Mechanisms, Biomarkers And New Therapies For Abdominal Aortic Aneurysm
Funder
National Health and Medical Research Council
Funding Amount
$551,370.00
Summary
Approximately 5% of men and 1% of women aged over 60 years develop artery weakening. The management of artery weakening is currently focused on radiological imaging and surgery. In this fellowship work will be performed to better understand the mechanisms involved in artery weakening, assess new ways of monitoring disease progression and evaluate new medical therapies. It is envisaged that the work will identify a number of new management stratergies for this common condition.
NOVEL SOLUTIONS FOR ANTIMICROBIAL RESISTANT PATHOGENS
Funder
National Health and Medical Research Council
Funding Amount
$474,513.00
Summary
Antibiotic resistance and infections caused by superbugs are major public health concerns. My fellowship aims to develop new strategies to prevent and treat infections caused by resistant superbugs. I will use innovative approaches both in the laboratory and in the hospital setting, and foster research across multiple groups, to solve “real-life” clinical problems. The proposed work will improve the outcomes for the most vulnerable hospitalised patients.
Viral infections that mothers catch during pregnancy still cause much illness in babies either in the womb, or after birth. One of these infections called CMV causes more babies to be born with malformation in Australia than any other infection, and is second only to cerebral palsy as a cause of serious problems in babies. Our studies are examining CMV in mothers and babies, leading to better diagnostic tests, researching use of existing and new antiviral drugs to reduce infection in these mothe ....Viral infections that mothers catch during pregnancy still cause much illness in babies either in the womb, or after birth. One of these infections called CMV causes more babies to be born with malformation in Australia than any other infection, and is second only to cerebral palsy as a cause of serious problems in babies. Our studies are examining CMV in mothers and babies, leading to better diagnostic tests, researching use of existing and new antiviral drugs to reduce infection in these mothers and babies.Read moreRead less
Pathophysiology And Treatment Of Malaria And Other Tropical Infectious Diseases Prevalent In Our Region
Funder
National Health and Medical Research Council
Funding Amount
$560,284.00
Summary
Nick Anstey is internationally recognised for his discoveries in malaria and other tropical infectious diseases. He leads a major tropical infectious disease research program in Darwin and SouthEast Asia that attracts some of the brightest researchers and students from Australia and beyond to understand disease mechanisms and work on new ways to treat illness and prevent death. He uses results to change policy and practice not only in Australia but around the world.
Trials of numerous agents to slow the progression of Parkinsons disease have provided ambiguous or negative results despite having good preliminary evidence for their efficacy. The most likely reason is that many nerve cells are already destroyed by the time of diagnosis. Thus effective therapies may be most (and possible only) effective when administered in the presymptomatic stages of disease. This proposal is directed at developing method to detect early presymptomatic Parkinsons disease.
Advances in positron emission tomography now allow specific pathological features of many brain diseases such as Alzheimer's disease to be measured with a brain scan during life. This Fellowship will assist Professor Rowe and his team in their world leading work on new PET scanning techniques to improve diagnosis and assist the development of treatment for Alzheimer's and other degenerative diseases of the brain.
Developing Improved Management For Peripheral Artery Diseases
Funder
National Health and Medical Research Council
Funding Amount
$569,219.00
Summary
~1 million Australians have peripheral artery disease. The current application is for a Practitioner Fellowship to support my research aimed at improving care of artery disease. The aim of the work is to develop improved management approaches for patients with blocked and weakened arteries. This work is particularly important given the recognised management deficiencies for patients with artery disease and the relative little research being undertaken in this area.
Understanding Early Life Risk Factors For Inflammation In The Rising Predisposition For NCDs
Funder
National Health and Medical Research Council
Funding Amount
$568,892.00
Summary
In 2011 the UN General Assembly identified the rise in non-communicable diseases (NCDs) as a major global threat, and prioritized preventive strategies against diseases like obesity, diabetes, heart disease, allergy and asthma. Common risk factors for these inflammatory diseases begin early in life, the most logical time for prevention. Our international interdisciplinary network aims to improve health and prevent NCDs by early interventions that reduce inflammation over the life-course.
Better Care Of Heart And Lung Disease For Aboriginal And Torres Strait Islander People In Rural And Remote Australia
Funder
National Health and Medical Research Council
Funding Amount
$380,583.00
Summary
Lung and heart disease are major contributors to the Aboriginal Australian and Torres Strait Islander health gap. This is even more so in remote and regional Australia. This Fellowship will generate new knowledge regarding how best to prevent, diagnose and treat heart and lung disease in this setting. Based in Alice Springs, it will bring together researchers and health care providers across northern and Central Australia and link them with our leading national research institutes.
In spite of significant progress, inflammatory diseases remain poorly understood and difficult to treat and are of growing public health importance. This fellowship application is for translational research on improving treatment for inflammatory diseases, including rheumatoid arthritis. It will link the senior clinical appointments of Prof Ian Wicks in Rheumatology at the Royal Melbourne Hospital with his appointment as Head of the Inflammation Division at the Walter & Eliza Hall Institute of M ....In spite of significant progress, inflammatory diseases remain poorly understood and difficult to treat and are of growing public health importance. This fellowship application is for translational research on improving treatment for inflammatory diseases, including rheumatoid arthritis. It will link the senior clinical appointments of Prof Ian Wicks in Rheumatology at the Royal Melbourne Hospital with his appointment as Head of the Inflammation Division at the Walter & Eliza Hall Institute of Medical Research.Read moreRead less