Geometric methods in mathematical physiology. This project will develop new geometric methods for the analysis of multiple-scales models of physiological rhythms and patterns, and will design diagnostic tools to identify key parameters that cause and control these signals. Thus, this project will deliver powerful mathematics for detecting and understanding fundamental issues of physiological systems.
The Sakai scheme-Askey table correspondence, analogues of isomonodromy and determinantal point processes. The Australian mathematical sciences enjoys two research groups with active interests on Painleve equations in applied mathematics which are able to address difficult problems. Such a problem is to give a formulation of Sakai's 2001 classification of the Painleve equations in a form most suitable for applications. For this links will be made with a seemingly distinct area of mathematics - t ....The Sakai scheme-Askey table correspondence, analogues of isomonodromy and determinantal point processes. The Australian mathematical sciences enjoys two research groups with active interests on Painleve equations in applied mathematics which are able to address difficult problems. Such a problem is to give a formulation of Sakai's 2001 classification of the Painleve equations in a form most suitable for applications. For this links will be made with a seemingly distinct area of mathematics - the Askey table from the theory of hypergeometric orthogonal polynomials. A number of tractable PhD projects are suggested by this proposal.Read moreRead less
New Directions in Non-linear Mathematical Asymptotics. Major challenges such as predicting epidemics or modelling cancer rely on our understanding of simple mathematical models with extremely complicated solutions. The first and only model in the literature to reproduce the three-phase cycle of immune response in HIV/AIDS was based on cellular automata. Its results are extremely sensitive to infinitesimally small changes in parameters. Yet, no technique exists to study such variation in cellular ....New Directions in Non-linear Mathematical Asymptotics. Major challenges such as predicting epidemics or modelling cancer rely on our understanding of simple mathematical models with extremely complicated solutions. The first and only model in the literature to reproduce the three-phase cycle of immune response in HIV/AIDS was based on cellular automata. Its results are extremely sensitive to infinitesimally small changes in parameters. Yet, no technique exists to study such variation in cellular automata. This research will provide new methods for prediction and analysis of such models. Read moreRead less
Variational methods in partial differential equations. Research in partial differential equations is a very active area of modern mathematics linking nonlinear functional analysis, calculus of variations and differential geometry to applied sciences. This project will enable Australia-based researchers to participate in the forefront of mathematical research with leading international mathematicians by establishing new collaborations, strengthening on-going collaborations and providing internat ....Variational methods in partial differential equations. Research in partial differential equations is a very active area of modern mathematics linking nonlinear functional analysis, calculus of variations and differential geometry to applied sciences. This project will enable Australia-based researchers to participate in the forefront of mathematical research with leading international mathematicians by establishing new collaborations, strengthening on-going collaborations and providing international research experience for early career researchers. As a result, this proposal will enhance Australia's distinguished reputation in analysis and further link the UQ group with a number of mathematical institutes in USA and China.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100741
Funder
Australian Research Council
Funding Amount
$389,564.00
Summary
Analysis of defect driven pattern formation in mathematical models. . Defects, or heterogeneities, are common in nature and technology and therefore in mathematical models. This project will underpin the effects a defect can have on the dynamics of a model, characterise the new patterns created by a heterogeneity and see how the dynamics can be controlled by manipulating the heterogeneity. Moreover, these new insights will be applied to a model for skin cancer, resulting in a more appropriate mo ....Analysis of defect driven pattern formation in mathematical models. . Defects, or heterogeneities, are common in nature and technology and therefore in mathematical models. This project will underpin the effects a defect can have on the dynamics of a model, characterise the new patterns created by a heterogeneity and see how the dynamics can be controlled by manipulating the heterogeneity. Moreover, these new insights will be applied to a model for skin cancer, resulting in a more appropriate model and a mathematically justifiable analysis of a very important scientific problem.Read moreRead less
Multi-scale modelling of cell migration in developmental biology. Interpretative and predictive tools are needed for the comprehensive understanding of directed cell migration in the medical sciences. Mathematical models and modelling methodologies developed in this project will make a significant contribution to the investigation of cell migration and the testing and generation of hypotheses. Such models are needed to understand observed cellular patterns. This project will contribute to knowle ....Multi-scale modelling of cell migration in developmental biology. Interpretative and predictive tools are needed for the comprehensive understanding of directed cell migration in the medical sciences. Mathematical models and modelling methodologies developed in this project will make a significant contribution to the investigation of cell migration and the testing and generation of hypotheses. Such models are needed to understand observed cellular patterns. This project will contribute to knowledge of normal and abnormal developmental processes, especially in embryonic growth. Understanding these processes should lead to prediction and treatment of congenital disorders and contribute to a healthy start to life.Read moreRead less
Statistical and mathematical modelling to improve health care outcomes in hospitals. The aim of this project is to develop new quantitative techniques based on mathematical and statistical modelling that improve the outcomes of health care in hospitals. Hospital outcomes for patients are sub-optimal due to adverse events such as hospital acquired infections and fully stretched facilities. Research from this project will lead to resource usage being optimised using operations research; the tra ....Statistical and mathematical modelling to improve health care outcomes in hospitals. The aim of this project is to develop new quantitative techniques based on mathematical and statistical modelling that improve the outcomes of health care in hospitals. Hospital outcomes for patients are sub-optimal due to adverse events such as hospital acquired infections and fully stretched facilities. Research from this project will lead to resource usage being optimised using operations research; the transmission of hospital acquired infections being better understood using mathematical models; and better monitoring of adverse events and analyses of studies using statistical tools. Opportunities will be provided for hospital staff to acquire knowledge of the significance of these outcomes .Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100147
Funder
Australian Research Council
Funding Amount
$381,294.00
Summary
Coherent structures in chaotic dynamical systems. Using transfer operators and state-of-the-art multiplicative ergodic theory as a springboard, this project aims to develop innovative mathematics for bridging gaps between dynamical systems theory and applications. Coherent structures, such as oceanic eddies and atmospheric vortices, are prevalent in real-world dynamical systems and play a crucial role in both weather and climate systems. These structures arise in externally forced systems, and t ....Coherent structures in chaotic dynamical systems. Using transfer operators and state-of-the-art multiplicative ergodic theory as a springboard, this project aims to develop innovative mathematics for bridging gaps between dynamical systems theory and applications. Coherent structures, such as oceanic eddies and atmospheric vortices, are prevalent in real-world dynamical systems and play a crucial role in both weather and climate systems. These structures arise in externally forced systems, and the existing theory concerning their location, number and stability to model errors is much less understood than in the non-forced counterpart. The intended outcomes include new algorithms for the automatic detection of coherent structures and results about their stability under perturbations which are relevant to roles in both weather and climate systems.Read moreRead less
New mathematics to quantify fluctuations and extremes in dynamical systems. Many problems in the natural world result from the cumulative effect of extreme events in complex dynamical systems. Dynamical models of ecological and physical processes have internal variables that can combine to produce large observable changes. Quantitative estimation of the variability of these chaotic models is difficult because of the time dependence of the dynamics and their “long memory” due to significant deter ....New mathematics to quantify fluctuations and extremes in dynamical systems. Many problems in the natural world result from the cumulative effect of extreme events in complex dynamical systems. Dynamical models of ecological and physical processes have internal variables that can combine to produce large observable changes. Quantitative estimation of the variability of these chaotic models is difficult because of the time dependence of the dynamics and their “long memory” due to significant deterministic components. This project aims to develop mathematics and numerics to accurately quantify and assess these complicated variations. The project expects to provide powerful tools to predict harmful outcomes in biogeophysical systems, and assist with the development of mitigation strategies.Read moreRead less
A geometric theory for travelling waves in advection-reaction-diffusion models. Cell migration patterns often develop distinct sharp interfaces between identifiably different cell populations within a tissue. This research will develop new geometric methods for the mathematical analysis of cell migration models, and will design diagnostic tools to identify key parameters that cause and control these patterns and interfaces.