwide.Read moreRead less
Environmentally sustainable asymmetric synthesis: design and development of chiral hydrogen bonding organocatalysts. There is a pressing need for more environmentally sustainable and economically viable methods for asymmetric synthesis. This project aims to design, synthesise and evaluate new organocatalysts based on the principle of hydrogen bonding activation, a common feature of Nature's catalysts, enzymes. These inexpensive, non-toxic, air- and moisture-stable catalysts may prove to be more ....Environmentally sustainable asymmetric synthesis: design and development of chiral hydrogen bonding organocatalysts. There is a pressing need for more environmentally sustainable and economically viable methods for asymmetric synthesis. This project aims to design, synthesise and evaluate new organocatalysts based on the principle of hydrogen bonding activation, a common feature of Nature's catalysts, enzymes. These inexpensive, non-toxic, air- and moisture-stable catalysts may prove to be more efficient, selective and have broader applicability than catalysts based on transition metals. The growing Australian pharmaceutical and biotechnology industries will benefit from the development of these new Advanced Materials and the training provided to young scientists in the sought-after fields of asymmetric synthesis and catalysis.Read moreRead less
Dendritic Organic Semiconductors. This Federation Fellowship, along with the creation of a Centre for Organic Semiconductor Research at The University of Queensland will enable Australian science to have a high profile in organic semiconductors. This is an important scientific and technological goal and the research programme will provide expertise for industry in Australia as well as potentially creating technologies for new industry. It will also provide a focus for other academic institutions ....Dendritic Organic Semiconductors. This Federation Fellowship, along with the creation of a Centre for Organic Semiconductor Research at The University of Queensland will enable Australian science to have a high profile in organic semiconductors. This is an important scientific and technological goal and the research programme will provide expertise for industry in Australia as well as potentially creating technologies for new industry. It will also provide a focus for other academic institutions in Australia by bringing together people with the requisite expertise in materials preparation, characterisation, modelling, photophysics, and device physics and engineering. Read moreRead less
Solution Processable, High Dimensional Dendrimers for Plastic Electronics. Microelectronics are present in our everyday life, from numerous chips in our vehicles to our mobile telephones; and the list is almost infinite. The electronics used today are limited to rigid surfaces, and are incompatible for the next generation of technology such as rollable displays and radio frequency identification cards. This proposal describes the development of a new class of high performance flexible electronic ....Solution Processable, High Dimensional Dendrimers for Plastic Electronics. Microelectronics are present in our everyday life, from numerous chips in our vehicles to our mobile telephones; and the list is almost infinite. The electronics used today are limited to rigid surfaces, and are incompatible for the next generation of technology such as rollable displays and radio frequency identification cards. This proposal describes the development of a new class of high performance flexible electronic inks that could be used in the next generation of microelectronics. There is a huge commercial interest in these electronic ink materials and this market is projected to be $7.7 billion by 2012. The proposed electronic inks address issues with current materials such as processability, performance and reproducibility.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0233459
Funder
Australian Research Council
Funding Amount
$136,000.00
Summary
High Pressure Chemistry Facility. High pressure is a mild, clean and high yielding method of promoting a variety of important chemical reactions. This proposal seeks equipment to conduct such reactions on a pilot and large scale or in large numbers (high-pressure combinatorial chemistry). This equipment would be unique in the Southern Hemsiphere and, together with existing infrastructure, creates an Australian centre in high pressure, liquid - phase chemistry. It would support research programm ....High Pressure Chemistry Facility. High pressure is a mild, clean and high yielding method of promoting a variety of important chemical reactions. This proposal seeks equipment to conduct such reactions on a pilot and large scale or in large numbers (high-pressure combinatorial chemistry). This equipment would be unique in the Southern Hemsiphere and, together with existing infrastructure, creates an Australian centre in high pressure, liquid - phase chemistry. It would support research programmes aimed at developing new materials for microelectronic components and new compounds for high through-put drug discovery and insecticide discovery programmes.Read moreRead less