The Impact Of Sleep Disturbance On Cardiometabolic Function
Funder
National Health and Medical Research Council
Funding Amount
$295,223.00
Summary
Excess cardiovascular death is common in rotating shiftwork and obstructive sleep apnoea (OSA) populations. Substantial evidence links sleep disturbance in both ‘states’ to these adverse outcomes. This research will quantify the cardiovascular risk that sleep disturbance poses in both populations, determine whether people with untreated OSA who engage in shiftwork have amplified risk and determine whether a novel diet of high protein during shiftwork reduces risk. The findings may provide strate ....Excess cardiovascular death is common in rotating shiftwork and obstructive sleep apnoea (OSA) populations. Substantial evidence links sleep disturbance in both ‘states’ to these adverse outcomes. This research will quantify the cardiovascular risk that sleep disturbance poses in both populations, determine whether people with untreated OSA who engage in shiftwork have amplified risk and determine whether a novel diet of high protein during shiftwork reduces risk. The findings may provide strategies that could improve health in shiftworkers.Read moreRead less
The prevalence of asthma in Australia is amongst the highest in the world yet no trials of primary prevention have been conducted which address the most common known causative agent (housedust mite allergens) and the most common known protective factor (dietary omega-3 fatty acids). Until the effectiveness of interventions which address these factors is certain, the value of the wide array of advice given to asthmatics by various health institutions will not be known. We are applying to continue ....The prevalence of asthma in Australia is amongst the highest in the world yet no trials of primary prevention have been conducted which address the most common known causative agent (housedust mite allergens) and the most common known protective factor (dietary omega-3 fatty acids). Until the effectiveness of interventions which address these factors is certain, the value of the wide array of advice given to asthmatics by various health institutions will not be known. We are applying to continue the Childhood Asthma Prevention Study (CAPS) which has been underway since mid-1997. CAPS is a randomised controlled trial in which 616 infants at high risk of developing asthma because of a family history have been enrolled. The interventions include allergen reduction and dietary supplementation with omega-3 fatty acids. The interventions are designed to have maximum effect but be simple to implement by parents. Several measures of compliance are being collected and regular contact is maintained though telephone calls and frequent home visits. Objective and subjective measurements of exposures, atopy, diet and asthmatic symptoms are being collected at 3 month intervals and at medical assessments when the children are 18 months, 3 and 5 years old. It is essential that we continue the study until all children are aged 5 and we will be able to test conclusively whether the interventions have had a positive effect. If so, CAPS will form the basis for a nationwide public health campaign which will have the potential to reduce the incidence of childhood asthma in Australia.Read moreRead less