Functional Nano-cement Scaffolds For The Treatment Of Osteoporotic Bone Defects
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Osteoporosis affects 1.2 million Australians and will cost $33.6 billion by 2022. This study aims to develop a novel nano-cement platform for custom-designed bone repair in osteoporosis, by using purpose-designed nanomaterials and advanced 3D printing technique. The research findings will lead to the development of a new bone repair strategy, expand knowledge on both biomaterials engineering and osteoporosis treatment, and improve the quality of life of Australians.
Generation of peptidomimetic surfaces for biomaterials applications. Biomedical implants are increasingly being used for the treatment of a variety of ailments. This project will significantly contribute to the development of these bioengineered constructs, by introducing an innovative method for tailoring the nature of the surface of these materials with structures that mimic the response of biological surfaces. This technology has the potential to promote favourable interactions of cells with ....Generation of peptidomimetic surfaces for biomaterials applications. Biomedical implants are increasingly being used for the treatment of a variety of ailments. This project will significantly contribute to the development of these bioengineered constructs, by introducing an innovative method for tailoring the nature of the surface of these materials with structures that mimic the response of biological surfaces. This technology has the potential to promote favourable interactions of cells with biomedical implants, and an initial targeted application will be to use these bioengineered constructs in the treatment of preventable blindness and severe visual impairment, afflictions which affect over 180 million individuals worldwide.Read moreRead less
Multivalent drug delivery carrier for the targeted delivery of platinum anticancer agents to hepatocytes. Hepatocellular carcinoma (HCC) is often treated with chemotherapy using cytotoxic drugs. This systemic treatment results in the distribution of the drug throughout the body. Employing a polymer particle as a drug carrier for these drugs ensures a temporal control of the release and therefore supply of the drug within the body. By attaching carbohydrate moieties onto the surface of the polyme ....Multivalent drug delivery carrier for the targeted delivery of platinum anticancer agents to hepatocytes. Hepatocellular carcinoma (HCC) is often treated with chemotherapy using cytotoxic drugs. This systemic treatment results in the distribution of the drug throughout the body. Employing a polymer particle as a drug carrier for these drugs ensures a temporal control of the release and therefore supply of the drug within the body. By attaching carbohydrate moieties onto the surface of the polymer particle the drug carrier can specifically be recognized by cell receptors, thus allowing a targeted delivery of the drug to the desired area in the body. A range of carbohydrate-based drug carriers will be synthesized and tested towards their interaction with hepatocytes to allow optimisation of this drug carrier system.
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Switching the light on cartilage repair. Osteoarthritis is a leading cause of pain and disability in adults and affects 15 per cent of the Australian population. This project will develop a revolutionary new approach to treat joint disorders using smart materials and stem cells. The novel materials and techniques developed will help Australia maintain its leading edge in biotechnology.
Broad spectrum nanomedicine for Meningitis treatment. Brain inflammatory diseases are among the top ten infectious causes of death. The project aims to provide Australian doctors with a superior alternative of treating infections that do not respond to conventional antibiotics. The nanomedicine developed will reduce the burden of hospital and boost Australia economy in the biomedical sector.
Core-shell nanoparticle from polymers with pendant cyclodextrins. A better drug delivery system will be developed for the treatment of cancer with albendazole. These nanoparticles enhance the circulation time in the body, but also facilitate the delivery of the drug to the site of the tumour, which will increase the efficacy of the treatment. The nanoparticles are obtained by processing polymers with pendant cyclodextrin groups, which are a type of complex sugars. Aim of this work is the explora ....Core-shell nanoparticle from polymers with pendant cyclodextrins. A better drug delivery system will be developed for the treatment of cancer with albendazole. These nanoparticles enhance the circulation time in the body, but also facilitate the delivery of the drug to the site of the tumour, which will increase the efficacy of the treatment. The nanoparticles are obtained by processing polymers with pendant cyclodextrin groups, which are a type of complex sugars. Aim of this work is the exploration of synthetic routes to generate nanoparticles. Tailoring the underpinning polymer structure of these nanoparticles will allow the optimisation of the release of albendazole from the drug carrier, thus improving cancer treatment.Read moreRead less
Degradable hollow microspheres for liver cancer treatment. The expected outcome of this multidisciplinary approach is a controlled drug delivery system for the treatment of liver cancer. We aim to increase the understanding of drug release using polymeric microspheres and the influence of the polymer properties on the release kinetics resulting in the tailored drug release for liver cancer treatment. An indepth knowledge in drug delivery can lead to optimised release kinetics leding to an increa ....Degradable hollow microspheres for liver cancer treatment. The expected outcome of this multidisciplinary approach is a controlled drug delivery system for the treatment of liver cancer. We aim to increase the understanding of drug release using polymeric microspheres and the influence of the polymer properties on the release kinetics resulting in the tailored drug release for liver cancer treatment. An indepth knowledge in drug delivery can lead to optimised release kinetics leding to an increased patient convenience and life prolonging treatments.Read moreRead less
Platinum drugs containing core-shell nanoparticles. Many drugs such as cancer drugs contain metal ions. While the therapeutic benefits of metal containing drugs are highly promising, their administration is often accompanied by substantial side effects. Encapsulation of these drugs into nano-sized core-shell particles will prolong the circulation of the drug and therefore reduce the amount of repeated administrations. In addition, the shape and nature of the particle will enable the targeted del ....Platinum drugs containing core-shell nanoparticles. Many drugs such as cancer drugs contain metal ions. While the therapeutic benefits of metal containing drugs are highly promising, their administration is often accompanied by substantial side effects. Encapsulation of these drugs into nano-sized core-shell particles will prolong the circulation of the drug and therefore reduce the amount of repeated administrations. In addition, the shape and nature of the particle will enable the targeted delivery of these drug loaded nanocarriers to the tumor while healthy tissue remains unaffected. Read moreRead less
Advanced micro-architecture and nanotopography for enhanced tissue growth in scaffolds. Tissue engineering scaffolds offer an urgently needed synthetic biomaterials solution to overcome disease transmission from donor transplants. This work will combine biomaterial chemistry and designed surface topography to trigger bone formation within a scaffold for the first time in the world. Collaboration with national research leaders on stem cell and animal testing of the new scaffolds will provide the ....Advanced micro-architecture and nanotopography for enhanced tissue growth in scaffolds. Tissue engineering scaffolds offer an urgently needed synthetic biomaterials solution to overcome disease transmission from donor transplants. This work will combine biomaterial chemistry and designed surface topography to trigger bone formation within a scaffold for the first time in the world. Collaboration with national research leaders on stem cell and animal testing of the new scaffolds will provide the necessary interdisciplinary approach to generate a new product for patients in need of bone regeneration. Australia will benefit from the contribution to medical science, the development of a new device for rapid prototyping tissue engineering scaffolds, retain biomaterials research expertise, and generate new biomedical products.Read moreRead less
New clean and green aqueous metathesis. The technique of olefin metathesis has already yielded new pharmaceuticals and materials for use in consumer products and ballistic protection. This project will help move metathesis into the realms of natures aqueous environment, a key advance if metathesis is to reveal its full potential in biological, polymeric, and pharmaceutical applications. We specifically aim to target treatments for cataract (and other conditions associated with an aging populatio ....New clean and green aqueous metathesis. The technique of olefin metathesis has already yielded new pharmaceuticals and materials for use in consumer products and ballistic protection. This project will help move metathesis into the realms of natures aqueous environment, a key advance if metathesis is to reveal its full potential in biological, polymeric, and pharmaceutical applications. We specifically aim to target treatments for cataract (and other conditions associated with an aging population) and also important new biopolymers for use in health technologies of the future.Read moreRead less