Age-related Macular Degeneration: A Cause And A Cure
Funder
National Health and Medical Research Council
Funding Amount
$828,300.00
Summary
Age-related macular degeneration (AMD) is a leading cause of vision loss and there is urgent need for an intervention to slow disease progression. AMD is characterised by debris accumulation in the retina and I will investigate if loss of function in cells that should clear this debris is a critical step in the development of AMD. I will trial a novel laser intervention to slow progression of disease and use basic science techniques to investigate the mechanisms of action of the laser.
Long-term Surgical And Socioeconomic Outcomes Following Aortopulmonary Septal Defect Repair In Children
Funder
National Health and Medical Research Council
Funding Amount
$89,197.00
Summary
About 2% of heart defects are due to communication between the 2 main arteries exiting the heart (truncus arteriosus and aortopulmonary window). If untreated, up to 30% of children die in the first year of life. With surgery many patients are now surviving into adulthood. The long-term outcomes are unknown. This study will review all patients with this defect across Australian and New Zealand. Results from this study will allow us to best manage these patients in the short and long-term.
How Should Moderate Iron Overload In Haemochromatosis Be Managed?
Funder
National Health and Medical Research Council
Funding Amount
$113,237.00
Summary
My PhD studies hereditary haemochromatosis which causes iron accumulation in the body which can be treated by removing blood. Whilst those with very high iron levels require treatment, it is not clear if those with only moderately raised iron also need treatment. If this study shows there is no difference in outcomes between the groups treatment to normalise body iron versus those who do not normalise body iron, this will change current practice.
Burden Of Rheumatic Heart Disease (RHD) And Impact Of Prevention Strategies: Comprehensive Evidence To Drive The RHD Endgame
Funder
National Health and Medical Research Council
Funding Amount
$960,655.00
Summary
Rheumatic heart disease is chronic damage to the heart valves caused by repeated bouts of acute rheumatic fever. Both are preventable, yet rates among Indigenous Australians are of the highest recorded. We propose to undertake the first multi-jurisdictional study of these conditions to determine trends in occurrence and evaluate the impact of existing interventions in Australia. Findings will be used to inform the development of a roadmap to remove RHD as a public health problem in Australia.
Improving The Prevention, Treatment And Management Of Cardiovascular & Chronic Disease In The Community
Funder
National Health and Medical Research Council
Funding Amount
$774,540.00
Summary
The identification, prevention and management of cardiovascular and chronic disease risk factors and understanding impact on clinical outcomes is fundamental to improving health and well-being. The program of work encapsulated in this application utilises modern epidemiological research methods involving large scale clinical trials, registries and epidemiological modelling to advance our understanding and provide new directions for cardiovascular disease prevention and management.
Stroke outcomes directly relate to brain tissue rescue. We have contributed to changes in clinical practice through many clinical trials of new protocols and therapeutic strategies. Our program will focus on brain salvage in the pre-hospital setting and the acute hospital environment. We will use novel approaches to enhance brain recovery and design new implementation strategies to maximise the benefits of these therapeutic advances.
Improving The Identification, Management And Outcome Of People With Depression And Other Chronic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$476,728.00
Summary
My research is designed to reduce depression and help people with chronic disease have a better quality of life. I will work with Aboriginal and/or Torres Strait Islander communities to improve how depression is identified, prevented and treated. I will work with the general community who have major depression, depression that is difficult to treat and people with depression and chronic disease to improve their outcomes. I will also aim to improve the recovery of people who have had a stroke.
Precision Treatment For Multiple Sclerosis: Maximising The Effect Of Immunomodulatory Therapy
Funder
National Health and Medical Research Council
Funding Amount
$537,272.00
Summary
Response to therapy varies greatly among patients with multiple sclerosis (MS). The current lack of individualised MS therapy may lead to suboptimal MS management and accumulation of preventable disability. We will use MSBase, a large international MS cohort, to evaluate the effect of different treatment strategies and of highly effective and novel therapies. Identifying the patients who will benefit from these therapies, we will provide the key evidence for individualised MS management.
Improving The Measurement Of Non-fatal Injury Burden - Validating The Global Burden Of Disease (GBD) Project Through Synthesis And Analysis Of The Six Leading Injury Outcome Cohort Studies From Around The World
Funder
National Health and Medical Research Council
Funding Amount
$155,443.00
Summary
This project will use data from the six largest and most comprehensive cohort studies across five countries to evaluate methods for determining the disability associated with injury. The findings will direct how injury burden is measured for by the Global Burden of Disease (GBD) Study, and for individual country or region-specific studies. The research will have direct relevance to Australia by improving outcome measurement in ways that are critical for enhanced clinical, public health policy an ....This project will use data from the six largest and most comprehensive cohort studies across five countries to evaluate methods for determining the disability associated with injury. The findings will direct how injury burden is measured for by the Global Burden of Disease (GBD) Study, and for individual country or region-specific studies. The research will have direct relevance to Australia by improving outcome measurement in ways that are critical for enhanced clinical, public health policy and planning settings.Read moreRead less