Australian Laureate Fellowships - Grant ID: FL110100196
Funder
Australian Research Council
Funding Amount
$2,638,208.00
Summary
New dimensions in organic bionics. The advent of the next generation of medical bionic devices is critically dependent on advances in multifunctional organic materials that, like living systems, provide spatial and temporal control. These advances will provide a platform to revolutionise medical treatments such as nerve and muscle regeneration, with impact on neural prosthetics.
Australian Laureate Fellowships - Grant ID: FL140100027
Funder
Australian Research Council
Funding Amount
$2,898,150.00
Summary
Under the hood: single-molecule studies of multi-protein machines. Under the hood: single-molecule studies of multi-protein machines. Living cells are filled with complex protein machines that are responsible for the molecular processes supporting life. This project is aimed towards the development of physical tools that enable the study of these protein complexes at the level of single molecules. This project aims to study the protein machinery responsible for DNA replication, the process of du ....Under the hood: single-molecule studies of multi-protein machines. Under the hood: single-molecule studies of multi-protein machines. Living cells are filled with complex protein machines that are responsible for the molecular processes supporting life. This project is aimed towards the development of physical tools that enable the study of these protein complexes at the level of single molecules. This project aims to study the protein machinery responsible for DNA replication, the process of duplicating genomic information before cell division. By making real-time single-molecule movies of the replication process, this project aims to unravel the molecular mechanisms of this important process and provide the knowledge required to understand disease mechanisms and catalyse drug development.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL140100052
Funder
Australian Research Council
Funding Amount
$2,500,000.00
Summary
Macromolecular design for bio-imaging and targeted delivery. Macromolecular design for bio-imaging and targeted delivery. A thorough understanding of how nanoparticles interact with biological systems is imperative if advances are to be made in using nanotechnology for therapeutic applications. Fundamental aspects of nanoparticle transport, targeting and cell uptake will be investigated. This project aims to design novel nanoparticulate systems for the delivery of both an endogenous signalling ....Macromolecular design for bio-imaging and targeted delivery. Macromolecular design for bio-imaging and targeted delivery. A thorough understanding of how nanoparticles interact with biological systems is imperative if advances are to be made in using nanotechnology for therapeutic applications. Fundamental aspects of nanoparticle transport, targeting and cell uptake will be investigated. This project aims to design novel nanoparticulate systems for the delivery of both an endogenous signalling molecule and genes to cells. The project aims to inform future optimal design criteria for bespoke nanoparticle delivery systems.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL0992409
Funder
Australian Research Council
Funding Amount
$2,996,243.00
Summary
The neural bases of decision-making. This research focuses on the neural bases of decision making, a general capacity affected by normal ageing, disorders associated with neurodegeneration including dementia, major psychiatric conditions and drug addiction. Changes in the neural systems that result in the cognitive and emotional dissociation reflected in these disorders constitute the highest health, economic and social capital attrition burden to Australia of any disease group, a burden that is ....The neural bases of decision-making. This research focuses on the neural bases of decision making, a general capacity affected by normal ageing, disorders associated with neurodegeneration including dementia, major psychiatric conditions and drug addiction. Changes in the neural systems that result in the cognitive and emotional dissociation reflected in these disorders constitute the highest health, economic and social capital attrition burden to Australia of any disease group, a burden that is only predicted to increase as the population ages. Understanding these changes in neural systems and their specific behavioural effects is, therefore, of critical importance and will ultimately provide new targets for treatment and rehabilitation.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL140100053
Funder
Australian Research Council
Funding Amount
$2,629,658.00
Summary
Science and secularisation. Science and secularisation. This project will explore the growth of science in the West and how it relates to a decline in the influence of religion. Specifically, it will investigate whether science has been a major cause of secularisation, and whether the pattern of scientific advance and corresponding religious decline observed in most Western countries is a universal one. This project aims to address a major unresolved issue concerning the relations between reli ....Science and secularisation. Science and secularisation. This project will explore the growth of science in the West and how it relates to a decline in the influence of religion. Specifically, it will investigate whether science has been a major cause of secularisation, and whether the pattern of scientific advance and corresponding religious decline observed in most Western countries is a universal one. This project aims to address a major unresolved issue concerning the relations between religion, science and modernisation. It also aims to shed light on a crucial issue for global security, namely, whether modernisation leads inexorably to secular, liberal democratic states, or whether new forms of technologically advanced, yet intrinsically religious states are possible.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL110100003
Funder
Australian Research Council
Funding Amount
$1,814,346.00
Summary
New directions, new problems and new data types in statistical science. Statistically challenging problems today involve answering many more questions than we have data. Solving them will elucidate the causes of diseases such as cancer, and provide better security for the community. The project will develop new methods for tackling these challenging problems, taking statistical science in new directions.
Australian Laureate Fellowships - Grant ID: FL170100160
Funder
Australian Research Council
Funding Amount
$2,568,846.00
Summary
A philosophy of medicine for the 21st century. This project aims to develop a new theory of health and disease to accommodate developments in contemporary biology such as the ‘developmental origins of health and disease’, the role of the microbiome in physiology, and the fact that our bodies are sites of evolutionary conflict between multiple genomes, particularly in early life. Present science does not fit with common-sense ideas about the identity and the goals of living systems and the projec ....A philosophy of medicine for the 21st century. This project aims to develop a new theory of health and disease to accommodate developments in contemporary biology such as the ‘developmental origins of health and disease’, the role of the microbiome in physiology, and the fact that our bodies are sites of evolutionary conflict between multiple genomes, particularly in early life. Present science does not fit with common-sense ideas about the identity and the goals of living systems and the project expects to generate a close collaboration between philosophers and biomedical scientists so that new ideas about health and disease can be fed back into proof-of-principle projects for innovative new approaches to the study of health and disease. The project will conduct methodologically innovative research in the philosophy of medicine, working in close collaboration with biomedical scientists to confront the transformational discoveries about the nature of living systems that have been made in the first years of the current century and to actively shape new forms of enquiry into health that reflect those discoveries. It will make the discipline of philosophy an active participant in the creation of integrative biomedical research.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL170100014
Funder
Australian Research Council
Funding Amount
$3,275,680.00
Summary
Light-Induced chemical modularity: a new frontier in macromolecular design. This project aims to develop powerful light-driven chemistries for the modular construction of advanced macromolecular materials. The expected outcome is a versatile, light-based precision macromolecular synthetic technology platform, enabling critical advances in soft matter material design and synthesis, ranging from selectivity control of chemical reactions and information-coded and biomimetic light-responsive macromo ....Light-Induced chemical modularity: a new frontier in macromolecular design. This project aims to develop powerful light-driven chemistries for the modular construction of advanced macromolecular materials. The expected outcome is a versatile, light-based precision macromolecular synthetic technology platform, enabling critical advances in soft matter material design and synthesis, ranging from selectivity control of chemical reactions and information-coded and biomimetic light-responsive macromolecules to advanced functional photoresists for 3D laser lithography as well as materials that self-report structural transformations by light or are reprogrammable in their properties by photonic fields. Harnessing the power of light as a precision tool for the construction of advanced macromolecular materials will provide technology outcomes for Australian manufacturing industries from electronics to health. This includes laser-driven 3D printing technology at the nano-level, light-adaptive smart reprogrammable coatings and materials, synthetic proteins responsive to light as well as tailor-made single cell niches.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL120100019
Funder
Australian Research Council
Funding Amount
$2,879,582.00
Summary
Protonic materials for green chemical futures. By emulating the structures that nature has evolved this project will create novel materials that will be used to develop new sustainable chemical technologies. Working with local and international collaborators, outcomes will include new approaches to the conversion of carbon dioxide into valuable chemicals and for renewable energy generation and storage.
Australian Laureate Fellowships - Grant ID: FL120100155
Funder
Australian Research Council
Funding Amount
$2,796,420.00
Summary
Informal life politics in the remaking of Northeast Asia: from Cold War to post-Cold War. This project will create a new approach to our understanding of non-state politics and social change in Northeast Asia as that region completes its crucial transition to a post-Cold War order. It will advance scholarship in area studies and strengthen Australia's place as a world-leading centre for the study of Northeast Asia.