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Insights Into The Biology Of The Carcinogenic Blood Fluke, Schistosoma Haematobium – A First Response To The Wake-up Call
Funder
National Health and Medical Research Council
Funding Amount
$307,946.00
Summary
Schistosoma haematobium is a seriously neglected parasite that infects > 100 million people. Chronic infection severely affects the urino-genital system and causes malignant bladder cancer. Advanced technologies will be used to explore, for the first time, the molecular biology of this parasite, design new strategies to fight this insidious pathogen and understand how it induces cancer.
The Pathway Linking Tau And APP In Neurodegeneration
Funder
National Health and Medical Research Council
Funding Amount
$312,085.00
Summary
Recently I co-discovered a novel relationship between the AlzheimerÍs amyloid precursor protein and tau, both of which play a role in regulating neuronal iron levels. I predict that multiple failures in iron-regulating systems could foster a toxic iron accumulation in brain, leading to the development of neurodegenerative diseases. I hope to gain a better understanding of their mechanism of action and propose that this pathway is a target for therapeutic intervention.
Mechanisms Of Cortical And Respiratory Degenerations In Amyotrophic Lateral Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$333,900.00
Summary
This study will be the first to chronicle how and when motor neurons (MNs) in the brain and spinal cord degenerate before, during and after ALS symptoms in 2 different mouse models. The MNs studied control breathing muscles and are a key disease progression and mortality indicator in patients. I expect drastic shape and electrical abnormalities, providing information useful to clinicians about how and when brain and spinal cord MNs degenerate, uncovering new therapeutic targets and time-points.
Controlling The Development And Function Of Hindbrain Commissures In Vertebrate Animals: The Role Of Robo3 Receptor
Funder
National Health and Medical Research Council
Funding Amount
$393,834.00
Summary
Commissural axons connect and coordinate activity between neurons of the left and right sides of the central nervous system. In the forebrain, formation of commissural axons is determined by guidance factors at the midline between the two hemispheres, and abnormalities in guidance can cause developmental malformations. The aims of this project are to elucidate function of the Robo/Slit family of molecules in regulating axon guidance of commissural neurons, particularly in the corpus callosum.
The Role Of IGF2 And MTOR In Placental Development In Normal And Pregnancy Perturbations
Funder
National Health and Medical Research Council
Funding Amount
$207,002.00
Summary
20% of Australian women develop a problem during pregnancy which can cause illness or death of mother or baby. These are linked with poor placental growth and function. This project will identify novel regulators of human and mouse placental development using state-of-the-art molecular and cellular techniques. This will provide a better understanding of placental development and potentially direct future diagnostic and therapeutic strategies for pregnancy complications
Investigation Of The Molecular Basis Of Frailty And Development Of Frailty Biomarkers In A Novel Mouse Ageing Model
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Frailty is a state of high vulnerability for adverse health outcomes, and the prevalence of frailty increases with increasing age. There is very little known about why frailty develops, and there is also no widely accepted, efficient method of determining if someone is frail. This project will test blood markers for frailty, that will allow for optimization of treatment for older frail people and use mouse models of frailty to learn more about why frailty develops.