Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect ....Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect their activity, and how they affect cellular function, tissue morphology and particle transport in a biological milieu. The project is expected to benefit the advanced manufacturing, veterinary and medical sectors and could lead to new chemotherapeutics.Read moreRead less
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revol ....ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revolutionizing diagnosis and therapy in many diseases. The CoE will be the focus of bio-nano research activity in Australia, uniting universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an enhanced understanding of the bio-nano-interface.Read moreRead less
Multifunctional and Multimodal Theranostics: Manipulating Material Properties for Advanced Diagnostics. The utilisation of polymers in nanomedicine requires a bottom-up approach, where the fundamental chemistry is well-established and understood before it enables an application. This project develops branched polymers as new nanomaterials for theranostics; imaging modalities that “switch-on” when miRNA is released will quantify how much nanomaterial gets to a specific site, while a built-in sens ....Multifunctional and Multimodal Theranostics: Manipulating Material Properties for Advanced Diagnostics. The utilisation of polymers in nanomedicine requires a bottom-up approach, where the fundamental chemistry is well-established and understood before it enables an application. This project develops branched polymers as new nanomaterials for theranostics; imaging modalities that “switch-on” when miRNA is released will quantify how much nanomaterial gets to a specific site, while a built-in sensor based on physical changes in the nanomaterial will measure the onset and progression of necrosis. The aim is to develop a fundamental understanding of how polymer architecture and functionality can be utilised to drive device performance, providing a platform to probe new technology and methodologies for development of next generation theranostics.Read moreRead less
On-demand 3D polymer scaffolds for directed stem cell differentiation. The project will develop new polymer gels that can be sculpted into shapes, representing tissues and organs. This 3D scaffold will provide a surface with biological signals to create functional tissues from stem cells. The approach will create engineered intestinal tissue with great promise to increase the survival rates of colon cancer patients.
Biomimetic hydrogels. Hydrogels are promising materials to repair and regenerate damaged tissues, but their weak mechanical properties limit their applications. This project aims to develop hydrogels with better mechanical properties by mimicking the way natural tissues, such as cartilage, work. Specifically, we aim to develop a new class of hydrogels by adding molecular polymer brushes to traditional materials. We will design the hydrogels with long-term stability and render them suitable as vi ....Biomimetic hydrogels. Hydrogels are promising materials to repair and regenerate damaged tissues, but their weak mechanical properties limit their applications. This project aims to develop hydrogels with better mechanical properties by mimicking the way natural tissues, such as cartilage, work. Specifically, we aim to develop a new class of hydrogels by adding molecular polymer brushes to traditional materials. We will design the hydrogels with long-term stability and render them suitable as viable hosts for chondrocytes. Through this project, we will grow fundamental knowledge in polymer chemistry and tissue engineering, and pave the way for new technologies to repair damaged joints and tissues.Read moreRead less
Design of novel nanoporous semiconductor materials for clean environment and energy. This project will develop a low cost nanoporous semiconductor device for the capture and conversion of CO2 into fuels by using water and sunlight. This novel approach will deliver a low cost technology that offers clean energy and will help to mitigate global warming.
Discovery Early Career Researcher Award - Grant ID: DE120101890
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Purification of contaminated wastewaters by modified Bayer layered double hydroxides. This project intends to develop enhanced adsorbent materials, prepared from industrial wastewater and seawater, for the decontamination of environments affected by Australian industries. This inexpensive novel material will be applicable to a wide range of purification applications and will reduce the environmental impact of Australian industries.
On-demand visible light degradable dental materials. This project aims to break new ground in the field of advanced adhesives by pioneering a unique system that can be cleaved with a defined visible light trigger, enabling the removal of previously bonded material without mechanical force. This would allow two materials to be strongly bonded, including dental crowns, braces and implants. The project will advance on-demand degradable materials design, introducing an advanced class of responsive n ....On-demand visible light degradable dental materials. This project aims to break new ground in the field of advanced adhesives by pioneering a unique system that can be cleaved with a defined visible light trigger, enabling the removal of previously bonded material without mechanical force. This would allow two materials to be strongly bonded, including dental crowns, braces and implants. The project will advance on-demand degradable materials design, introducing an advanced class of responsive networks for applications where reversible bonding is critical. It will have flow on benefits in future dental material applications and also have applications where simple-to-remove, temporary adhesives are required.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL170100014
Funder
Australian Research Council
Funding Amount
$3,275,680.00
Summary
Light-Induced chemical modularity: a new frontier in macromolecular design. This project aims to develop powerful light-driven chemistries for the modular construction of advanced macromolecular materials. The expected outcome is a versatile, light-based precision macromolecular synthetic technology platform, enabling critical advances in soft matter material design and synthesis, ranging from selectivity control of chemical reactions and information-coded and biomimetic light-responsive macromo ....Light-Induced chemical modularity: a new frontier in macromolecular design. This project aims to develop powerful light-driven chemistries for the modular construction of advanced macromolecular materials. The expected outcome is a versatile, light-based precision macromolecular synthetic technology platform, enabling critical advances in soft matter material design and synthesis, ranging from selectivity control of chemical reactions and information-coded and biomimetic light-responsive macromolecules to advanced functional photoresists for 3D laser lithography as well as materials that self-report structural transformations by light or are reprogrammable in their properties by photonic fields. Harnessing the power of light as a precision tool for the construction of advanced macromolecular materials will provide technology outcomes for Australian manufacturing industries from electronics to health. This includes laser-driven 3D printing technology at the nano-level, light-adaptive smart reprogrammable coatings and materials, synthetic proteins responsive to light as well as tailor-made single cell niches.Read moreRead less