The Role Of UPF3B And Nonsense Mediated MRNA Decay Surveillance In The Pathology Of Intellectual Disability.
Funder
National Health and Medical Research Council
Funding Amount
$789,954.00
Summary
Proper functioning of the nonsense mediated mRNA decay (NMD or 'mRNA police') is crucial for any cell to ensure normal development and function. When NMD is compromised the outcome is learning and memory problems, autism or schizophrenia. Under this project we study malfunctioning NMD using stem and neuronal cells derived from patients' skin cells. Some of the affected genes might be considered for therapeutic interventions. NMD is relevant to 1000s of human disorders and as such it is of fundam ....Proper functioning of the nonsense mediated mRNA decay (NMD or 'mRNA police') is crucial for any cell to ensure normal development and function. When NMD is compromised the outcome is learning and memory problems, autism or schizophrenia. Under this project we study malfunctioning NMD using stem and neuronal cells derived from patients' skin cells. Some of the affected genes might be considered for therapeutic interventions. NMD is relevant to 1000s of human disorders and as such it is of fundamental importance.Read moreRead less
Examining The Impact Of Language Reclamation On Social And Emotional Well Being Among The Barngarla
Funder
National Health and Medical Research Council
Funding Amount
$1,111,633.00
Summary
Indigenous Australians are at high risk of experiencing mental illness. For many, it is the loss of land, culture, and identity that are causes of ill health. The Barngarla people of South Australia seek to reclaim their language due to its potential reinvigorating cultural identity and wellbeing. This offers a unique opportunity to document the links between language reclamation and wellness in Aboriginal people for the first time.
A Randomised Trial Of Rapid Point-of-care Tests For Chlamydia And Gonorrhoea Infections In Remote Aboriginal Communities
Funder
National Health and Medical Research Council
Funding Amount
$788,624.00
Summary
This project will trial a new kind of test for chlamydia and gonorrhoea that can provide immediate results at the time of clinical consultation. The trial will take place in remote Aboriginal communities. These tests have the potential to reduce re-infection rates by ensuring that people with infection have timely treatment. Health services will undertake standard practice in one year, and supplement standard practice by rapid point-of-care testing in the other year in a randomly assigned order.