I am a molecular biologist investigating the role of SRY-SOX transcription factors in the formation and function of the gonad, and to a lesser extent, of bone, the brain and the pancreas. I also identify and functionally characterise other factors causing
“I am a biomedical scientist undertaking basic and clinical research on the pathophysiology of growth plate injury and repair, which critically impacts on children’s bone growth and growth disorders. I aim to investigate the underlying mechanisms and deve
I am a stem cell biologist researching the properties and application of mesenchymal stem cells, with an aim to develop cellular based therapies for repairing mineralised tissues such as bone, cartilage, dentin, cementum and other connective-supportive ti
I am an epidemiologist using large scale cohort study methods to investigate potentially modifiable factors affecting common conditions, particularly those related to ageing.
The Integration Of High Level Clinical Medicine, Molecular Genics, And Cutting Edge Neuroimaging
Funder
National Health and Medical Research Council
Funding Amount
$4,000,000.00
Summary
I aim to cement my place as the leading clinical and translational researcher in epilepsy internationally. My research and that of my wider group is focused on the integration of high level clinical medicine, molecular genetics and cutting-edge neuroimaging, which is informed and enhanced by clinically relevant basic neuroscience. This integrative model is unique in the epilepsy field. The Fellowship will give me the opportunity to expand this model and optimally utilize the rapidly developing t ....I aim to cement my place as the leading clinical and translational researcher in epilepsy internationally. My research and that of my wider group is focused on the integration of high level clinical medicine, molecular genetics and cutting-edge neuroimaging, which is informed and enhanced by clinically relevant basic neuroscience. This integrative model is unique in the epilepsy field. The Fellowship will give me the opportunity to expand this model and optimally utilize the rapidly developing technologies in genetics and imaging which are the two most important and productive fields in clinical neuroscience. I am in a unique international position to do this because of the clinical cohorts that I have meticulously collected and characterized over the last two decades, working with the remarkable group of clinical and basic science investigators that form my personal research team, and the wider group that I head, supported by an NHMRC Program Grant. This Fellowship will provide for a major injection of additional core genetic expertise to take us up to the next level necessary to crack the challenging problem of the complex genetics of the epilepsies. I wish to increase the impact and reputation of my wider group as the International Centre for innovative and clinically relevant research in epilepsy. This will enhance the reputation of Australia as a place of excellence in health and medical research.Read moreRead less
I am a Neuroscientist-Neurologist investigating brain pathways and neurotransmitters controlling body temperature. My research is highly relevant to human physical and mental health.
We are studying stem cells and their utility for transplantation into several organ systems including blood, neural and liver. We are also determining the relevance of epigenetic changes in transplanted cells that may interfere with normal function and could be the basis for disease.
Assemble A Cross-disciplinary Team With Requisite Skill To Uncover New Molecular Pathways Regulating Haemopoiesis
Funder
National Health and Medical Research Council
Funding Amount
$2,448,475.00
Summary
The major preoccupation of biology in the last decade has been the sequencing of the genomes of humans and important animal, plant, bacterial and viral organisms. With the completion of these projects, focus has shifted to understanding the molecular networks that regulate the biochemical, cellular and physiological processes that maintain health and the changes to these networks that lead to the onset and progression of disease. Within this fluid research landscape, my principal career goal ove ....The major preoccupation of biology in the last decade has been the sequencing of the genomes of humans and important animal, plant, bacterial and viral organisms. With the completion of these projects, focus has shifted to understanding the molecular networks that regulate the biochemical, cellular and physiological processes that maintain health and the changes to these networks that lead to the onset and progression of disease. Within this fluid research landscape, my principal career goal over the next 5 years is to ensure that, during a period of generational change at WEHI, its iconic molecular haematology team continues to flourish. Realizing this goal will allow us to use knowledge of the molecular determinants of health and disease to improve clinical outcomes of poorly treated conditions and in doing so improve the lives of patients and the health of the Australian economy.Read moreRead less