Salt And Cardiovascular Disease: Does Acute Salt-Sensitivity Convey Greater Cardiovascular Risk?
Funder
National Health and Medical Research Council
Funding Amount
$597,578.00
Summary
Salt intake of Australian adults is 10X more than required. Further, salt intake in very young children is alarmingly high secondary to high consumption of salty snacks and processed food. High dietary salt intake has been associated with increased cardiovascular disease and death. We will examine the cardiovascular risks for adults and children on a high salt diet and examine whether switching to a low salt diet ameliorates the high blood pressure and heart disease caused by high salt diets
Identifying Why Some People Consume Excess Dietary Fat. A Twin Study
Funder
National Health and Medical Research Council
Funding Amount
$365,462.00
Summary
Obesity is a significant public health problem, yet some individuals are less susceptible to the development of obesity. High fat eating patterns are commonly associated with overweight/obesity. The taste system is the gatekeeper of digestion and the sense of taste responds to fat, and that the fat taste response is associated with obesity. Using twins as subjects to disentangle the influences of 'nature and nuture', in this project we will identify the mechanisms responsible for linking fat tas ....Obesity is a significant public health problem, yet some individuals are less susceptible to the development of obesity. High fat eating patterns are commonly associated with overweight/obesity. The taste system is the gatekeeper of digestion and the sense of taste responds to fat, and that the fat taste response is associated with obesity. Using twins as subjects to disentangle the influences of 'nature and nuture', in this project we will identify the mechanisms responsible for linking fat taste response to development of obesity.Read moreRead less
Physiological Function Of Nedd4-2 In Regulating The Epithelial Sodium Channel And Cystic Fibrosis Transmembrane Conductance Regulator
Funder
National Health and Medical Research Council
Funding Amount
$949,572.00
Summary
Optimal transport of sodium and chloride ions is essential for the maintenance of electrolyte balance, blood volume, blood pressure and lung function. We are studying the control of a key sodium channel (the epithelial sodium channel) and a key chloride channel (cystic fibrosis transmembrane conductance regulator) by an enzyme called Nedd4-2. This project will enable us to understand how Nedd4-2 regulates these two ion channels and to study the pathological consequences of the loss of Nedd4-2.
Should You Be Eating That? Food-derived Bacteria And Their Role In Treating Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,405,182.00
Summary
The clinical application of medicines based on the microbes that exist as part of microbiomes is now a reality. Despite these rapid advances understanding how the bacteria are transmitted and recolonise after disruption is essential. Our preliminary data suggests that the average Australian adult consumes over 10 million bacteria per day in their diet. This project seeks to understand these relationships and how they can be exploited to develop the next generations of microbiome based medicine.