It is clear that the rate of obesity is increasing dramatically. Better therapeutic strategies are required to treat this debilitating disease. In this study we will determine the effects of sugary drinks on the amount of food eaten and subsequent changes in weight gain. By understanding how sugary drinks affect rates of weight gain we will be able to formulate better strategies to combat obesity.
Nutritional And Genetic Factors Associated With Genome Damage In Children
Funder
National Health and Medical Research Council
Funding Amount
$715,131.00
Summary
This project will investigate the link between children's diet and damage to their DNA. Damage to DNA is known to accumulate throughout life, and to be associated with risk of cancer and other diseases in adulthood. If we can show that poor diet in childhood increases DNA damage in childhood, it suggests that poor diet early in life may also increase risk of cancer and other diseases in adulthood. This will underpin important, salient health promotion messages we can provide to parents.
Restricting Dietary Advanced Glycation End Product Intake As A Potential Therapeutic Tool In Diabetic Nephropathy.
Funder
National Health and Medical Research Council
Funding Amount
$483,351.00
Summary
Kidney disease is a serious complication of diabetes and may occur as a result of a biochemical process known as advanced glycation. These advanced glycation end products (AGEs) accumulate in the kidney causing disruption of function. Due to modern food processing techniques, the Australian diet has a high AGE content. Over-eating foods which are high in AGEs may worsen diabetic kidney disease. This proposal will test the effects of dietary AGE restriction and overfeeding on kidney function.
Exposure And Risks From Persistent Organic Pollutants Through Consumption Of Traditional Seafood
Funder
National Health and Medical Research Council
Funding Amount
$322,042.00
Summary
For many coastal Aboriginal and Torres Strait Islander people, local marine resources provide an important and integral aspect of the communities' diet, culture and traditions. The health benefits associated with seafood consumption have been well documented. On the other hand, many environmental contaminants accumulate in the marine environment. In particular persistent organic pollutants (POPs) have the potential to accumulate to elevated levels in the marine food chain, including humans. Cons ....For many coastal Aboriginal and Torres Strait Islander people, local marine resources provide an important and integral aspect of the communities' diet, culture and traditions. The health benefits associated with seafood consumption have been well documented. On the other hand, many environmental contaminants accumulate in the marine environment. In particular persistent organic pollutants (POPs) have the potential to accumulate to elevated levels in the marine food chain, including humans. Consumption of food contaminated with POPs can pose a risk of causing adverse health effects, including cancer, endocrine disruption, developmental and immunotoxic responses. Recent studies in Queensland have shown elevated concentrations of POPs, specifically dioxins, in the near shore marine environment. Concentrations present in dugong and turtle tissues were found to be among the highest reported compared to other marine biota worldwide. These species represent an integral part of the traditions and diet for many coastal Aboriginal and Torres Strait Islander communities. However, to date no information on exposure to these compounds from locally sourced seafood exists in Australia. The proposed study will redress this lack of information and provide an understanding of the risks associated with the consumption of traditional seafood from local contaminated areas. In collaboration with the Quandamooka community, Moreton Bay in South East Queensland this will provide a case study with the objectives of: 1. Assessing the qualitative and quantitative risks associated with consumption of traditional and contemporary seafood sourced from local contaminated areas. 2. Providing communities with a thorough understanding of food contamination and building internationally competitive capacity in Australian Indigenous researchers. 3. Develop risk management options that allow informed decisions making on POP exposure and are acceptable to the community.Read moreRead less
Effects Of Dietary Protein On Gastrointestinal Function: Implications For The Regulation Of Energy Intake In Obesity
Funder
National Health and Medical Research Council
Funding Amount
$677,157.00
Summary
Obesity is largely due to energy intake exceeding energy expenditure. The CI has reported that dietary protein markedly reduces energy intake but the mechanisms underlying this effect remain unknown. The proposed studies will determine whether gastrointestinal mechanisms are involved in the regulation of appetite and energy intake and how they relate to body weight reduction in obese subjects. The research represents a unique approach to the management of obesity and health.
Interactions Of Gastric Hormones With Vagal Afferent Pathways And The Role Of This System In Obesity
Funder
National Health and Medical Research Council
Funding Amount
$550,918.00
Summary
When we feel full after a meal it is the result of a variety of different nerve signals from the gut in response to distension of the stomach and specific nutrients. These signals are disordered in obesity and this project aims to find out how to correct this problem in this modern day epidemic.
The Role Of Dietary Protein On Weight Loss And Body Composition In Men And Women With Insulin Resistance
Funder
National Health and Medical Research Council
Funding Amount
$208,055.00
Summary
Obesity is an increasing problem in the community and is associated with an increased incidence of high blood pressure, high cholesterol and triglycerides, diabetes, heart disease and cancer. Although conventional dietary advice for weight loss is a low fat high carbohydrate and high fibre diet there is a very strong interest in the media and the general population in alternative diets that feature reduced carbohydrate with the remainder of the diet either protein or a mixture of protein and fat ....Obesity is an increasing problem in the community and is associated with an increased incidence of high blood pressure, high cholesterol and triglycerides, diabetes, heart disease and cancer. Although conventional dietary advice for weight loss is a low fat high carbohydrate and high fibre diet there is a very strong interest in the media and the general population in alternative diets that feature reduced carbohydrate with the remainder of the diet either protein or a mixture of protein and fat. Unfortunately there is very little published data to guide the decisions of health professionals in this area and there is a strong demand for such information. We plan to perform 2 large weight loss studies which focus on high protein diets with one exchanging protein for carbohydrate and keeping fat constant and the second exchanging protein for fat keeping carbohydrate constant. We will assess whether the high protein diets blunt the decrease in metabolic rate that occurs with weight loss, and whether it spares some of the inevitable loss of muscle mass. We will also measure whether high protein diets improve glucose metabolism in people already at risk of diabetes and heart disease because of their obesity and high insulin levels.Read moreRead less
Gastrointestinal Function And Appetite In Obesity - Acute And Longer-term Effects Of Changes In Energy Intake
Funder
National Health and Medical Research Council
Funding Amount
$744,645.00
Summary
The prevalence of obesity is assuming epidemic proportions. While weight loss diets help people to lose weight, body weight stabilises over time despite continued dieting. Our research proposal represents a novel initiative with the aim to understand the adaptations in gastrointestinal mechanisms in response to acute and longer-term dietary restriction that compromise weight loss. Ultimately our research will help to develop weight loss strategies that are successful in the long-term.