Dietary Patterns, Cognitive Performance And Cardiovascular Risk Factors In Australia, The United States And Luxembourg: An International Comparison And Dietary Intervention Trial
Funder
National Health and Medical Research Council
Funding Amount
$347,227.00
Summary
Ageing and the growing obesity epidemic are two contributing factors to cognitive decline. This research will identify dietary patterns that are associated with better cognitive function using data from individuals in Australia, the United States and Europe, and be used to guide dietary strategies to prevent or slow cognitive decline in at-risk individuals. Delaying or preventing the onset of dementia will save the Australian health care system billions of dollars.
Mediterranean Diet And Mortality: Analysis Of Longitudinal Dietary Patterns Using Newly Developed Statistical Methods
Funder
National Health and Medical Research Council
Funding Amount
$340,547.00
Summary
Assessment of the effect of changes in diet of health has not undergone rigourous analytical assessment in the scientific literature. This proposal focusses on patterns of change over time in a Mediterranean diet in 41,000 persons in the Melbourne Collaborative Cohort Study. It will assess the benefits of adoption and maintenance of this diet over an extended period, as well as determining how the benefits of the diet depend on a person's age at its adoption, and how the benefits of the diet int ....Assessment of the effect of changes in diet of health has not undergone rigourous analytical assessment in the scientific literature. This proposal focusses on patterns of change over time in a Mediterranean diet in 41,000 persons in the Melbourne Collaborative Cohort Study. It will assess the benefits of adoption and maintenance of this diet over an extended period, as well as determining how the benefits of the diet depend on a person's age at its adoption, and how the benefits of the diet interplay with other potential lifestyle changes.Read moreRead less
Metabolically Healthy Obesity: An Investigation Of Its Predictors And Outcomes Across The Lifecourse
Funder
National Health and Medical Research Council
Funding Amount
$337,031.00
Summary
Obesity is a major health problem with 30% of Australian adults being obese. Despite attention on the health impact of obesity and programs to reduce weight, maintaining weight loss is difficult. However, not all obese individuals are at higher risk of disease. This research will examine the behavioural and genetic factors of these individuals and their risk of disease. The findings may inform new treatments for obesity that focus less on weight loss and more on health.
School Versus Community-based Albendazole Deworming For Control Of Soil Transmitted Helminths In School-age Children In The Philippines – A Cluster Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,336,408.00
Summary
Intestinal parasites are a global health problem. The World Health Organization recommends regular distribution of deworming drugs, targeting school aged children. This is effective for the children receiving the drugs but does not have an impact in the wider community. We aim to determine the best strategy for delivery of deworming drugs, to achieve the maximum benefit both for children and wider community, by directly comparing the benefits of a school-targeted vs a community-mass approach.
Epidemiology Of Allergic Diseases And The Role Of Early Life Eczema
Funder
National Health and Medical Research Council
Funding Amount
$416,306.00
Summary
Eczema prevents our children from getting a healthy start to life, increases their risk of developing asthma and hay-fever, and we don’t know how to prevent this condition. Dr. Lowe will help identify causes and the outcomes of eczema and allergic diseases in early life, by using a number of important research projects. This research includes an intervention trial that aims to prevent the development of allergic disease and sensitisation, which Dr Lowe leads
A Randomised Controlled Trial Of Daily Antibacterial Mouthwash To Reduce Pharyngeal Gonorrhoea Among Men Who Have Sex With Men (MSM)
Funder
National Health and Medical Research Council
Funding Amount
$376,730.00
Summary
Gonorrhoea is a common sexually transmitted infection (STI) among gay men, and the throat is the commonest site of infection. There is early data to suggest Listerine mouthwash can be used to prevent gonorrhoea. Our study will examine whether men use Listerine every day will reduce the risk of gonorrhoea in the throat compared those who use another mouthwash product which does not have an effect on gonorrhoea.
HIV Pre-exposure Prophylaxis In Men Who Have Sex With Men: Investigating Impacts On HIV Incidence And Novel Methods Of Engagement
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
HIV infections are increasing in gay men and other men who have sex with men (MSM) in Australia and Indonesia. A promising new HIV prevention strategy is HIV pre-exposure prophylaxis (PrEP), which involves HIV-negative individuals taking one pill containing HIV treatments per day to prevent infection. PrEP is highly effective when taken correctly. Access to PrEP is currently very limited. Studies to investigate the best ways to implement PrEP services are required in Australia and Indonesia.
Reducing Unintended Pregnancies Among Female Sex Workers In Kenya Using MHealth: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$92,161.00
Summary
This research aims to reduce the high rates of unintended pregnancy experienced by female sex workers (FSW) in Kenya. It involves the development of a health promotion program delivered by mobile phone (mHealth intervention) to improve FSWs’ knowledge of SRH and reduce their risk of unintended pregnancy. The intervention will be trialled with 860 FSWs from 86 sex work venues in Mombasa. If effective, it can be implemented to improve women’s health in many and diverse settings.
New Technologies To Reduce The Population Burden Of Sexually Transmitted Infections
Funder
National Health and Medical Research Council
Funding Amount
$772,605.00
Summary
I propose a five year program of public health research on the evaluation of innovative technologies to prevent sexually transmitted infections (STIs) and their adverse consequences in populations at highest risk; Aboriginal and Torres Strait Islander people, youth, men who have sex with men and people in high STI-burden resource-limited countries. My research over the next five years will lead to substantial improvements in the health of people at greatest risk of STIs.
Does Vitamin D Supplementation Reduce Mortality For Older Adults?: A Pilot Trial
Funder
National Health and Medical Research Council
Funding Amount
$443,311.00
Summary
Studies suggest that people with low vitamin D may have increased risks of some chronic diseases and early death. This has prompted calls to introduce population-wide vitamin D supplementation, although there is no good evidence from clinical trials. In a landmark 2008 report, the International Agency for Research on Cancer called for randomised trials of high-dose vitamin D supplementation. We plan to pilot such a trial, to inform implementation of a large-scale chemoprevention trial.