Evaluation Of Functional Protein Molecules In Treating Obesity
Funder
National Health and Medical Research Council
Funding Amount
$349,407.00
Summary
This project aims to reduce excessive food consumption by controlling the satisfaction that people get from eating. This will be achieved through varying protein supplements (whey, leucine and beta-conglycinin) and their combinations. The idea is that people will feel satisfied despite eating less, leading to weight loss and the correction of related metabolic disorders.
High Protein, Low Glycemic Load Weight Loss Diets In Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$906,928.00
Summary
High protein, low glycemic load weight loss diets have the potential to be of value in long term weight control but there is little long term data available. There is also some uncertainty about the long term safety of high protein diets and this needs clarification in long term trials. As compliance to the diet is the major issue in long term trials we will explore new ways of getting people to stay in long term studies and maintain a calorie reduced diet.
Transforming Mealtime Insulin Dosing Using An Innovative New Bolusing Calculator To Optimise Glycaemic Control In Type 1 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
People with type 1 diabetes require life-long insulin injections to maintain their blood glucose levels in the optimal range. Mealtime dose estimations based solely on carbohydrate have limited efficacy as they fail to take fat and protein into account. The aim of this project is to develop an evidence-based insulin bolusing calculator integrated into a smartphone app to enhance blood glucose control and reduce the daily burden of disease and the risk of life-threatening complications.
The Impact Of Sleep Disturbance On Cardiometabolic Function
Funder
National Health and Medical Research Council
Funding Amount
$295,223.00
Summary
Excess cardiovascular death is common in rotating shiftwork and obstructive sleep apnoea (OSA) populations. Substantial evidence links sleep disturbance in both ‘states’ to these adverse outcomes. This research will quantify the cardiovascular risk that sleep disturbance poses in both populations, determine whether people with untreated OSA who engage in shiftwork have amplified risk and determine whether a novel diet of high protein during shiftwork reduces risk. The findings may provide strate ....Excess cardiovascular death is common in rotating shiftwork and obstructive sleep apnoea (OSA) populations. Substantial evidence links sleep disturbance in both ‘states’ to these adverse outcomes. This research will quantify the cardiovascular risk that sleep disturbance poses in both populations, determine whether people with untreated OSA who engage in shiftwork have amplified risk and determine whether a novel diet of high protein during shiftwork reduces risk. The findings may provide strategies that could improve health in shiftworkers.Read moreRead less
Diet And The Gut Microbiota As The Basis For Food Allergies
Funder
National Health and Medical Research Council
Funding Amount
$669,091.00
Summary
Diet and the composition of the gut microbiota represent new avenues to prevent or treat human diseases. We propose that allergies in western countries result from altered gut homeostasis. This application seeks to understand all the molecules involved, and to discover new bacteria that associate with, or protect from allergies.
Restricting Dietary Advanced Glycation End Product Intake As A Potential Therapeutic Tool In Diabetic Nephropathy.
Funder
National Health and Medical Research Council
Funding Amount
$483,351.00
Summary
Kidney disease is a serious complication of diabetes and may occur as a result of a biochemical process known as advanced glycation. These advanced glycation end products (AGEs) accumulate in the kidney causing disruption of function. Due to modern food processing techniques, the Australian diet has a high AGE content. Over-eating foods which are high in AGEs may worsen diabetic kidney disease. This proposal will test the effects of dietary AGE restriction and overfeeding on kidney function.
Identifying Why Some People Consume Excess Dietary Fat. A Twin Study
Funder
National Health and Medical Research Council
Funding Amount
$365,462.00
Summary
Obesity is a significant public health problem, yet some individuals are less susceptible to the development of obesity. High fat eating patterns are commonly associated with overweight/obesity. The taste system is the gatekeeper of digestion and the sense of taste responds to fat, and that the fat taste response is associated with obesity. Using twins as subjects to disentangle the influences of 'nature and nuture', in this project we will identify the mechanisms responsible for linking fat tas ....Obesity is a significant public health problem, yet some individuals are less susceptible to the development of obesity. High fat eating patterns are commonly associated with overweight/obesity. The taste system is the gatekeeper of digestion and the sense of taste responds to fat, and that the fat taste response is associated with obesity. Using twins as subjects to disentangle the influences of 'nature and nuture', in this project we will identify the mechanisms responsible for linking fat taste response to development of obesity.Read moreRead less
Dietary Protein-induced DNA Damage In Colon And Consequences For Colorectal Oncogenesis
Funder
National Health and Medical Research Council
Funding Amount
$604,797.00
Summary
This research will explore the effects of dietary protein on genetic damage to cells lining the large bowel and risk of developing colorectal cancer. We will determine the degree and type of DNA damage resulting from increased protein, the cellular response to this DNA damage, whether it increases risk for developing bowel cancer and whether it can be minimised by other foods in both an animal model and humans.
Molecular Mechanism And Novel Activators Of Amino Acid And Calcium-sensing Class 3 G-protein Coupled Receptors
Funder
National Health and Medical Research Council
Funding Amount
$519,715.00
Summary
When we eat protein-containing foods, our bodies extract twenty different amino acids for growth and tissue regeneration. Broad-spectrum amino acid sensing receptors detect the increases in blood amino acid levels and respond by triggering the release of biochemical signals. This project will establish the molecular rules by which these receptors work and identify novel activators with potential therapeutic application for the control of growth, tissue regeneration and calcium metabolism.
The Role Of Dietary Protein On Weight Loss And Body Composition In Men And Women With Insulin Resistance
Funder
National Health and Medical Research Council
Funding Amount
$208,055.00
Summary
Obesity is an increasing problem in the community and is associated with an increased incidence of high blood pressure, high cholesterol and triglycerides, diabetes, heart disease and cancer. Although conventional dietary advice for weight loss is a low fat high carbohydrate and high fibre diet there is a very strong interest in the media and the general population in alternative diets that feature reduced carbohydrate with the remainder of the diet either protein or a mixture of protein and fat ....Obesity is an increasing problem in the community and is associated with an increased incidence of high blood pressure, high cholesterol and triglycerides, diabetes, heart disease and cancer. Although conventional dietary advice for weight loss is a low fat high carbohydrate and high fibre diet there is a very strong interest in the media and the general population in alternative diets that feature reduced carbohydrate with the remainder of the diet either protein or a mixture of protein and fat. Unfortunately there is very little published data to guide the decisions of health professionals in this area and there is a strong demand for such information. We plan to perform 2 large weight loss studies which focus on high protein diets with one exchanging protein for carbohydrate and keeping fat constant and the second exchanging protein for fat keeping carbohydrate constant. We will assess whether the high protein diets blunt the decrease in metabolic rate that occurs with weight loss, and whether it spares some of the inevitable loss of muscle mass. We will also measure whether high protein diets improve glucose metabolism in people already at risk of diabetes and heart disease because of their obesity and high insulin levels.Read moreRead less